| Project/Area Number |
25560194
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Masaya 京都大学, 再生医科学研究所, 准教授 (10332735)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マクロファージ / 細胞機能 / ピオグリタゾン / 徐放化 / ハイドロゲル |
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| Outline of Final Research Achievements |
Macrophages (Mφ) play an important role in the biological switching between chronic inflammation and tissue repair healing. Local release of pioglitazone enhanced the ratio of healing Mφ(M2) to inflammatory Mφ(M1), resulting a promoted healing process. Mφ were prepared through the interleukins stimulation of mouse bone marrow cells. When Mφ were incubated with hydrogels of pioglitazone release, the secretion of arginaseⅠas a marker of M2 macrophages enhanced. After applied into the skin defect of diabetic mice, the hydrogels of pioglitazone release enhanced the M2/M1 ratio at the defect and promoted the wound healing of skin.
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