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Development of basic technology for privacy-preserving bioinformatics and its application

Research Project

Project/Area Number 25540131
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Life / Health / Medical informatics
Research InstitutionWaseda University (2014-2015)
The University of Tokyo (2013)

Principal Investigator

Hamada Michiaki  早稲田大学, 理工学術院, 准教授 (00596538)

Co-Investigator(Kenkyū-buntansha) Shimizu Kana  早稲田大学, 理工学術院, 准教授 (60367050)
Co-Investigator(Renkei-kenkyūsha) Hanaoka Goichiro  独立行政法人産業技術総合研究所, 研究グループ長 (30415731)
Tsuda Koji  東京大学, 大学院新領域創成科学研究科, 教授 (90357517)
Frith Martin  産業技術総合研究所, 人工知能研究センター, 主任研究員 (40462832)
Asai Kiyoshi  東京大学, 大学院新領域創成科学研究科, 教授 (30356357)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsプライバシー保護 / 化合物検索 / アラインメント / 隠れマルコフモデル / PPDM / 配列アラインメント / 準同型暗号 / プライバシー / ゲノム / 化合物 / 暗号 / データベース検索 / 配列検索
Outline of Final Research Achievements

It is highly demanded to deal with the information of personal genome and chemical compound secretly, because they are sensitive information that should not be leaked. On the other hand, from a viewpoint of "open" science, it is important to perform data-mining by combining those sensitive information with other data. In this study, we have developed several methods to perform data-mining, making those information secret. Specifically, we developed (i) privacy-preserving search for chemical database, (ii) privacy-preserving genome sequence search with hidden Markov Model (HMM) and (iii) privacy preserving sequence alignment, all of which will be useful toward open science of biology.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Privacy-preserving search for chemical compound databases2015

    • Author(s)
      Kana Shimizu, Koji Nuida, Hiromi Arai, Shigeo Mitsunari, Nuttapong Attrapadung, Michiaki Hamada, Koji Tsuda, Takatsugu Hirokawa, Jun Sakuma, Goichiro Hanaoka, Kiyoshi Asai
    • Journal Title

      BMC Bioinformatics

      Volume: 16(Suppl 18):S6 Issue: S18 Pages: 1-14

    • DOI

      10.1186/1471-2105-16-s18-s6

    • NAID

      120007128511

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 疾患リスクの評価へ向けた加法準同型性暗号によるプライバシー保護HMMの実装と評価2016

    • Author(s)
      三品 気吹, 浜田道昭
    • Organizer
      情報処理学会 第108回MPS・第46回BIO合同研究発表会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Privacy-preserving search for a chemical compound database2013

    • Author(s)
      Kana Shimizu, Hiromi Arai, Koji Nuida, Michiaki Hamada, Koji Tsuda, Jun Sakuma, Takatsugu Hirokawa, Goichiro Hanaoka, Kiyoshi Asai,
    • Organizer
      ISMB/ECCB 2013
    • Place of Presentation
      ベルリン、ドイツ
    • Related Report
      2013 Research-status Report
  • [Presentation] 次世代バイオインフォマティクス技術の研究開発2013

    • Author(s)
      浜田道昭
    • Organizer
      医薬会セミナー
    • Place of Presentation
      国立国際医療研究センター、東京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 生命情報処理における機械学習2016

    • Author(s)
      瀬々潤、浜田道昭
    • Publisher
      講談社
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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