Contribution of translesional DNA synthesis to UV-induced damage during embryogenesis and at low dose-rate.
| Project/Area Number |
25550025
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
KOMATSU Kenshi 京都大学, 放射線生物研究センター, 教授 (80124577)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 損傷乗り越えDNA合成 / NBS1 / 紫外線感受性 |
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| Research Abstract |
Translesional DNA synthesis (TLS) and nucleotide excision repair (NER) are two major pathways to repair UV-induced DNA damage, although their contributions under the sun-light or during the embryogenesis remain elusive. We developed here the UV-exposure apparatus at low dose rate, like sun-light, and also established the TLS-defective cell line. Present results showed that TLS is a critical repair pathway under low dose-rate of UV exposure, in comparison with that of NER, and both pathways have a differential role in the embryogenesis.
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Report
(2 results)
Research Products
(27 results)
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[Journal Article] Mutations in the FHA-domain of ectopically expressed NBS1 lead to Radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination2014
Author(s)
Maki Ohara, Yumi Funyu, Shunsuke Ebara, Yuki Sakamoto, Ryota Seki, Kenta Iijima, Akiko Ohishi, Junya Kobayashi, Kenshi Komatsu, Akira Tachibana, and Hiroshi Tauchi
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Journal Title
J. Radiat. Res
Volume: (in press)
URL
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Peer Reviewed
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[Presentation] マウスを用いた小児期被ばくの放射線感受性とDNA 修復能の解析2013
Author(s)
加藤晃弘, 柳原啓見, 本田浩章, 柿沼志津子, 島田義也, 西村まゆみ, 品川まゆみ, 中村恭介, 藤本浩子, 小林純也, 小松賢志
Organizer
日本放射線影響学会第56回大会
Place of Presentation
青森
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