| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Procyanidins, in particular cinnamtannin A2 possessed secretion of incretin hormone, GLP-1, and subsequently increased secretion of insulin from beta-cells. This effect led to improve postprandial hyperglycemia by promoting GLUT4 translocation to the plasma membrane. As the molecular mechanism, cinnamtannin A2 activated both insulin- and AMPK-signaling pathways. Other Procyanidins also increased part of insulin-signaling pathway in addition to the AMPK-signaling pathway. From these results, procyanidins are effective food factors for prevention of hyperglycemia.
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