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Development of the early diagnosis technology of cancer using the human nail

Research Project

Project/Area Number 25560058
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionUniversity of Shizuoka

Principal Investigator

MIN Junzhe  静岡県立大学, 薬学部, 助教 (10453060)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsヒト爪 / がん / ポリアミン / 早期診断 / 非侵襲 / 癌 / 非侵襲的
Outline of Final Research Achievements

We have developed methods simultaneous high sensitive determination of 9 kinds of polyamines, 2-Hydroxy butyrate (HB), Aspartic acid (Asp), Cystamine (Cys) and quantitative analysis of diacetylpolyamines in the lung cancer patient fingernail. The proposed method was used to analyze human fingernail samples from lung cancer patients and healthy volunteers. When comparing the index from the lung cancer patients with that of the healthy volunteers, the SPM, DiAct-Spd level was higher in the lung cancer patients. There was no significant difference in the content of seven polyamines, that is, CAD, DAP, PUT, SPD, N1-actPUT, N8-actSPD and N1-actSPM, in the fingernail. However, a statistically significant (p < 0.05) correlation was observed between the SPM concentrations. Therefore, our findings suggest that measuring polyamines in human fingernails may be a simple, noninvasive technique to assist in the diagnosis and assessment of disease activity in patients with cancer.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (19 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A quantitative analysis of the polyamine in lung cancer patient fingernails by LC-ESI-MS/MS.2014

    • Author(s)
      J.-Z. Min, A. Matsumoto, G. Li, Y.-Z. Jiang, H.-F. Yu, K. Todoroki, K. Inoue, T. Toyo'oka
    • Journal Title

      Biomed. Chromatogr.

      Volume: 28 Issue: 4 Pages: 492-499

    • DOI

      10.1002/bmc.3059

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid and sensitive determination of diacetylpolyamines in human fingernail by ultraperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.2014

    • Author(s)
      J.-Z. Min, Y. Morota, Y.-Z. Jiang, G. Li, D. Kang, H.-F. Yu, K. Inoue, K. Todoroki, T. Toyo'oka
    • Journal Title

      Eur. J. Mass Spectrom.

      Volume: 20 Issue: 6 Pages: 477-486

    • DOI

      10.1255/ejms.1301

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of the high sensitive separation analysis method of metabolites in human nail and its application to the diagnosis of chronic disease2014

    • Author(s)
      Jun Zhe Min
    • Journal Title

      Chromatography

      Volume: 35 Pages: 23-29

    • NAID

      130004684356

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of a highly sensitive separation method for the analysis of metabolites in human nails and applications in the diagnosis of chronic disease2014

    • Author(s)
      Jun Zhe Min
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 134 Pages: 1191-1198

    • NAID

      130004712973

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ヒト爪を用いた糖尿病リスク診断2013

    • Author(s)
      閔 俊哲、豊岡利正
    • Journal Title

      検査と技術

      Volume: 41 Pages: 432-434

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] N-結合型糖鎖の分離分析を指向したMS/MS用誘導体化試薬の開発2014

    • Author(s)
      永井啓裕、閔 俊哲、井之上浩一、轟木堅一郎、豊岡利正
    • Organizer
      第25回クロマトグラフィー科学会議
    • Place of Presentation
      京都
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of oligosacchride highly sensitive analysis method by enzyme and chemical labeling2014

    • Author(s)
      Jun Zhe Min, Kenichiro Todoroki, Koichi Inoue, Toshimasa Toyo’oka
    • Organizer
      The 2nd BK21Plus Workshop (2014) on Nano-biomaterials and Advanced Analytical Techniques
    • Place of Presentation
      Changwon, Korea
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大腸癌診断におけるヒト爪試料の有用性の検討2014

    • Author(s)
      西尾優汰、閔 俊哲、井之上浩一、轟木堅一郎、豊岡利正
    • Organizer
      新アミノ酸分析研究会第4回学術講演会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] LC-MS/MSによるヒト爪中ヒスタミン及びその代謝物の同時定量2014

    • Author(s)
      内部あおい、閔 俊哲、井之上浩一、轟木堅一郎、豊岡利正
    • Organizer
      新アミノ酸分析研究会第4回学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト爪中ヒスタミン及びその代謝物の高感度分析法の開発2014

    • Author(s)
      内部あおい、閔俊哲、井之上浩一、轟木堅一郎、豊岡利正
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2014
    • Place of Presentation
      静岡
    • Year and Date
      2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sensitive determination of the intermediates of advanced glycation end products in human fingernail for the diagnosis of diabetes2014

