Statistical Models for Fractionated Irradiation

• Project/Area Number: 25540008
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Statistical science
• Research Institution: Hokkaido University
• Principal Investigator: Mizuta Masahiro 北海道大学, 情報基盤センター, 教授 (70174026)
• Co-Investigator(Kenkyū-buntansha): DATE Hiroyuki 北海道大学, 大学院保健科学院, 教授 (10197600)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 線量効果に関する数理モデル / 悪性腫瘍 / 危険臓器 / 制約条件付最適化 / 分割照射 / 条件付最適化問題 / 腫瘍 / 生存モデル / DVH

Outline of Final Research Achievements

Radiotherapy of solid tumors has been performed with various fractionation regimens. However, mathematical model for the fractionation regimens remains insufficient. We forces on (modified) linear-quadratic models and construct a framework for evaluation of fractionation regimens based on the models.
It was found that the optimization of fractionation scheme incorporating the dose volume histogram is possible by employing appropriate cell surviving models. It is possible to optimize the number of fractions and dose per fraction based on the physical dose distribution considering the effects on tumor and organ at risks (OARs) around the tumor. This method may stipulate a new guideline to optimize the fractionation regimen for physics-guided fractionation.

Research Products

• [Journal Article] Detection of differential distributions of methylation patterns (2016)
  • Author(s): Matsui Y, Mizuta M, Miyano S, Shimamura T
  • Journal Title: Bioinformatics Volume: 印刷中 Issue: 15 Pages: 1-8
  • DOI: 10.1093/bioinformatics/btw138
  • Peer Reviewed / Open Access
• [Journal Article] Exploratory Methods for Joint Distribution Valued Data and their Application (2015)
  • Author(s): Kazuto Igarashi, Hiroyuki Minami, Masahiro Mizuta
  • Journal Title: Communications for Statistical Applications and Methods Volume: 22-3 Issue: 3 Pages: 265-276
  • DOI: 10.5351/csam.2015.22.3.265
  • Peer Reviewed / Open Access
• [Journal Article] Future of Stereotactic Irradiation - Dose Composition Radiotherapy (DCRT) (2015)
  • Author(s): Hiroki Shirato, Rikiya Onimaru, Shinichi Shimizu, Naoki Miyamoto, Ruijiang Li, Albert C. Koong, Masahiro Mizuta
  • Journal Title: Stereotactic Body Radiation Therapy: Principles and Practices, Springer Volume: 1 Pages: 239-250
  • DOI: 10.1007/978-4-431-54883-6_19
  • ISBN: 9784431548829, 9784431548836
  • Int'l Joint Research
• [Journal Article] Optimization of the fractionated irradiation scheme considering physical doses to tumor and organ at risk based on dose volume histograms (2015)
  • Author(s): Yasutaka Sugano, Masahiro Mizuta, Seishin Takao, Hiroki Shirato, Kenneth L. Sutherland, Hiroyuki Date
  • Journal Title: Medical Physics Volume: 42 Issue: 11 Pages: 6203-6210
  • DOI: 10.1118/1.4931969
  • NAID: 120005890016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Symbolic data analysis for post-big data (2016)
  • Author(s): Masahiro Mizuta
  • Organizer: DAGStat 2016 4th Joint Statistical Meeting
  • Place of Presentation: ゲッチンゲン・ドイツ
  • Year and Date: 2016-03-14
  • Int'l Joint Research / Invited
• [Presentation] Mathematical Models for Radiotherapy Based on Dose Volume Histogram (2015)
  • Author(s): Masahiro Mizuta
  • Organizer: IASC-ARS
  • Place of Presentation: シンガポール・シンガポール共和国
  • Year and Date: 2015-12-17
  • Int'l Joint Research
• [Presentation] Methods for Analyzing Joint Distribution Valued Data and Actual Data Sets -Mini Data Approach to Big Data- (2015)
  • Author(s): Masahiro Mizuta, Hiroyuki Minami
  • Organizer: Symbolic Data Analysis Workshop(SDA 2015)
  • Place of Presentation: オルレアン・ フランス
  • Year and Date: 2015-11-17
  • Int'l Joint Research
• [Presentation] Big Dataと統計学 (2015)
  • Author(s): 水田正弘
  • Organizer: 医用画像情報学会（MII）平成27年度秋季（第173回）大会
  • Place of Presentation: 北海道大学（北海道・札幌）
  • Year and Date: 2015-10-17
  • Invited
• [Presentation] A Novel Technique for Optimizing the Dose Fractionation Regimen Based on the Universal Survival Curve with Tumor Repopulation (2014)
  • Author(s): Yasutaka Sugano, Masahiro Mizuta, Seishin Takao, Hiroki Shirato, Kenneth L. Sutherland, and Hiroyuki Date
  • Organizer: RSNA's 100th Scientific Assembly and Annual Meeting
  • Place of Presentation: シカゴ市（アメリカ合衆国）
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] シンボリックデータ解析および関数データ解析における次元縮小 (2014)
  • Author(s): 水田正弘
  • Organizer: 2014年度統計関連学会連合大会
  • Place of Presentation: 東京大学（東京都文京区）
  • Year and Date: 2014-09-13 – 2014-09-16
• [Presentation] Analysis of sensing data with moving functional methods (2014)
  • Author(s): Masahiro Mizuta, Yusuke Matsui
  • Organizer: 21st International Conference on Computational Statistics
  • Place of Presentation: ジュネーブ市（スイス）
  • Year and Date: 2014-08-19 – 2014-08-22
• [Presentation] Moving Functional MDS and its Application to Monitoring Post Data in Fukushima Prefecture (2014)
  • Author(s): Masahiro Mizuta, Hiroyuki Minami
  • Organizer: Second European Conference on Data Analysis (ECDA 2014)
  • Place of Presentation: ブレーメン市（ドイツ）
  • Year and Date: 2014-07-02 – 2014-07-04
• [Presentation] Symbolic Data Analysis for Big Data (2014)
  • Author(s): Masahiro Mizuta
  • Organizer: 2014 Workshop in Symbolic Data Analysis
  • Place of Presentation: 台北市（台湾）
  • Year and Date: 2014-06-13 – 2014-06-16
• [Presentation] A Mathematical Study on Optimizationof Dose Fractionation based on Linear Quadratic Model (2013)
  • Author(s): Masahiro Mizuta
  • Organizer: The 2nd Hokkaido University-Korea University Joint Workshop in Statistics
  • Place of Presentation: Korea University（韓国）
• [Presentation] 分布値データと放射線治療について (2013)
  • Author(s): 水田正弘
  • Organizer: 2013年度統計関連学会連合大会
  • Place of Presentation: 大阪大学（大阪府豊中市）
• [Presentation] 寡分割照射放射線治療における最適分割方式の検討 (2013)
  • Author(s): 菅野康貴、水田正弘、高尾聖心、小宮由里子、白土博樹、伊達広行
  • Organizer: 日本放射線腫瘍学会 第26回学術大会
  • Place of Presentation: リンクステーションホール青森（青森県青森市）