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HTP screening of radiation protectors using chemical libraries

Research Project

Project/Area Number 25550034
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionNagasaki University

Principal Investigator

SUZUKI Keiji  長崎大学, 原爆後障害医療研究所, 准教授 (00196809)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords放射線 / 防護 / DNA損傷 / 情報伝達 / 防護剤
Outline of Final Research Achievements

The study aimed at performing the high-throughput screening of radiation protectors using low-molecular weight chemical libraries. We succeded in developing a system, by which DNA damage-dependent focus formation of 53BP1 protein is detectable on live-cell imaging. Then, we have screened the core chemical libraries obtained from the Tokyo University Open Inovation Center.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Radiation signatures in childhood thyorid cancers after the Chernobyl accident: Possible roles of radiation in carcinogenesis2015

    • Author(s)
      Keiji Suzuki, Norisato Mitsutake, Vladimir Saenko, Shunichi Yamashita
    • Journal Title

      Cancer Sci

      Volume: 106 Pages: 127-133

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Radiation-induced response: Mechanism and clinical implications2014

    • Author(s)
      Keiji Suzuki, Shunichi Yamashita
    • Journal Title

      Adv Wound Care

      Volume: 3 Pages: 16-24

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] DNA damage and tissue reaction in tissues/organs exposed to low-dose and low-dose-rate radiation in mice2014

    • Author(s)
      Keiji Suzuki
    • Organizer
      第52回日本癌治療学会
    • Place of Presentation
      横浜(パシフィコ横浜、横浜市西区)
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] Brain Nerve2015

    • Author(s)
      Keiji Suzuki
    • Total Pages
      8
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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