    • Author(s)
      Jun Zhe Min, Kenichiro Todoroki, Koichi Inoue, Toshimasa Toyo’oka
    • Organizer
      The 12th Changwon International Symposium on Advanced Science and Technology
    • Place of Presentation
      Changwon, Korea
    • Year and Date
      2014-10-29 – 2014-10-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 糖鎖転移酵素Endo-M-N175Qを用いた糖鎖高感度定量法の開発2014

    • Author(s)
      橋本立吾、閔俊哲、池田潔、井之上浩一、轟木堅一郎、豊岡利正
    • Organizer
      第27回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-08-20 – 2014-08-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sensitive analysis of diacetylpolyamines in human fingernail for early diagnosis of lung cancer2014

    • Author(s)
      Jun Zhe Min, Morota Yuka, Kenichiro Todoroki, Koichi Inoue, Toshimasa Toyo’oka
    • Organizer
      5th Asia Oceania Mass Spectrometry Conference
    • Place of Presentation
      Beijing, China
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 荷電構造を有するLC-ESI-MS/MS用N-結合型糖鎖誘導体化試薬の開発2014

    • Author(s)
      永井啓裕、閔俊哲、井之上浩一、轟木堅一郎、豊岡利正
    • Organizer
      第12回次世代を担う若手のためのフィジカル・ファーマフォーラム2014
    • Place of Presentation
      箱根
    • Year and Date
      2014-07-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト爪中低分子代謝物の高感度分析法の開発及び慢性疾患診断への応用

    • Author(s)
      閔俊哲
    • Organizer
      第59回 日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 癌の早期診断を指向したヒト爪中ジアセチルポリアミンの高感度分析

    • Author(s)
      閔俊哲、諸田有佳、轟木堅一郎、井之上浩一、豊岡利正
    • Organizer
      第26回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 荷電構造を有する糖鎖高感度誘導体化試薬の開発

    • Author(s)
      永井啓裕、閔 俊哲、轟木堅一郎、井之上浩一、豊岡利正
    • Organizer
      第26回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 光学活性アミン・アミノ酸を標的とした L-Pyroglutamic acid 活性エステル型キラル誘導体化試薬の開発

    • Author(s)
      望月俊樹、閔 俊哲、井之上浩一、轟木堅一郎、豊岡利正
    • Organizer
      第26回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] N-結合型糖鎖高感度分析を指向とした荷電構造を有する誘導体化試薬の開発

    • Author(s)
      永井啓裕、閔 俊哲、轟木堅一郎、井之上浩一、豊岡利正
    • Organizer
      第11回次世代を担う若手のためのフィジカル・ファーマフィーラム2013
    • Place of Presentation
      静岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 肺癌患者爪中ジアセチルポリアミンの高感度分析法の開発

    • Author(s)
      閔 俊哲、諸田有佳、轟木堅一郎、井之上浩一、豊岡利正
    • Organizer
      第38回日本医用マススペクトル学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] 生体微量成分の高感度分離分析法の開発と慢性疾患診断への展開

    • Author(s)
      閔 俊哲
    • Organizer
      第24回クロマトグラフィー科学会議
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] N-結合型糖鎖高感度分析を指向とした荷電構造を有するLC-ESI-MS/MS用誘導体化試薬の開発

    • Author(s)
      永井啓裕、閔 俊哲、轟木堅一郎、井之上浩一、豊岡利正
    • Organizer
      第24回クロマトグラフィー科学会議
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 光学活性カルボキシル化合物のLC-MS/MS分析用光学活性誘導体化試薬の開発および生体試料への応用

    • Author(s)
      高山卓大、桑原朋大、閔 俊哲、井之上浩一、轟木堅一郎、豊岡利正
    • Organizer
      第24回クロマトグラフィー科学会議
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病患者毛髪中アセチルアミノ酸の定量分析

    • Author(s)
      閔 俊哲、諸富貴史、冨安優樹、轟木堅一郎、井之上浩一、豊岡利正
    • Organizer
      新アミノ酸分析研究会 第3回学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 爪からのアミノ酸光学異性体の抽出方法2013

    • Inventor(s)
      閔 俊哲、豊岡利正
    • Industrial Property Rights Holder
      閔 俊哲、豊岡利正
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-094556
    • Filing Date
      2013-04-26
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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