| Project/Area Number |
25515010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
睡眠科学
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| Research Institution | Neuropsychiatric Research Institute |
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Principal Investigator |
TSUIKI Satoru 公益財団法人神経研究所, 研究部, 研究員 (90376765)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Tatsuya 公益財団法人神経研究所, 研究部, 研究員 (90624833)
KOBAYASHI Mina 公益財団法人神経研究所, 研究部, 研究員 (40596037)
NAKAYAMA Hideaki 東京医科大学, 医学部, 准教授 (30444144)
INOUE Yuichi 公益財団法人神経研究所, 研究部, 研究員 (50213179)
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| Research Collaborator |
ISONO Shiroh
TAKEI Yoichiro
ENO Yukiko
EBATO Arisa
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 睡眠時無呼吸症候群 / 上気道 / 閉塞性睡眠時無呼吸症候群 / collapsible tube / コラプシブルチューブ / 睡眠時無呼吸 / 上気道閉塞 / 社会系歯学 / 睡眠学 |
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| Outline of Final Research Achievements |
In individuals with obstructive sleep apnea (OSA), a neuromuscular compensation mechanism is augmented in defense of upper airway patency. We investigated the volume-pressure relationship of the isolated upper airway in 7 OSA patients. The volume-pressure properties were evaluated in terms of elastance of the upper airway (Euaw). A significant correlation was observed between Euaw and the Apnea Hypopnea Index. Accordingly, the upper airway is less collapsible in the more severe OSA patients probably due to the more increased upper airway muscle activity.
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