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Electric device which interfaces heart to regenerated cardiac tissue derived from iPS cells

Research Project

Project/Area Number 25560197
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionOsaka University

Principal Investigator

YAGI Tetsuya  大阪大学, 工学(系)研究科(研究院), 教授 (50183976)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords再生医療 / 組織培養 / iPS細胞 / 電子デバイス / インターフェイス / 神経 / 筋 / 培養心筋細胞 / 神経組織 / 電気刺激 / 集積電子回路 / 神経インターフェイス / 再生医学 / 培養細胞 / 電流刺激 / 集積回路 / フィードバック刺激 / 培養組織 / 心筋細胞 / ペースメーカー / 医用電子デバイス
Outline of Final Research Achievements

To reconstruct the function of disordered excitable organs with implantation of cultured tissues, an electrical device is needed to interface the activities of the host organ to the implanted tissue. We have developed a multi-channel programmable integrated system that can electrically stimulate the tissue during the culture. The system can deliver currents at a high precision and with various spatio-temporal patterns to effectively control the activity of the cultured tissue. The system is compact and can be installed to a microscope, which allows a long term experiment duirng the culture.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Population response propagation to extrastriate areas evoked by intracortical electrical stimulation in V12016

    • Author(s)
      T.D. Fehervari, T. Yagi
    • Journal Title

      Frontiers in Neural Circuits

      Volume: VOL. 10 Pages: 1-14

    • DOI

      10.3389/fncir.2016.00006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Voltage-sensitive dye imaging of the visual cortices responding to electrical pulses at different intervals in mice in vivo.2014

    • Author(s)
      Hayashida Y, Takeuchi K, Ishikawa N, Okazaki Y, Tamas F, Tanaka H, Yagi T.
    • Journal Title

      Conference Proceedings of IEEE Engineering in Medicine and Biology Society

      Volume: n.a. Pages: 402-405

    • DOI

      10.1109/embc.2014.6943613

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A multichannel current stimulator chip for spatiotemporal pattern stimulation of neural tissues.2014

    • Author(s)
      Kameda S, Hayashida Y, Tanaka Y, Akita D, Yagi T.
    • Journal Title

      Conference Proceedings of IEEE Engineering in Medicine and Biology Society

      Volume: n.a. Pages: 5011-5015

    • DOI

      10.1109/embc.2014.6944750

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Inter-hemispheric neural excitations of visual cortices in response to electrical microstimuli in mice in vivo2015

    • Author(s)
      S. Futami, T.D. Fehervari, T. Yagi, Y. Hayashida
    • Organizer
      IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano Conference Center (Milan, Italy)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cortical neural excitations in rats in vivo with using a prototype of awireless multi-channel microstimulation system2015

    • Author(s)
      Y. Hayashida, Y. Umehira, K. Takatani, S. Futami, S. Kameda, T. Kamata, A. Ullah. Khan, Y. Takeuchi, M. Imai,and T. Yagi
    • Organizer
      IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano Conference Center (Milan, Italy)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A large scale simulation of excitation propagation in layer 2/3 ofprimary and secondary visual cortices of mice2015

    • Author(s)
      S. Ohtsu, T. Nomura, S. Uno, K. Maeda, Y. Hayashida,and T. Yagi
    • Organizer
      IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano Conference Center (Milan, Italy)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 皮質内微小電気刺激に対する神経興奮範囲の膜電位イメージング2015

    • Author(s)
      田中雄太, 林田祐樹, 坂田侑弥, 八木哲也
    • Organizer
      MEとバイオサイバネティックス研究会
    • Place of Presentation
      玉川大学(東京都・町田市)
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 膜電位感受性色素を用いたマウス左右大脳皮質間における信号伝達のin-vivoイメージング2015

    • Author(s)
      二見成俊, 林田祐樹, 八木哲也
    • Organizer
      MEとバイオサイバネティックス研究会
    • Place of Presentation
      熊本大学(熊本県・熊本市)
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス大脳視覚野における多点電極刺激に対する時空間神経応答のin-vivoイメージング解析2015

    • Author(s)
      高谷光基, 林田祐樹, 竹内浩造, 山口俊平, 岡崎祐香, 八木哲也
    • Organizer
      MEとバイオサイバネティックス研究会
    • Place of Presentation
      熊本大学(熊本県・熊本市)
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Prototyping and Testing of a VLSI Chip for Spatiotemporal Pattern Stimulationin Visual Cortical Prostheses2014

    • Author(s)
      S. Kameda, Y. Hayashida, T. Yagi.
    • Organizer
      計測自動制御学会 Life Engineering Symposium 2014 (LE2014)
    • Place of Presentation
      金沢大学(石川県・金沢市)
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] A Multi-channel Stimulation System with Wireless Communication and Power Transmission for Visual Cortical Prostheses2014

    • Author(s)
      S. Kameda, T. Kamata, Y. Hayashida, M. Imai, Y. Takeushi, T. Yagi.
    • Organizer
      Neuroscience 2014 (第37回日本神経科学大会)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Voltage-sensitive dye imaging of the visual cortices responding to electrical pulses at different intervals in mice in vivo2014

    • Author(s)
      Y. Hayashida, K. Takeuchi, N. Ishikawa, Y. Okazaki, F. Tamas, H. Tanaka, T. Yagi.
    • Organizer
      Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
    • Place of Presentation
      Chicago (The United States of America)
    • Year and Date
      2014-08-26 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] A multichannel current stimulator chip for spatiotemporal pattern stimulationof neural tissues2014

    • Author(s)
      S. Kameda, Y. Hayashida, Y. Tanaka, D. Akita, T. Yagi.
    • Organizer
      Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
    • Place of Presentation
      Chicago (The United States of America)
    • Year and Date
      2014-08-26 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 皮質1次視覚野における水平信号伝播の生理学シミュレーション2014

    • Author(s)
      烏野翔太,津崎圭亮,林田祐樹,八木哲也
    • Organizer
      ニューロコンピューティング研究会
    • Place of Presentation
      町田
    • Related Report
      2013 Research-status Report
  • [Presentation] 多チャンネル電流パルス刺激チップの試作と評価2013

    • Author(s)
      亀田成司, 林田祐樹, 田中宏喜, 秋田大, 八木哲也
    • Organizer
      平成25年電気学会電子・情報・システム部門大会
    • Place of Presentation
      北見
    • Related Report
      2013 Research-status Report
  • [Presentation] A Multi-channel Current-Pulse Generator Chip used for High Impedance Stimulating Electrodes2013

    • Author(s)
      Seiji Kameda, Yuki Hayashida, Hiroki Tanaka, Dai Akita and Tetsuya Yagi
    • Organizer
      Proceedings of Life Engineering Symposium 201
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Research-status Report
  • [Presentation] A Multi-Channel Current Stimulator Chip Intended for a Visual Cortical Implant2013

    • Author(s)
      Seiji Kameda, Yuki Hayashida, Hiroki Tanaka, Dai Akita, Atsushi Iwata and Tetsuya Yagi
    • Organizer
      The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Osaka
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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