| Project/Area Number |
25550047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental impact assessment
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| Research Institution | Okazaki Research Facilities, National Institutes of Natural Sciences |
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Principal Investigator |
AONO Shigetoshi 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (60183729)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | センサータンパク質 / ヘムセンサー |
|---|
| Outline of Final Research Achievements |
In this work, the structural basis of sensor proteins was elucidated for the construction of sensitive sensing systems of environmental pollutions. Especially, the structural and functional relationships of two heme transport proteins, HupD from Listeria monocytogenes and HmuT from Corynebacterium glutamicum, that have heme sensing ability was elucidated by X-ray crystallography and spectroscopic studies to understand the molecular mechanisms of heme sensing and binding.
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