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Elucidation of molecular mechanisms for diabetes induced by soft diet

Research Project

Project/Area Number 25560056
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionUniversity of Miyazaki

Principal Investigator

Date Yukari  宮崎大学, 理事 (70381100)

Co-Investigator(Renkei-kenkyūsha) Akieda Sayaka  宮崎大学, フロンティア科学実験総合センター, 助教 (20549076)
Senba Kazuyo  別府大学, 食物栄養科学部, 准教授 (30381031)
Miyazato Mikiya  独立行政法人国立循環器病研究センター, 生化学部, 部長 (50291183)
kangawa Kenji  独立行政法人国立循環器病研究センター, 生化学部, 所長 (00112417)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords軟食 / 糖尿病 / インスリン抵抗性 / 脂肪肝 / 膵ラ氏島過形成 / 消化管ホルモン / インスリンシグナル
Outline of Final Research Achievements

In this study, we found that rats fed soft diet on 3-h restricted feeding show glucose tolerance, insulin resistance, and lipid accumulation in the liver. These rats also demonstrated impairment of insulin signal transduction in the liver and increase in the number of islets compared with rats fed standard chow. We showed that lipid accumulation factors induced by hyperglycemia and hyper insulinemia also increase in rats fed soft diet. Taken together, it was thought that rats fed soft diet on 3-h restricted feeding could be a novel of type II diabetes without significant obesity like Japanese and Asian people.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Role of the neural pathway from hindbrain to hypothalamus in the regulation of energy homeostasis in rats.2016

    • Author(s)
      Utoyama M, Akieda-Asai S, Koda S, Nunoi H, Date Y
    • Journal Title

      Neuroscience Letters

      Volume: 614 Pages: 83-88

    • DOI

      10.1016/j.neulet.2016.01.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of inflammatory gene expression and chemotaxis of macrophages guanylin and guanylyl cyclase-C.2015

    • Author(s)
      Hasegawa K, Akieda-Asai S, Date Y
    • Journal Title

      American Journal of Life Sciences

      Volume: 3 Issue: 3 Pages: 43-47

    • DOI

      10.11648/j.ajls.s.2015030302.18

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet2015

    • Author(s)
      Hasegawa K, Akieda-Asai S, Fujii Y, Bae CR, Yasuda M, Date Y
    • Journal Title

      Endocrine Journal

      Volume: 62 Issue: 10 Pages: 939-947

    • DOI

      10.1507/endocrj.EJ15-0193

    • NAID

      130005105503

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus.2014

    • Author(s)
      Akieda-Asai S, Poleni PE, Date Y
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 306 Issue: 11 Pages: E1284-E1291

    • DOI

      10.1152/ajpendo.00664.2013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of food texture in insulin resistance and energy metabolism in male rats.2014

    • Author(s)
      Bae CR, Hasegawa K, Akieda-Asai S, Kawasaki Y, Senba K, Cha YS, Date Y
    • Journal Title

      J Endocrinol

      Volume: 222 Issue: 1 Pages: 61-72

    • DOI

      10.1530/joe-13-0553

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The short-term effects of soft pellets on lipogenesis and insulin sensitivity in rats.2014

    • Author(s)
      Bae CR, Hasegawa K, Akieda-Asai S, Kawasaki Y, Cha YS, Date Y
    • Journal Title

      Prev Nutr Food Sci

      Volume: 19 Issue: 3 Pages: 164-169

    • DOI

      10.3746/pnf.2014.19.3.164

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of the neural pathway from hindbrain to hypothalamus in interaction of GLP1 and leptin in rats.2014

    • Author(s)
      Akieda-Asai S, Poleni PE, Hasegawa K, Date Y
    • Journal Title

      J Endocrinol

      Volume: 220 Issue: 2 Pages: 109-116

    • DOI

      10.1530/joe-13-0272

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to high-fat diet.2013

    • Author(s)
      Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Yamahara K, Mutoh E, Aoyama F, Sawaguchi A, Furuya M, Miyazato M, Kangawa K, Date Y
    • Journal Title

      Journal of Lipid Research

      Volume: 54 Issue: 1 Pages: 85-96

    • DOI

      10.1194/jlr.m029017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metabolic features of rats resistant to a high-fat diet.2013

