Control of elastic modulus on polymer scaffold by using three-dimensional micro-patterned substrate
| Project/Area Number |
25560186
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
SUNAMI Hiroshi 北海道大学, 先端生命科学研究科(研究院), 先端生命科学研究院研究員 (50374723)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 細胞バイオメカニクス / 細胞接着 / 細胞遊走 / 3Dマイクロパターン / 細胞足場 / バイオMEMS / 再生医工学 / 弾性率 / 弾性 / 医用高分子 / パターン基材 / 再生医療 / ソフトマテリアル |
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| Outline of Final Research Achievements |
First, I established the method how to paste homogeneously a thin polymer film on the three-dimensional micro-patterned substrate. In this method, a thin polymer film can be pasted on the pattern substrate without looseness or wrinkles of the film by using solubility of PVA in water. Next, I showed clearly difference in the elastic modulus of the thin film between on the convex and concave of the pattern. The NIH-3T3 cells were cultured on this film, it was observed that the cells gathered for the part of convex.
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Report
(2 results)
Research Products
(7 results)
