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Development of bio-dosimetry methods using radiation responsive urinary biomarker

Research Project

Project/Area Number 25550031
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionHiroshima University

Principal Investigator

KAMIYA Kenji  広島大学, 原爆放射線医科学研究所, 教授 (60116564)

Co-Investigator(Kenkyū-buntansha) IIZUKA Daisuke  広島大学, 原爆放射線医科学研究所, 助教 (00455388)
SASATANI Megumi  広島大学, 原爆放射線医科学研究所, 助教 (80423052)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生物影響 / 生物学的線量評価法 / 糖鎖修飾 / 生物学的線量評価 / 放射線被ばく / バイオマーカー / 質量分析計
Outline of Final Research Achievements

The different biological effect of radiation exposure is induced by different radiation doses. From this viewpoint, the rapid, accurate dose estimation is anticipated when radiation accident is occurred. Until now, counting chromosome aberration in peripheral blood lymphocyte is the most accurate method for evaluating exposed dose, but this method is time consuming and requires expert skills. Our final goal is to establish rapid, high-throughput radiation bio-dosimetry/radiation risk assessment method using noninvasive specimen materials. The glycosylation status of mouse urine Adipsin protein was modulated for 8 to 48 h after 0.25 to 6 Gy of radiation exposure. The establishment of radiation bio-dosimetry method using the protein glycosylation status will be expected in the future.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (35 results)

All 2015 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 2 results) Presentation (26 results)

  • [Journal Article] RAD18 Activates the G2/M Checkpoint through DNA Damage Signaling to Maintain Genome Integrity after Ionizing Radiation Exposure.2015

    • Author(s)
      Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: 1-16

    • DOI

      10.1371/journal.pone.0117845

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation2014

    • Author(s)
      CAO Lili, KAWAI Hidehiko, SASATANI Megumi, IIZUKA Daisuke, MASUDA Yuji, INABA Toshiya, SUZUKI Keiji, OOTSUYAMA Akira, UMATA Toshiyuki, KAMIYA Kenji, SUZUKI Fumio
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e104279-e104279

    • DOI

      10.1371/journal.pone.0104279

    • NAID

      120006986457

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation2014

    • Author(s)
      Imaoka T, Okutani T, Daino K, Iizuka D, Nishimura M, Shimada Y
    • Journal Title

      Anticancer Res.

      Volume: 34(5) Pages: 2165-2171

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 迅速・簡易的線量評価法開発を目指した放射線被ばくのバイオマーカー探索.2014

    • Author(s)
      飯塚大輔, 河合秀彦, 泉俊輔, 神谷研二, 鈴木文男
    • Journal Title

      放射線生物研究

      Volume: 49 Pages: 382-395

    • NAID

      40020314290

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells. Cell Cycle2014

    • Author(s)
      Shimura T, Hamada N, Sasatani M, Kamiya K, Kunugita N
    • Journal Title

      Cell Cycle

      Volume: 13 Issue: 8 Pages: 1248-1255

    • DOI

      10.4161/cc.28139

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 白血病モデルマウス(Bcr-Ablトランスジェニックマウス)を用いた放射線発がん高感受性マウスの開発2014

    • Author(s)
      笹谷めぐみ, 徐 衍賓, 本田浩章, 飯塚大輔, 渡邊敦光, 神谷研二
    • Journal Title

      広島医学

      Volume: 67(4) Pages: 340-342

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Measurements of individual radiation doses in residents living around the Fukushima Nuclear Power Plant2013

    • Author(s)
      Nagataki S., Takamura N., Kamiya K., Akashi M
    • Journal Title

      Radiation Research

      Volume: 180(5) Pages: 439-447

    • NAID

      120006986019

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Determination of the biochemical properties of full-length human PIF1 ATPase2013

    • Author(s)
      Gu Y., Wang J., Li S, Kamiya K., Chen X., Zhou P.
    • Journal Title

      Prion

      Volume: 7(4) Issue: 4 Pages: 341-347

    • DOI

      10.4161/pri.26022

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair2013

    • Author(s)
      J Tomida, A Itaya, T Shigechi, J Unno, E Uchida, M Ikura, Y Masuda, S Matsuda J Adachi, M Kobayashi, AR Meetei, Y Maehara, K Yamamoto K Kamiya, A Matsuura, T Matsuda. T Ikura, M Ishiai, M Takata
    • Journal Title

