HTP screening of radiation protectors using chemical libraries
| Project/Area Number |
25550034
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUZUKI Keiji 長崎大学, 原爆後障害医療研究所, 准教授 (00196809)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 放射線 / 防護 / DNA損傷 / 情報伝達 / 防護剤 |
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| Outline of Final Research Achievements |
The study aimed at performing the high-throughput screening of radiation protectors using low-molecular weight chemical libraries. We succeded in developing a system, by which DNA damage-dependent focus formation of 53BP1 protein is detectable on live-cell imaging. Then, we have screened the core chemical libraries obtained from the Tokyo University Open Inovation Center.
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Report
(3 results)
Research Products
(4 results)
