| Project/Area Number |
25560192
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
CHUNG Ung-il 東京大学, 工学(系)研究科(研究院), 教授 (30345053)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOHATA Nobuyuki 立命館大学, 生命科学部, 助教 (30419709)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 人工呼吸関連肺炎 / 可塑剤溶出抑制 |
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| Outline of Final Research Achievements |
In this study, we aimed to suppress ventilator-associated pneumonia by coating commercial intubation tubes with MPC, which is a biocompatible polymer. We investigated a coating efficiency and a suppressive effect on elution, and decided an appropriate coating condition.
We also found that DEHP (Di-(ethylhexyl)phthalate), the most famous plasticizer used in medical plastics, induced pro-inflammatory response in a dose dependent manner. It means that the coating with MPC can reduce plasticizers-possessing toxicity in clinical use.
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