| Project/Area Number |
25560199
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Okayama University |
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Principal Investigator |
NARUSE Keiji 岡山大学, 医歯(薬)学総合研究科, 教授 (40252233)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | メカノバイオロジー / 機械刺激 / バイオマテリアル / ３次元培養 / 自己集合性ペプチドゲル / メカのバイオロジー |
|---|
| Outline of Final Research Achievements |
Our bodies are always exposed to mechanical stress, for example, knees are subjected to a load while walking. Such stimulation is deemed to play an important role on activation of cell functions. In this study, to clarify the relationship between the mechanical stimulation and the cell functions and to utilize the mechanism of such mechanical stimulations, we investigated cell response when the cells (chondrosarcoma cells) were cyclically stretched after culturing in a self-assembling peptide hydrogel. As a result, the decreased secretion of collagen and another protein was observed.
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