| Project/Area Number |
25560043
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Tohoku University |
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Principal Investigator |
IKEDA Ikuo 東北大学, (連合)農学研究科(研究院), 教授 (40136544)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | visceral fat / high fat diet / low fat diet / triacylglycerol / db/db mouse / C57BL/6J mouse / SD rat / 高脂肪食 / エネルギー代謝 / 内臓脂肪 / 肝臓トリアシルグリセロール / 高脂肪低炭水化物食 / 低脂肪高炭水化物食 / 肥満 / 肝臓中性脂肪 |
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| Outline of Final Research Achievements |
To study if differential levels of dietary fat and carbohydrate change the deposition of visceral fat in experimental animals, I explored several model animals in which isocaloric high fat-low carbohydrate and low fat-high carbohydrate diets influence the deposition of visceral fats. Measurement of energy metabolism revealed that db/db mice have a low ability to consume dietary fat. However, the other animal strains I examined had relatively higher ability to consume dietary fat compared with db/db mice. As a result, growth of db/db mice fed a high fat-low carbohydrate diet was higher than that fed a low fat-high carbohydrate diet. However, visceral fat weight was not significantly increased in the feeding of a high fat-low carbohydrate diet. Therefore, it is thought that dietary fat should be increased to get clear results in studies of db/db mice. This study suggest that db/db mice can be utilized as a model to reveal mechanisms of obesity induced by isocaloric high fat diet.
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