      Nucleic Acids Research

      Volume: VOL. 41 Issue: 14 Pages: 6930-6941

    • DOI

      10.1093/nar/gkt467

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 乳腺幹細胞における低線量放射線被ばく影響解析2014

    • Author(s)
      飯塚大輔, 笹谷めぐみ, 神谷研二
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] RAD 18 mediates DNA damage signaling to activate G2/M checkpoint for maintaining genome integrity after ionizing radiation exposure2014

    • Author(s)
      Yanbin Xu, Sasatani M, Kawai H, Lili Cao, Iizuka D, Kamiya K.
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] γ線照射環境での線量率依存的な老化様細胞増殖停止はATM/TP53/P21経路依存的である2014

    • Author(s)
      曹麗麗, 河合秀彦, 笹谷めぐみ, 飯塚大輔, 稲葉俊哉, 神谷研二, 鈴木文男
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] BCR-ABL トランスジェニックマウスを用いた放射線発がんの分子機構解明2014

    • Author(s)
      笹谷めぐみ, 徐衍賓, 本田浩章, 飯塚大輔, 神谷研二
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Radiation exposure increases mammary stem cell self-renewal in Balb/c mice2014

    • Author(s)
      飯塚大輔, 笹谷めぐみ, Mary Helen Barcellos-Hoff, 神谷研二
    • Organizer
      60th Annual Internatioal Meeting Radiation Research Society
    • Place of Presentation
      ラスベガス
    • Year and Date
      2014-09-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 乳腺幹細胞頻度から見た乳がんリスク評価の試み2014

    • Author(s)
      飯塚大輔, 笹谷めぐみ, 神谷研二
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖鎖修飾の変化を指標とした放射線被ばくのバイオマーカー探索2014

    • Author(s)
      飯塚大輔, 桐山慧大, 岡崎恵美, 河合秀彦, 泉俊輔,  神谷研二
    • Organizer
      第55回原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2014-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] γ線照射環境下での線量率依存的な細胞運命決定とその分子機構の解析2014

    • Author(s)
      曹麗麗, 河合秀彦, 笹谷めぐみ, 飯塚大輔, 松井啓隆, 金井昭教, 稲葉俊哉, 神谷研二, 鈴木文男
    • Organizer
      第55回原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2014-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] E3ユビキチンライゲースRAD18が放射線損傷応答におよぼす寄与2014

    • Author(s)
      徐衍賓, 笹谷めぐみ, 河合秀彦, 飯塚大輔, 神谷研二
    • Organizer
      第55回原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2014-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cyclin D1 as a molecular marker and possible molecular radioprotection target for long-term exposure to low-dose ionizing radiation2014

    • Author(s)
      T. Shimura, M. Sasatani, K. Kamiya, N. Hamada, N. Kunugita
    • Organizer
      4th International Symposium of RIRBM -Hiroshima-Nagasaki Collaborative Research on Radiation Disaster Medicine-
    • Place of Presentation
      Hiroshima
    • Related Report
      2013 Research-status Report
  • [Presentation] The use of γ―H2AX assay for validation of novel radioprotector against both acute and chornic low-dose radiation exposure2014

    • Author(s)
      A. Nakamura, M. Sasatani and K. Kamiya
    • Organizer
      4th International Symposium of RIRBM -Hiroshima-Nagasaki Collaborative Research on Radiation Disaster Medicine-, Hiroshima
    • Place of Presentation
      Hiroshima
    • Related Report
      2013 Research-status Report
  • [Presentation] A combination of experimental and bioinformatics approaches for assessing the biological effects of ionizing radiation2014

    • Author(s)
      H. Kawai, L. Cao, D. Iizuka, H Matsui, A. Kanai, T. Inaba, M. Sasatani, K. Kamiya, F. Suzuki
    • Organizer
      4th International Symposium of RIRBM -Hiroshima-Nagasaki Collaborative Research on Radiation Disaster Medicine-
    • Place of Presentation
      Hiroshima
    • Related Report
      2013 Research-status Report
  • [Presentation] Function of RAD18 on radioresponse2014

