Study of alginate's effect and mechanism, enhancing excretion and reducing absorption of strontium and cesium.
Project/Area Number |
25560062
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Takasaki University of Health and Welfare |
Principal Investigator |
Idota Yoko 高崎健康福祉大学, 薬学部, 研究員 (90629594)
|
Co-Investigator(Kenkyū-buntansha) |
YANO Kentaro 高崎健康福祉大学, 薬学部, 助手 (40644290)
OGIHARA Takuo 高崎健康福祉大学, 薬学部, 教授 (80448886)
ZHANG Pengyao 高崎健康福祉大学, 薬学部, 研究員 (80643311)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | アルギン酸 / イオン半径 / 価数 / 結合定数 / セシウム / 排泄促進 / 重金属 |
Outline of Final Research Achievements |
We have compared the effects of sodium alginate (Na-Alg) and calcium alginate (Ca-Alg) in promoting excretion and decreasing absorption of strontium (Sr) and cesium (Cs) in rats. Both additives increased the excretion of Sr, though concentration of Cs was significantly reduced only in the Ca-Alg group. We investigated the relationship between the physical parameters of various metal ions, and the binding affinity of these metal ions for alginate in vitro. In conclusion, our results indicate that the affinity of Alg for various metal ions is dependent upon their charge and ionic radius but not upon their ionization tendency. Our results are consistent with the idea that Alg would be effective as an excretion accelerator and/or absorption inhibitor for various toxic metal ions.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Cholesterol-Lowering Effect of Calcium Alginate in Rats2016
Author(s)
Idota Y, Kogure Y, Kato T, Ogawa M, Kobayashi S, Kakinuma C, Yano K, Arakawa H, Miyajima C, Kasahara F, Ogihara T
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 39
Issue: 1
Pages: 62-67
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors.2016
Author(s)
Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T.
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Journal Title
J Pharm Sci.
Volume: 105
Issue: 1
Pages: 339-342
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Cholesterol-lowering Effect of Calcium Alginate in Rats2016
Author(s)
Takuo OGIHARA, Yoko IDOTA, Yumi KOGURE, Takako KATO, Mana OGAWA, Shoko KOBAYASHI, Chihaya KAKINUMA, Kentaro YANO, Hiroshi ARAKAWA, Chihiro MIYAJIMA, Fumiyoshi KASAHARA
Organizer
日本農芸化学会2016年度大会
Place of Presentation
札幌市教育文化会館(北海道札幌市)
Year and Date
2016-03-27
Related Report
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[Presentation] アルギン酸による重金属吸着作用の解析2015
Author(s)
荻原琢男, 井戸田陽子, 加藤多佳子, 矢野健太郎, 荒川大, 安竹良礼, 宮島千尋, 笠原文善
Organizer
第42回日本毒性学会学術年会
Place of Presentation
石川県立音楽堂(石川県金沢市)
Year and Date
2015-06-29
Related Report
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[Presentation] Effects of Calcium Alginate on Lowering Cholesterol in Rats2014
Author(s)
T. Yasutake, Y. Idota, Y. Kogure, T. Kato, K. Yano, H. Arakawa, C. Kakinuma, C. Miyajima, F. Kasahara, S. Kobayashi, T. Ogihara
Organizer
第2回薬食国際カンファレンス
Place of Presentation
静岡
Year and Date
2014-11-05 – 2014-11-06
Related Report
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[Presentation] アルギン酸による血中コレステロール低下作用2014
Author(s)
安竹良礼, 井戸田陽子, 木暮悠美, 加藤多佳子, 矢野健太郎, 荒川 大, 柿沼千早, 宮島千尋, 笠原文善, 小林彰子, 荻原琢男
Organizer
第58回日本薬学会関東支部大会
Place of Presentation
東京
Year and Date
2014-10-04
Related Report
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