Analysis of the regulation mechanism of disease-specific intestinal transporter genes and establishment of clarification and development foundation of functional food

• Project/Area Number: 25560052
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Jin-ai University
• Principal Investigator: YAMAMOTO HIRONORI 仁愛大学, 人間生活学部, 教授 (60314861)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 腸管トランスポーター / 保健機能食品

Outline of Final Research Achievements

In this study, to develop the disease-specific functional food as the molecular target of intestinal transporter, the analysis of the intestinal gene using some disease animals including renal failure and diabetes etc has been observed. We gained that the expression database of transporter genes involved in the absorption of nutrients such as iron, zinc, calcium, peptides and amino acids. Further, the identification of disease-specific nutrient sensors genes targeted disease prevention or treatment, was found to some nuclear receptors and clock genes. In addition, restriction of dietary phosphorous during renal failure indicated the improvement of renal anemia as well as prevention of vascular calcification, and controls the expression of the intestinal iron transporter genes.

Research Products

• [Journal Article] Niacin and Chronic Kidney Disease (2015)
  • Author(s): Taketani Y, Masuda M, Yamanaka-Okumura H, Tatsumi S, Segawa H, Miyamoto K, Takeda E, Yamamoto H.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 61 Issue: Supplement Pages: S173-S175
  • DOI: 10.3177/jnsv.61.S173
  • NAID: 130005109895
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed / Open Access
• [Journal Article] Dietary combination of sucrose and linoleic acid causes skeletal muscle metabolic abnormalities in Zucker fatty rats through specific modification of fatty acid composition (2014)
  • Author(s): Hirokazu Ohminami, Kikuko Amo, Yutaka Taketani, Kazusa Sato, Makiko Fukaya, Takashi Uebanso, Hidekazu Arai, Megumi Koganei, Hajime Sasaki, Hisami Yamanaka-Okumura, Hironori Yamamoto, Eiji Takeda
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 55 Issue: 1 Pages: 15-25
  • DOI: 10.3164/jcbn.14-11
  • NAID: 130004466759
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Dietary phosphate restriction induces hepatic lipid accumulation through dysregulation of cholesterol metabolism in mice. (2013)
  • Author(s): Tanaka S, Yamamoto H, Nakahashi O, Kagawa T, Ishiguro M, Masuda M, Kozai M, Ikeda S, Taketani Y, Takeda E.
  • Journal Title: Nutr Res. Volume: 33(7) Issue: 7 Pages: 586-593
  • DOI: 10.1016/j.nutres.2013.05.004
  • Peer Reviewed
• [Presentation] 糖尿病時におけるビタミンD・カルシウム代謝異常の分子機構の解明 (2015)
  • Author(s): 山本浩範、田尻真梨、中橋乙起、石黒真理子、竹谷豊、岩野正之、武田英二
  • Organizer: 第33回小児代謝性骨疾患研究会
  • Place of Presentation: 経団連会館（東京）
  • Year and Date: 2015-12-05
• [Presentation] Niacin and Chronic Kidney Disease. (2015)
  • Author(s): Yutaka Taketani, Masashi Masuda, Hisami Yamanaka-Okumura, Sawako Tatsumi, Hiroko Segawa, Ken-ichi Miyamoto, Eiji Takeda, Hironori Yamamoto
  • Organizer: 12th Asian Congress of Nutrition (ACN2015)
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] 肝臓脂質蓄積とコレステロール代謝に及ぼす リンの影響 (2014)
  • Author(s): 田中更沙、山本浩範、伊藤美紀子、竹谷豊
  • Organizer: 第61回日本栄養改善学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 2014-08-20 – 2014-08-22
• [Presentation] 糖尿病時におけるビタミンD・カルシウム代謝異常の分子機構の解明 (2013)
  • Author(s): 山本浩範、田尻真梨、中橋乙起、香西美奈、香川智博、竹谷豊、武田英二
  • Organizer: 日本ビタミン学会第65回大会
  • Place of Presentation: 一橋大学・一橋講堂、（東京都）
• [Presentation] Association with Fetuin-A and Ectopic C alcification in α-klotho mutant mice (2013)
  • Author(s): Yokoyama N, Yamamoto H, Taketani Y, Iwano M, Takeda E
  • Organizer: 米国腎臓学会議(American Society of Nephrology (ASN) Kidney Week 2014 Annual Meeting)
  • Place of Presentation: Georgia World Congress Center、アトランタ、米国