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Experimental and theoretical investigations on effects of focal brain cooling on the generalized seizures

Research Project

Project/Area Number 25540136
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Life / Health / Medical informatics
Research InstitutionYamaguchi University

Principal Investigator

SUZUKI Michiyasu  山口大学, 医学(系)研究科(研究院), 教授 (80196873)

Co-Investigator(Kenkyū-buntansha) ISHIZUKA Satoru  九州工業大学, 大学院生命体工学研究科, 准教授 (40124804)
Co-Investigator(Renkei-kenkyūsha) INOUE Takao  山口大学, 医学部附属病院, 助教 (80513225)
Research Collaborator HE Yeting  山口大学, 大学院医学系研究科
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords局所脳冷却 / てんかん / ビククリン / 全般性てんかん / 全般てんかん / 脳波 / 脳温
Outline of Final Research Achievements

The goal of the study was to investigate the effects of focal brain cooling (FBC) on bicuculline-induced generalized tonic-clonic seizures (GTCSs) in rats. A cooling device was implanted in the right somatosensory cortex in rats. Five days after implantation, GTCSs were produced by intraperitoneal injection of bicuculline under free-moving conditions. Ten minutes after GTCS onset, the temperature of the cortical surface was reduced to 15, 10 or 5゜C for 10 min. ECoG and seizure symptoms were continuously monitored and the severity of each GTCS was scored using the Racine stage.Temperature reduction to 15, 10 and 5 significantly improved Racine stages and suppressed epileptiform discharges (EDs). These findings indicate that FBC has an anticonvulsant effect on GTCSs and may suppress EDs in the cooled cortex and in the remote cortex, which has nerve fiber connections from the cooled cortex via the corpus callosum.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Penicillin-induced epileptiform activity elevates focal brain temperature in anesthetized rats.2013

    • Author(s)
      Tokiwa T, Inoue T, Fujii M, Ishizuka S, Aou S, Kida H, Maruta Y, Yamakawa T, Nomura S, Suzuki M, Yamakawa T.
    • Journal Title

      Neurosci Res.

      Volume: 76 Issue: 4 Pages: 257-260

    • DOI

      10.1016/j.neures.2013.05.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Anticonvulsant properties of focal brain cooling in experimental generalized tonic-clonic seizures2014

    • Author(s)
      Yeting He, Takao Inoue, Masami Fujii, Yuichi Maruta, Hiroyuki Kida, Yuji Owada, Toshitaka Yamakawa, Takeshi Yamakawa, Michiyasu Suzuki
    • Organizer
      Neuroscience2014
    • Place of Presentation
      Washington Convention Center, USA
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Anticonvulsant effects of focal brain cooling on rat generalized seizures model2014

    • Author(s)
      賀業霆、井上貴雄、藤井正美、野村貞宏、丸田雄一、井本浩哉、山川俊貴、木田裕之、鈴木倫保
    • Organizer
      第37回日本てんかん外科学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] ニューロモデュレーション『局所脳冷却』による難治性神経疾患治療2013

    • Author(s)
      井上貴雄、藤井正美、丸田雄一、井本浩哉、賀業霆、小泉博靖、野村貞宏、山川俊貴、大和田祐二、山川烈、鈴木倫保
    • Organizer
      第28回信号処理シンポジウム
    • Place of Presentation
      海峡メッセ下関(山口)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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