How can we predict arterial thrombosis?
| Project/Area Number |
25560205
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Yamshita Atsushi 宮崎大学, 医学部, 助教 (90372797)
|
|---|
| Research Collaborator |
Asada Yujiro
Iwakiri Takashi
Kuroiwa Yasuyoshi
Sato Shinya
Sugita Chihiro
Takahashi Misaki
Matsuura Yunosuke
Matsuda Shuntaro
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 動脈血栓症 / 動物モデル / コンピューターシミュレーション |
|---|
| Outline of Final Research Achievements |
We studied the basis of plaque rupture (plaque erosion) of atherosclerotic artery in a rabbit model by histological review and computational fluid dynamics for the better prediction of arterial thrombosis.
With incomplete ligation, plaque erosion was induced by disturbed blood flow. We found that the magnitudes of wall shear stress (WSS), turbulence kinetic energy (TKE) and blood pressure gradients (BPG) correlated significantly with the extent of plaque erosion. We also found that the values for WSS and TKE were significantly larger at sites with, compared to without, erosive injury. But there was no definite threshold value of WSS or TKE on plaque erosion. The residual endothelial cells adjacent to the erosive sites were partly immuno-reactive for anti-caspase3.
These findings suggest that plaque erosion is caused not only by simple physical destruction of luminal surface, but also by cellular response to the physical environments.
|
Report
(4 results)
Research Products
(4 results)
