| Project/Area Number |
25560228
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIKKAWA Yamato 東京薬科大学, 薬学部, 准教授 (20274227)
HOZUMI Kentaro 東京薬科大学, 薬学部, 講師 (10453804)
KATAGIRI Fumihiko 東京薬科大学, 薬学部, 助教 (60420642)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | バイオマテリアル / 細胞外マトリックス / 基底膜 / ラミニン / ペプチド / マトリックス / 細胞接着 / キトサン / インテグリン / シンデカン / スペーサー |
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| Outline of Final Research Achievements |
Sixty active peptides derived from laminin-111 were conjugated onto a chitosan matrix and examined their biological activity using fibroblasts and neuronal cells. Twenty-six peptide-chitosan matrices promoted biological activities and were categorized into five groups depending on their activities. The most active peptide-chitosan matrices were selected in each group as an essential peptide matrix. Additionally, the effect of spacer on the biological activity of each peptide-chitosan matrix was examined using various lengths of spacers. The spacer-optimization for each peptide is important for designing effective peptide-chitosan matrices. The mixed essential peptide-chitosan matrices with the optimized spacer are useful as a biomaterial for tissue engineering.
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