Development of the intestinal function imitated model in vitro system for searches of the newly allergic induction/exacerbation compounds
| Project/Area Number |
25550040
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Setsunan University |
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Principal Investigator |
OHTA Souichi 摂南大学, 薬学部, 教授 (10213729)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 食物アレルギー / 疾病予防 / 環境汚染物質 / 恒常性攪乱物質 / ダイオキシン / 簡易迅速試験法 / アレルギー誘発・増悪物質 / インビトロ検出システム / 食品汚染 |
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| Outline of Final Research Achievements |
It is suggested that the immune diseases such as allergies causes it with the disruption of epithelial cell barrier. In this study, we performed the basic data for development of the hybrid detection system that could evaluate the barrier function and the immune response by an environmental pollution at the same time. It was observed that various environmental pollutants were decreased barrier function, and disrupted the immune response. This observation suggested the possibility to develop the hybrid detection system that could evaluate the barrier function and the immune response by an environmental pollution at the same time.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Levels of tetrabromobisphenol A, tribromobisphenol A, dibromobisphenol A, monobromobisphenol A, and bisphenol A in Japanese breast milk.2015
Author(s)
Nakao, T., Akiyama, E., Kakutani, H., Mizuno, A., Aozasa, O., Akai, Y., Ohta, S.
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Journal Title
Chemical Research in Toxicology
Volume: 28
Issue: 4
Pages: 722-728
DOI
Related Report
Peer Reviewed
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[Journal Article] Detection of tribromobisphenol A as debrominated compounds of tetrabromobisphenol A in breast milk collected in Japan.2015
Author(s)
Nakao, T., Akiyama, E., Kakutani, H., Mizuno, A., Aozasa, O., Akai, Y., Ohta, S.
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Journal Title
J. Environ Chem.
Volume: 25
Pages: 61-68
NAID
Related Report
Peer Reviewed
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[Journal Article] Facilitation of adipocyte differentiation of 3T3-L1 cells by debrominated tetrabromobisphenol A compounds detected in Japanese breast milk2015
Author(s)
Akiyama, E., Kakutani, H., Nakao, T., Motomura, Y., Takano, Y., Sorakubo, R., Mizuno, A., Aozasa, O., Tachibana, K., Doi, T., Ohta, S.
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Journal Title
Environmenta Research
Volume: 140
Pages: 157-164
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother’s milk in Japan.2014
Author(s)
Akiyama, E., Kakutani, H., Nakao, T., Motomura, Y., Takano, Y., Sorakubo, R., Mizuno, A., Aozasa, O., Tachibana, K., Doi, T., Ohta, S.
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Journal Title
Toxicology
Volume: 324
Pages: 157-164
DOI
Related Report
Peer Reviewed
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