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Control of elastic modulus on polymer scaffold by using three-dimensional micro-patterned substrate

Research Project

Project/Area Number 25560186
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionHokkaido University

Principal Investigator

SUNAMI Hiroshi  北海道大学, 先端生命科学研究科(研究院), 先端生命科学研究院研究員 (50374723)

Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords細胞バイオメカニクス / 細胞接着 / 細胞遊走 / 3Dマイクロパターン / 細胞足場 / バイオMEMS / 再生医工学 / 弾性率 / 弾性 / 医用高分子 / パターン基材 / 再生医療 / ソフトマテリアル
Outline of Final Research Achievements

First, I established the method how to paste homogeneously a thin polymer film on the three-dimensional micro-patterned substrate. In this method, a thin polymer film can be pasted on the pattern substrate without looseness or wrinkles of the film by using solubility of PVA in water. Next, I showed clearly difference in the elastic modulus of the thin film between on the convex and concave of the pattern. The NIH-3T3 cells were cultured on this film, it was observed that the cells gathered for the part of convex.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (7 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Influence of the pattern size of micropatterned scaffolds on cell morphology, proliferation, migration and F-actin expression2014

    • Author(s)
      H. Sunami, I. Yokota, Y. Igarashi
    • Journal Title

      Biomaterials Science

      Volume: 2 (3) Pages: 399-409

    • NAID

      120005593423

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of the angles migrating cells turn on three-dimensional micro-patterned scaffolds by live cell imaging with an inverted microscope2014

    • Author(s)
      H. Sunami, I. Yokota, Y. Igarashi
    • Journal Title

      e-Journal of Surface Science and Nanotechnology

      Volume: in press

    • NAID

      130004438891

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 材料物性によって変化する細胞機能の最前線

    • Author(s)
      角南 寛
    • Organizer
      第3回ナノシステム若手交流会
    • Place of Presentation
      兵庫県大姫路工学キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 三次元パターンを利用した新規細胞走性の開発

    • Author(s)
      角南 寛
    • Organizer
      プロセスインテグレーションによる次世代ナノシステムの創製
    • Place of Presentation
      コクヨホール(品川)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Influence of the pattern size of three-dimensional micropatterned scaffolds on cell functions

    • Author(s)
      H. Sunami, I. Yokota, Y. Igarashi
    • Organizer
      7th International Symposium on Nanomedicine(ISNM2013)
    • Place of Presentation
      Kyushu Institute of Technology (Kitakyushu)
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 動物細胞の運動方向の制御基材、当該基材を用いた細胞の識別方法及び細胞の分離方法2013

    • Inventor(s)
      角南 寛, 横田 育子
    • Industrial Property Rights Holder
      角南 寛, 横田 育子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-229898
    • Filing Date
      2013-11-08
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 三次元形状を用いた動物細胞用構造体、動物細胞の分離方法及び動物細胞用構造体表面の弾性調節方法2013

    • Inventor(s)
      角南 寛, 横田 育子
    • Industrial Property Rights Holder
      角南 寛, 横田 育子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-261677
    • Filing Date
      2013-12-18
    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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