| Project/Area Number |
25560225
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyushu University |
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Principal Investigator |
MURATA Masaharu 九州大学, 学内共同利用施設等, 准教授 (30304744)
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| Co-Investigator(Kenkyū-buntansha) |
橋爪 誠 九州大学, 医学研究院, 教授 (90198664)
河野 喬仁 九州大学, 先端融合医療レドックスナビ研究拠点, 学術研究員 (90526831)
濱野 展人 九州大学, 先端医療イノベーションセンター, 学術研究員 (80708397)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIZUME Makoto 九州大学, 大学院・医学研究院, 教授 (90198664)
KAWANO Takahito 九州大学, 先端融合医療レドックスナビ, 特任助教 (90526831)
HAMANO Nobuhito 九州大学, 先端医療イノベーションセンター, 特任助教 (80708397)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | ナノ材料 / DDS / 分子イメージング / タンパク工学 |
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| Research Abstract |
Protein nanocages are self-organized complexes of oligomers whose three-dimensional architecture can been determined in detail. These structures possess nanoscale inner cavities into which a variety of molecules, including therapeutic or diagnostic agents, can be encapsulated. These properties yield these particles suitable for a new class of drug delivery carrier, or as a bioimaging reagent that might respond to biochemical signals in many different cellular processes. We report here the design, synthesis, and biological characterization of a Pancreatic cancer nanocage carrying small heat-shock protein. These nanoscale protein cages, with a targeting peptide on their surfaces, were prepared by genetic engineering techniques. iRGD-carrying nanocages showed lower cytotoxicity and significantly higher specificity for human pancreatic cancer cell lines than other cell lines in vitro.
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