| Project/Area Number |
25560216
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
FUJITA Satoshi 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長 (00392655)
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| Research Collaborator |
HARA Yusuke 国立研究開発法人 産業技術総合研究所材料, 化学領域 機能化学研究部門 化学材料評価グループ, 主任研究員
IKUTA Kenjiro 三菱レイヨン株式会社, 横浜先端技術研究所 バイオデバイス研究グループ
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | セルマイクロアレイ / 遺伝子導入 / セルチップ / 細胞マイクロアレイ / 薬剤徐放 / ナノバイオシステム / 細胞マイクロチップ / マイクロアレイ |
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| Outline of Final Research Achievements |
We made a simple method for producing multiple copies of microarray chips for the controlled release of small molecules in a cell-based screening assay. The described method enables the production of multiple copies of the chip by using an easy, rapid, and inexpensive array fabrication without any specialized devices. Moreover, screening using a miniaturized platform such as the microarray chip minimizes the consumption of cells and chemicals. Both the biodegradable material and compound injected into each channel can be individually tuned for optimized performance. We envisage that this method will be useful for developing cell-based HTS of small chemical compounds to find drug candidates.
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