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Development of the novel in vivo bio-imaging technique to visualize microcirculation of pancreatic islet and its application to elucidate the pathogenesis of diabetes

Research Project

Project/Area Number 25560215
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKawasaki Medical School

Principal Investigator

KASHIHARA Naoki  川崎医科大学, 医学部, 教授 (10233701)

Co-Investigator(Kenkyū-buntansha) SATOH Minoru  川崎医科大学, 医学部, 講師 (70449891)
Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsランゲルハンス島 / in vivo imaging法 / 内皮障害 / 微小血行動態 / インスリン分泌 / 耐糖能障害 / 酸化ストレス
Research Abstract

Pancreatic beta cell dysfunction and its progressive loss are the main causative mechanisms of diabetes. Deterioration of microcirculation of islet blood flow could be involved in this mechanism. We have successfully developed a novel technique by which we could visualize microcirculation of pancreatic islet. We hypothesized that angiotensin II directly regulates the pancreatic islet microcirculation and thereby regulates insulin secretion. Angiotensin II significantly induced blood vessel contraction in the islets in a dose-dependent manner. In contrast, the angiotensin type 1 receptor blocker induced vasodilation. Glucose-stimulated insulin secretion was decreased by angiotensin II infusion. These results show that angiotensin II is involved in the regulation of pancreatic islet microcirculation and insulin secretion.
We expect this novel technique could contribute to delineate the pathogenesis of diabetes and develop therapeutic strategy for diabetes.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (17 results)

All 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (12 results) Remarks (2 results)

  • [Journal Article] Angiotensin II Regulates Islet Microcirculation and Insulin Secretion in Mice.2014

    • Author(s)
      Ihoriya C, Satoh M, Kuwabara A, Sasaki T, Kashihara N.
    • Journal Title

      Microcirculation

      Volume: 21 Issue: 2 Pages: 112-23

    • DOI

      10.1111/micc.12094

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension promotes islet morphological changes with vascular injury on pre-diabetic status in SHRsp rats2014

    • Author(s)
      Satoh M, Nagasu H, Haruna Y, Ihoriya C, Kadoya H, Sasaki T, Kashihara N
    • Journal Title

      Clin Exp Hypertens

      Volume: 36(3) Pages: 159-64

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension promotes islet morphological changes with vascular injury on pre-diabetic status in SHRsp rats.2014

    • Author(s)
      Satoh M, Nagasu H, Haruna Y, Ihoriya C, Kadoya H, Sasaki T, Kashihara N.
    • Journal Title

      Clin Exp Hypertens.

      Volume: 36 Issue: 3 Pages: 159-64

    • DOI

      10.3109/10641963.2013.804539

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rosuvastatin Activates Transcription Factor Nrf2 through p21cip1 Expression and Prevents Albuminuria through Preservation of Glomerular Endothelial Integrity in AKITA Diabetic Mice2013

    • Author(s)
      Ihoriya C, Satoh M, Sasaki T, Kashihara N
    • Organizer
      ASN2013
    • Place of Presentation
      Georgia World Congress Center (Atlanta, USA)
    • Year and Date
      2013-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 高血圧モデル動物における膵組織障害とARBによる膵内微小血管保護作用・耐糖能改善効果の検討2013

    • Author(s)
      庵谷千恵子, 佐藤稔, 春名克祐, 角谷裕之, 板野精之, 藤本壮八, 駒井則夫, 佐々木環, 柏原直樹
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2013-10-24
    • Related Report
      2013 Final Research Report
  • [Presentation] ロスバスタチンはNrf2活性化を介して抗酸化能を増強し糖尿病性腎症の進展を抑制する2013

    • Author(s)
      庵谷千恵子, 佐藤稔, 板野精之, 角谷裕之, 城所研吾, 佐々木環, 柏原直樹
    • Organizer
      第28回日本糖尿病合併症学会
    • Place of Presentation
      旭川グランドホテル(旭川市)
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Rosuvastatin Maintain Glomerular Endothelial Surface layer Through Nrf2 Activation in Mouse Diabetic Nephropathy2013

    • Author(s)
      Ihoriya C, Satoh M, Itano S, Kadoya H, Nishi Y, Kidokoro K, Komai N, Sasaki T, Kashihara N
    • Organizer
      WCN2013
    • Place of Presentation
      Hong Kong Convention and Exhibirion Centre(Hong Kong)
    • Year and Date
      2013-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 内皮GTP-cyclohydrolase1機能維持は内皮機能改善を介し糖尿病性腎症の発症・進展を抑制する2013

    • Author(s)
      城所研吾, 佐藤稔, 駒井則夫, 矢田豊隆, 佐々木環, 柏原直樹
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本キャッスルホテル(熊本市)
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 高血圧による膵ラ氏島組織障害のメカニズムの解明とアンジオテンシンII受容体拮抗薬(ARB)による膵保護作用の検討2013

    • Author(s)
      角谷裕之, 佐藤稔, 春名克祐, 庵谷千恵子, 西佑子, 城所研吾, 駒井則夫, 佐々木環, 柏原直樹
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本キャッスルホテル(熊本市)
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] in vivo live imaging 技術を用いたアンジオテンシンIIによるマウス膵島微小血流及びインスリン分泌制御機構の解析2013

    • Author(s)
      庵谷千恵子, 佐藤稔, 桑原篤憲, 角谷裕之, 西佑子, 城所研吾, 駒井則夫, 佐々木環, 柏原直樹
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本キャッスルホテル(熊本市)
    • Year and Date
      2013-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 高血圧モデル動物における膵組織障害とARBによる膵内微小血管保護作用・耐糖能改善効果の検討

    • Author(s)
      庵谷千恵子、佐藤 稔、春名克祐、角谷裕之、板野精之、藤本壮八、駒井則夫、佐々木環、柏原直樹
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ロスバスタチンはNrf2活性化を介して抗酸化能を増強し糖尿病性腎症の進展を抑制する

    • Author(s)
      庵谷千恵子、佐藤 稔、板野精之、角谷裕之、城所研吾、佐々木環、柏原直樹
    • Organizer
      第28回日本糖尿病合併症学会
    • Place of Presentation
      旭川グランドホテル(旭川市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] in vivo live imaging技術を用いたアンジオテンシンIIによるマウス膵島微小血流及びインスリン分泌制御機構の解析

    • Author(s)
      庵谷千恵子、佐藤 稔、桑原篤憲、角谷裕之、西 佑子、城所研吾、駒井則夫、佐々木環、柏原直樹
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本キャッスルホテル(熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 内皮GTP-cyclohydrolase 1機能維持は内皮機能改善を介し糖尿病性腎症の発症・進展を抑制する

    • Author(s)
      城所研吾、佐藤 稔、駒井則夫、矢田豊隆、佐々木環、柏原直樹
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本キャッスルホテル(熊本市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高血圧による膵ラ氏島組織障害のメカニズムの解明とアンジオテンシンII受容体拮抗薬(ARB)による膵保護作用の検討

    • Author(s)
      角谷裕之、佐藤 稔、春名克祐、庵谷千恵子、西佑子、城所研吾、駒井則夫、佐々木環、柏原直樹
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本キャッスルホテル(熊本市)
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.kawasaki-jinzo.net/greeting

    • Related Report
      2013 Final Research Report
  • [Remarks] 川崎医科大学 腎臓・高血圧内科学

    • URL

      http://www.kawasaki-jinzo.net/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2016-11-25  

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