Does procyanidin show an incretin effect?
| Project/Area Number |
25560049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Kobe University |
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Principal Investigator |
ASHDIA Hitoshi 神戸大学, (連合)農学研究科(研究院), 教授 (90201889)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | プロシアニジン / インクレチン / 保健機能食品 |
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| Outline of Final Research Achievements |
Procyanidins, in particular cinnamtannin A2 possessed secretion of incretin hormone, GLP-1, and subsequently increased secretion of insulin from beta-cells. This effect led to improve postprandial hyperglycemia by promoting GLUT4 translocation to the plasma membrane. As the molecular mechanism, cinnamtannin A2 activated both insulin- and AMPK-signaling pathways. Other Procyanidins also increased part of insulin-signaling pathway in addition to the AMPK-signaling pathway. From these results, procyanidins are effective food factors for prevention of hyperglycemia.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Cinnamtannin A2, a Tetrameric Procyanidin, Increases GLP-1 and Insulin Secretion in Mice2013
Author(s)
Yamashita, Y., Okabe, M., Natsume, M. and H. Ashida.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 77
Issue: 4
Pages: 888-891
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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