Development of artificial peptides reversibly changing their secondary structures in response to reductive condition
| Project/Area Number |
25560226
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
OBA Makoto 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (20396716)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 機能性ペプチド / 非天然型アミノ酸 / 刺激応答性材料 |
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| Outline of Final Research Achievements |
I designed seven-membered ring amino acid with disulfide (SS) bond in the side chain and synthesized its-containing peptides. SS bond was cleaved in response to reductive condition, resulting in structural change from cyclic to acyclic side chain. Furthermore, structural change of side chain led to the change in peptide secondary structure of its-containing peptides. We expected that its change would be from helical structure to random structure, however, we could not find such unambiguous change.
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Report
(4 results)
Research Products
(8 results)