    • Author(s)
      Y. Xu, M. Sasatani, H. Kawai, K. Kamiya
    • Organizer
      The 3rd International Symposium Phoenix Leader Education Program(Hiroshima Initiative) for Renaissance from Radiation Disaster -Nature, Human being, and Radiation-
    • Place of Presentation
      Hiroshima
    • Related Report
      2013 Research-status Report
  • [Presentation] Mouse Urinary Hepcidin-2 is a potential biomarker of radiation exposure2013

    • Author(s)
      D Iizuka, S Yoshioka, H Kawai, K Kiriyama, S Izumi, M Nishimura, Y Shimada, K Kamiya, F Suzuki
    • Organizer
      The 3rd Asian Congress of Radiation Research
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Research-status Report
  • [Presentation] Rad18 Facilitates DNA damage repair after ionizing radiation2013

    • Author(s)
      Y Xu, M Sasatani, H Kawai, D Iizuka, K Kamiya
    • Organizer
      The 3rd Asian Congress of Radiation Research
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Research-status Report
  • [Presentation] マウスを用いた放射線発がんの分子機構解明2013

    • Author(s)
      笹谷めぐみ, 飯塚大輔, 神谷研二
    • Organizer
      第9回広島大学・長崎大学連携研究事業カンファンランス- 放射線災害医療の国際教育研究拠点に向けた機関連携事業
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] 慢性的な放射線照射に対する細胞応答の先端技術を用いた解析2013

    • Author(s)
      河合秀彦, 曹 麗麗, 飯塚大輔, 松井啓隆, 金井昭教, 稲葉俊哉, 笹谷めぐみ, 神谷研二, 鈴木文男
    • Organizer
      第9回広島大学・長崎大学連携研究事業カンファンランス- 放射線災害医療の国際教育研究拠点に向けた機関連携事業
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規放射線被ばく生体応答因子の同定2013

    • Author(s)
      飯塚大輔, 桐山慧太, 河合秀彦, 泉 俊輔, 鈴木文男, 神谷研二
    • Organizer
      第54回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] 恒常的な放射線被曝環境下のゲノム安定性維持にはATM-p53-p21経路の活性化が必要である2013

    • Author(s)
      曹 麗麗, 河合秀彦, 飯塚大輔, 松井啓隆, 金井昭教, 稲葉俊哉, 笹谷めぐみ, 神谷研二, 鈴木文男
    • Organizer
      第54回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] 白血病モデルマウス(Bcr-Ablトランスジェニックマウス)を用いた放射線発がん高感受性マウスの開発2013

    • Author(s)
      笹谷めぐみ, 徐 衍賓, 本田浩章, 飯塚大輔, 渡邊敦光, 神谷研二
    • Organizer
      第54回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of urinary biomarker of radiation exposure using mass spectrometry2013

    • Author(s)
      Iizuka D, Kiriyama K, Kawai H, Izumi S, Sasatani M, K Kamiya
    • Organizer
      59th Annual Meeting of the Radiation Research Society
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2013 Research-status Report
  • [Presentation] BCR-ABLトランスジェニックマウスを用いた放射線発がん高感受性マウスの開発2013

    • Author(s)
      笹谷めぐみ, 徐 衍賓, 李建祥, 本田浩章, 飯塚大輔, 渡邊敦光, 神谷研二,
    • Organizer
      第38回中国地区放射線影響研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] Bcr-Abl トランスジェニックマウスは、放射線誘発胸腺リンパ腫発症を促進させる2013

    • Author(s)
      笹谷めぐみ, 徐 衍賓, 本田浩章, 飯塚大輔, 渡邊敦光, 神谷研二
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 白血病モデルマウスを用いた放射線発がんの分子機構解明2013

    • Author(s)
      笹谷めぐみ, 徐 衍賓, 本田浩章, 神谷研二
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 量的・質的変化に着目した放射線被ばくの尿中バイオマーカー探索2013

    • Author(s)
      飯塚大輔, 桐山慧太, 河合秀彦, 泉 俊輔, 鈴木文男, 神谷研二
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] γ線照射環境下における細胞応答の線量率依存性の解析2013

    • Author(s)
      河合秀彦,曹麗麗,飯塚大輔,松井啓隆,金井昭教,稲葉俊哉,笹谷めぐみ,神谷研二,鈴木文男
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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