Preparation of the propulsion engine-loaded nanoparticle and evaluation of its tissue permeability

• Project/Area Number: 25560223
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: BABA Koichi 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (00436172)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ナノバイオ材料 / 点眼液 / ナノ粒子薬剤

Outline of Final Research Achievements

Generally, it is recognized that the ocular penetration rate of eye drops into ocular globe is comparably low. This is because several barrier functions exist in ocular globe. Furthermore, we considered that the only the passive diffusion energy after eye drop administration is not enough for drug penetration into ocular globe. In this study we tried to prepare drug nanoparticle eye drops which has propulsion engine inside nanoparticles.

Research Products

• [Journal Article] Preparation of 1,4-bis(4-methylstyryl)benzene nanocrystals by a wet process and evaluation of their optical properties (2014)
  • Author(s): Koichi Baba and Kohji Nishida
  • Journal Title: Nanoscale Research Letters Volume: 9 Issue: 1 Pages: 16-16
  • DOI: 10.1186/1556-276x-9-16
  • Peer Reviewed
• [Presentation] Introduction of drug nanocrystal technology - for the potential tool to treatment of neurodegenerative disorders (2015)
  • Author(s): Koichi Baba
  • Organizer: 14th ICGP & 19th JSNP Joint Congress
  • Place of Presentation: Tsukuba International Congress Center ,Tsukuba, Japan
  • Year and Date: 2015-10-04
  • Invited
• [Presentation] Preparation and evaluation of fluorometholone nanoparticle eye drops (2014)
  • Author(s): Koichi Baba, Noriyasu Hashida, Kohji Nishida
  • Organizer: 2014 the Association for Research in Vision and Ophthalmology Annual Meeting
  • Place of Presentation: Orange County Convention Center in Orlando, Florida, USA
  • Year and Date: 2014-05-08
• [Presentation] Nanoparticle eye drops demonstrate enhanced ocular penetration (2014)
  • Author(s): Koichi Baba
  • Organizer: 4th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems
  • Place of Presentation: Hilton San Antonio Airport, San Antonio, USA
  • Invited
• [Book] International Innovation, ISSUE 128, EAST TO WEST, ISSN 2054-6254 (2014)
  • Author(s): Koichi Baba
  • Total Pages: 3
  • Publisher: Research Media Ltd
• [Patent(Industrial Property Rights)] 薬剤ナノ粒子を分散した水分散液の製造法およびその利用 (2013)
  • Inventor(s): 馬場耕一, 西田幸二, 橋田徳康
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-04-23
  • Overseas