    • Author(s)
      Akieda-Asai S, Koda S, Sugiyama M, Furuya M, Miyazato M, Date Y
    • Journal Title

      Obesity Res Clin Practice

      Volume: 7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Passive carriage of rabies virus by dendritic cells.2013

    • Author(s)
      Senba K, Matsumoto T, Yamada K, Shiota S, Iha H, Date Y, Ohtsubo M, Nishizono A
    • Journal Title

      Springerplus

      Volume: 2 Issue: 1 Pages: 419-419

    • DOI

      10.1186/2193-1801-2-419

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Possible involvement of food texture in insulin resistance and energy metabolism in rats.2016

    • Author(s)
      長谷川和哉, 秋枝さやか, 伊達紫
    • Organizer
      第10回Cardio-Diabetes研究会
    • Place of Presentation
      リーガルロイヤルホテル東京(東京都新宿区)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] soft diet自由摂食ラットにおける代謝バランスと内臓脂肪蓄積2015

    • Author(s)
      宇藤山麻衣子,日髙綾乃,長谷川和哉, 山田千紘,秋枝さやか, 伊達紫
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 軟らかい食物の短期間摂取がインスリン抵抗性に及ぼす影響2015

    • Author(s)
      長谷川和哉, 秋枝さやか, 山田千紘, 日高綾乃, 宇藤山麻衣子, 宮里幹也, 寒川賢治, 伊達紫
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京(東京都千代田区)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 軟らかい食物の短期間摂取がインスリン抵抗性に及ぼす影響2014

    • Author(s)
      長谷川和哉, 秋枝さやか, 川﨑友里恵, 伊達紫
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎市
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Inflammatory changes of adipose tissue and pancreatitis in cattle with fat necrosis.2014

    • Author(s)
      Urushizaki S, Tani C, Akieda S, Ano H, Date Y, Yasuda M, Nishino K, Goto Y, Katamoto H
    • Organizer
      XXVIII World Buiatrics Congress
    • Place of Presentation
      Carins, Australia
    • Year and Date
      2014-07-27 – 2017-08-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 食物の性状の違いがエネルギーバランスおよびインスリン抵抗性に及ぼす影響2014

    • Author(s)
      長谷川和哉, 秋枝さやか, 川﨑友里恵, 伊達紫
    • Organizer
      第32回内分泌代謝学サマーセミナー
    • Place of Presentation
      山梨県南都留郡
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] ソフトペレット(軟食)給餌による肥満を伴わない2型糖尿病モデルラットの解析2014

    • Author(s)
      長谷川和哉, 秋枝さやか, 川﨑友里恵, 伊達紫
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] グアニリン/GC-C システムの肥満抵抗性に関する研究2014

    • Author(s)
      秋枝さやか, 長谷川和哉, 宮澤崇, 宮里幹也, 寒川賢治, 伊達紫
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2014-04-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 過食・肥満を伴わずインスリン抵抗性を示すソフトペレット(軟食)給餌ラットの解析

    • Author(s)
      長谷川和哉,秋枝さやか,伊達紫
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京都千代田区
    • Related Report
      2013 Research-status Report
  • [Presentation] 肥満を伴わない2型糖尿病モデル動物におけるインスリンシグナル分子とmicroRNA-33に関する研究

    • Author(s)
      伊達紫,長谷川和哉,川﨑友里恵,秋枝さやか
    • Organizer
      第17回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大阪府豊中市
    • Related Report
      2013 Research-status Report
  • [Presentation] 肥満抵抗性ラットの解析

    • Author(s)
      伊達 紫
    • Organizer
      第8回宮崎サイエンスキャンプ
    • Place of Presentation
      宮崎県宮崎市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] フロンティア科学実験総合センター 生理活性物質研究部門 生理活性物質機能解析分野

    • URL

      http://www.med.miyazaki-u.ac.jp/peptides/date/jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] フロンティア科学実験総合センター 生理活性研究部門 生理活性物質機能解析分野

    • URL

      http://www.med.miyazaki-u.ac.jp/peptides/date/jp/

    • Related Report
      2014 Research-status Report
  • [Remarks] 宮崎大学フロンティア科学実験総合センター生理活性物質機能解析

    • URL

      http://www.med.miyazaki-u.ac.jp/peptides/date/jp/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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