| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We have developed methods simultaneous high sensitive determination of 9 kinds of polyamines, 2-Hydroxy butyrate (HB), Aspartic acid (Asp), Cystamine (Cys) and quantitative analysis of diacetylpolyamines in the lung cancer patient fingernail. The proposed method was used to analyze human fingernail samples from lung cancer patients and healthy volunteers. When comparing the index from the lung cancer patients with that of the healthy volunteers, the SPM, DiAct-Spd level was higher in the lung cancer patients. There was no significant difference in the content of seven polyamines, that is, CAD, DAP, PUT, SPD, N1-actPUT, N8-actSPD and N1-actSPM, in the fingernail. However, a statistically significant (p < 0.05) correlation was observed between the SPM concentrations. Therefore, our findings suggest that measuring polyamines in human fingernails may be a simple, noninvasive technique to assist in the diagnosis and assessment of disease activity in patients with cancer.
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