Development of bio-dosimetry methods using radiation responsive urinary biomarker
| Project/Area Number |
25550031
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAMIYA Kenji 広島大学, 原爆放射線医科学研究所, 教授 (60116564)
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| Co-Investigator(Kenkyū-buntansha) |
IIZUKA Daisuke 広島大学, 原爆放射線医科学研究所, 助教 (00455388)
SASATANI Megumi 広島大学, 原爆放射線医科学研究所, 助教 (80423052)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生物影響 / 生物学的線量評価法 / 糖鎖修飾 / 生物学的線量評価 / 放射線被ばく / バイオマーカー / 質量分析計 |
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| Outline of Final Research Achievements |
The different biological effect of radiation exposure is induced by different radiation doses. From this viewpoint, the rapid, accurate dose estimation is anticipated when radiation accident is occurred. Until now, counting chromosome aberration in peripheral blood lymphocyte is the most accurate method for evaluating exposed dose, but this method is time consuming and requires expert skills. Our final goal is to establish rapid, high-throughput radiation bio-dosimetry/radiation risk assessment method using noninvasive specimen materials. The glycosylation status of mouse urine Adipsin protein was modulated for 8 to 48 h after 0.25 to 6 Gy of radiation exposure. The establishment of radiation bio-dosimetry method using the protein glycosylation status will be expected in the future.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] RAD18 Activates the G2/M Checkpoint through DNA Damage Signaling to Maintain Genome Integrity after Ionizing Radiation Exposure.2015
Author(s)
Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K.
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Journal Title
PLoS One
Volume: 10
Issue: 2
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation2014
Author(s)
CAO Lili, KAWAI Hidehiko, SASATANI Megumi, IIZUKA Daisuke, MASUDA Yuji, INABA Toshiya, SUZUKI Keiji, OOTSUYAMA Akira, UMATA Toshiyuki, KAMIYA Kenji, SUZUKI Fumio
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Journal Title
PLoS One
Volume: 9
Issue: 8
Pages: e104279-e104279
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair2013
Author(s)
J Tomida, A Itaya, T Shigechi, J Unno, E Uchida, M Ikura, Y Masuda, S Matsuda J Adachi, M Kobayashi, AR Meetei, Y Maehara, K Yamamoto K Kamiya, A Matsuura, T Matsuda. T Ikura, M Ishiai, M Takata
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Journal Title
Nucleic Acids Research
Volume: VOL. 41
Issue: 14
Pages: 6930-6941
DOI
Related Report
Peer Reviewed
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[Presentation] Function of RAD18 on radioresponse2014
Author(s)
Y. Xu, M. Sasatani, H. Kawai, K. Kamiya
Organizer
The 3ｒｄ International Symposium Phoenix Leader Education Program(Hiroshima Initiative) for Renaissance from Radiation Disaster -Nature, Human being, and Radiation-
Place of Presentation
Hiroshima
Related Report
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