| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Circulating miRNAs (c-miRNAs) is involved in metabolic state of between distant organs, however its functions have not been elucidated. In this study, to clarify functions of intercellular and extracellular inflammation-related miRNA in vivo, I have recently generated miRNA knockout (KO) mice and while they are grossly normal through embryogenesis, they are very vulnerable to live at early postnatal stages. Those individuals that make it through the neonatal period thrive and are fertile as adults and display no gross abnormalities. these results indicated that miRNA is contributed to homeostatic mechanism and other biological phenomenon such as inflammation and tissue repair.
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