Molecular basis of immunomodulatory effect of dietary alpha-glucans
| Project/Area Number |
25560051
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAWAMOTO Seiji 広島大学, 先端物質科学研究科, 教授 (90294537)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | α-グルカン / 米由来α-グルカン / 自然免疫賦活化 |
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| Outline of Final Research Achievements |
Objective of this study was to test the hypothesis that rice-derived alpha-glucan plays a role in health-promotion of Japanese people through modulation of host-defense system.
Oral feeding with rice-derived starch significantly suppressed the development of nasal symptoms in a murine model of allergic rhinitis without affecting adaptive immunity. The anti-inflammatory effect was more potent in uruchi-rice than in mochi-rice, suggesting that a major anti-allergic alpha-glucan unit was amylose. I also found a possibility that one could modulate such anti-allergic potency by regulation of rice starch consumptions.
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Report
(3 results)
Research Products
(1 results)
