Contribution of translesional DNA synthesis to UV-induced damage during embryogenesis and at low dose-rate.
| Project/Area Number |
25550025
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
KOMATSU Kenshi 京都大学, 放射線生物研究センター, 教授 (80124577)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 損傷乗り越えDNA合成 / NBS1 / 紫外線感受性 |
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| Research Abstract |
Translesional DNA synthesis (TLS) and nucleotide excision repair (NER) are two major pathways to repair UV-induced DNA damage, although their contributions under the sun-light or during the embryogenesis remain elusive. We developed here the UV-exposure apparatus at low dose rate, like sun-light, and also established the TLS-defective cell line. Present results showed that TLS is a critical repair pathway under low dose-rate of UV exposure, in comparison with that of NER, and both pathways have a differential role in the embryogenesis.
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Report
(2 results)
Research Products
(27 results)
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[Journal Article] Oliveira DV, Kato A, Nakamura K, Ikura T, Okada M, Kobayashi J, Yanagihara H, Saito Y, Tauchi H, Komatsu K2014
Author(s)
Oliveira DV, Kato A, Nakamura K, Ikura T, Okada M, Kobayashi J, Yanagihara H, Saito Y, Tauchi H, Komatsu K
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Journal Title
J Cell Sci, 127: 763-772, 2014
Volume: 127
Pages: 763-772
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mutations in the FHA-domain of ectopically expressed NBS1 lead to Radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination2014
Author(s)
Maki Ohara, Yumi Funyu, Shunsuke Ebara, Yuki Sakamoto, Ryota Seki, Kenta Iijima, Akiko Ohishi, Junya Kobayashi, Kenshi Komatsu, Akira Tachibana, and Hiroshi Tauchi
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Journal Title
J. Radiat. Res
Volume: (in press)
URL
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Peer Reviewed
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[Presentation] マウスを用いた小児期被ばくの放射線感受性とDNA 修復能の解析2013
Author(s)
加藤晃弘, 柳原啓見, 本田浩章, 柿沼志津子, 島田義也, 西村まゆみ, 品川まゆみ, 中村恭介, 藤本浩子, 小林純也, 小松賢志
Organizer
日本放射線影響学会第56回大会
Place of Presentation
青森
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