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Effects of the diet on tumor growth in diabetic mice inoculated with cancer cells

Research Project

Project/Area Number 25560061
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionMusashino University

Principal Investigator

KOHAMA Tomoko  武蔵野大学, 薬学研究所, 客員研究員 (00364703)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Takashi  高崎健康福祉大学, 薬学部, 教授 (00326852)
KAWAHARADA Ritsuko  高崎健康福祉大学, 健康福祉学部, 助教 (60383147)
TAKANO-OHMURO Hiromi  武蔵野大学, 薬学研究所, 教授 (00124470)
KOHAMA Kazuhiro  武蔵野大学, 薬学研究所, 客員教授 (30101116)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords糖尿病 / 担がん / n-3系不飽和脂肪酸 / 宿主免疫系 / がん
Outline of Final Research Achievements

In recent years, diabetes mellitus (DM) has been shown to be associated with a high cancer risk. We investigated whether the intake of omega-3 fatty acid may promote cancer progression in DM concomitant with cancer-bearing conditions. DM-induced BALB/c mice were generated by the injection of STZ, and then they were inoculated subcutaneously with 5x104 Colon26 tumor cells (CT26DM mice). CT26DM mice were daily treated with ethyl icosapentate as omega-3 fatty acid (100 mg/body). The oral administration of EPA in those mice suppressed the tumor size but the number of immune cells (T, B and NK cells) in the spleen showed no difference compared to non-inoculated DM mice. Interestingly, the activity of NK cells significantly decreased in the spleens of CT26DM mice. It is necessary to consider that these patients be handled as immune compromised hosts due to their possibly lowered NK cell activity.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] 携帯型末梢神経検査装置PNS-7000により痛覚欠損が診断された2型糖尿病に1例2016

    • Author(s)
      小浜智子、佐伯晴美、野村房子、関根章司、永尾俊弘、篠崎哲也
    • Journal Title

      医学と薬学

      Volume: 73 Pages: 195-199

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 糖尿病母ラットのEPA摂取は新生仔心臓のシグナル異常を改善できるか?2015

    • Author(s)
      河原田律子、小浜智子、中村彰男
    • Journal Title

      糖尿病と妊娠

      Volume: 15 Pages: 122-126

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠尿糖尿病患者に対する新しい栄養指導法の検討2014

    • Author(s)
      大友崇, 河原田律子, 篠﨑 博光, 小浜 智子
    • Journal Title

      医学と薬学

      Volume: 71 Pages: 2331-2336

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 糖尿病ラットから生まれた仔の心臓におけるインスリンシグナルと魚油の影響2013

    • Author(s)
      河原田律子, 中村彰男, 小浜智子
    • Journal Title

      糖尿病と妊娠

      Volume: 13(1) Pages: 121-126

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A maternal diet rich in fish-oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats2013

    • Author(s)
      R Nasu-Kawaharada, A Nakamura, S Kakarla, E Blough, K Kohama, T Kohama
    • Journal Title

      Nutrition

      Volume: 29 Issue: 4 Pages: 688-692

    • DOI

      10.1016/j.nut.2012.11.017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 妊娠前女性における尿中ミオイノシトール測定による耐糖能以上の早期発見の試み2013

    • Author(s)
      小浜智子, 芳賀もえみ, 河原田律子
    • Journal Title

      医学と薬学

      Volume: 70(2) Pages: 323-330

    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病併発担がんマウスにおけるnー3系不飽和脂肪酸の宿主免疫系への影響2016

    • Author(s)
      中野貴史、吉田 文、原田 恩、河原田律子、小浜智子、大室弘美,小濱一弘、村上孝
    • Organizer
      第136回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜国際会議場(横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] In vivo 発行イメージングを用いた糖尿病状態におけるマウス1T1乳がん細胞の主要進展の特徴2015

    • Author(s)
      吉田 文、河原田律子、小浜智子,大室弘美、小濱一弘、村上孝
    • Organizer
      第10回日本分子イメージング学会
    • Place of Presentation
      タワーホールイベント会場(船堀)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Eicosapentaenoic acid may improve signaling pathway of the cardiac muscle infant2015

    • Author(s)
      Rituko Kawaharada,Sayo Ichikawa,Misa Muramoto,Akionakamura
    • Organizer
      12th Asian Congress of NUtrition
    • Place of Presentation
      パシフィコ横浜国際会議場(横浜)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo発光イメージングを用いた糖尿病状態におけるマウス4T1乳癌細胞の腫瘍進展の特徴2014

    • Author(s)
      吉田 文、原田 恩、斎藤克代、河原田律子、小浜智子、大室弘美、小濱一弘、村上 孝
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Book] 生物発光モデル動物作製によるがん生物学研究「27章がんの分子イメージング」2015

    • Author(s)
      村上孝
    • Total Pages
      7
    • Publisher
      科学同人
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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