| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Reactive oxygen species (ROS) play an important role in the inflammation processes as well as in transduction of signals from receptors for several cytokines such as tumor necrosis factor α (TNFα). ROS activate nuclear factor kB (NF-kB) via IkB kinase (IKK) through PI3K/AKT/PTEN pathway. Regulation of the PI3K/AKT pathways may also constitute an important signaling center in the subcellular integration of the synaptic neurotransmission. The pathways modulate cell proliferation, migration, and plasticity. The PI3K/AKT/PTEN pathway has been shown to play a pivotal role in several disease protections. Although PTEN has been discovered as a tumor suppressor, PTEN is also involved in several other diseases, including diabetes and Alzheimer's disease. Dietary fish oil rich in polyunsaturated fatty acids may induce the PTEN expression by activation of peroxisome proliferator-activated receptor.
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