| Project/Area Number |
25560217
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TATSUMI EISUKE 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (00216996)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEWA YOSHIAKI 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (20332405)
TSUKIYA TOMONORI 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (00311449)
MIZUNO TOSHIHIDE 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40426515)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 流路調節 / 植込み式 / 連続流型 / 補助人工心臓 / 完全遮断 / 小型 / 植込式 / 逆流防止 / 安全性 / 離脱試験 / 心機能評価 |
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| Outline of Final Research Achievements |
In this study, we tried to develop an implantable flow path regulating device, which preventing backflow at irregular stop and enhancing safety in a weaning test by means of enabling to adjust the flow path of the bypass circuit until shut-off. We employed compact mechanism that demonstrated adequate performance of preventing backflow with left ventricular assist conditions in the water experiment, and promoted the design of the flow path regulating device. Evaluation of this flow path regulating function was conducted by using a heart failure model in an acute animal experiment. It was excluded that prevention of fatal reduction of blood pressure and circulation flow rate during irregular stop of a continuous flow left ventricular assist.
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