Photoacoustic molecular imaging of macrophage with metal nanoparticle

• Project/Area Number: 25560235
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Tohoku University
• Principal Investigator: SAIJO YOSHIFUMI 東北大学, 医工学研究科, 教授 (00292277)
• Co-Investigator(Kenkyū-buntansha): OGASAWARA Koetsu 東北大学, 加齢医学研究所, 教授 (30323603)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 光音響イメージング / レーザー / 超音波 / マクロファージ / 金属微粒子 / 金ナノロッド / 炎症 / 動脈硬化 / 光音響ｲﾒｰｼﾞﾝｸﾞ / ニッケル

Outline of Final Research Achievements

Acoustical-resolution and optical-resolution photoacoustic microscope system were developed. Photoacoustic properties of some metals was measured and macrophage phagocytosing gold nanorod was observed by the system. Photoacoustic imaging of macrophage with gold nanorod has a potential to be a biomarker of inflammation.

Research Products

• [Journal Article] Simultaneous evaluation of articular cartilage and subchondral bone from immobilized knee in rats by photoacoustic imaging system. (2015)
  • Author(s): Hagiwara Y, Izumi T, Yabe Y, Sato M, Sonofuchi K, Kanazawa K, Koide M, Saijo Y, Itoi E.
  • Journal Title: J Orthop Sci. Volume: 20 Issue: 2 Pages: 397-402
  • DOI: 10.1007/s00776-014-0692-2
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional Imaging of the Vasculature in Chicken Embryo by Combination of Ultrasonic and Photoacoustic Imaging (2013)
  • Author(s): Mika Sato, Takuya Izumi, Yoshifumi Saijo, Yuji Watanabe, Harukazu Nakamura
  • Journal Title: Proceeding of 2013 Joint UFFC, EFTF and PFM Symposium Volume: 1 Pages: 1532-1533
  • Peer Reviewed
• [Journal Article] Ultrasonic and photoacoustic imaging of knee joints in normal and osteoarthritis rats. (2013)
  • Author(s): Izumi T, Sato M, Yabe Y, Hagiwara Y, Saijo Y
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc. 2013 Volume: 1 Pages: 1116-1119
  • DOI: 10.1109/embc.2013.6609701
  • Peer Reviewed
• [Presentation] Photoacoustic micro imaging of gold nanorod phagocytosing macrophage (2015)
  • Author(s): Saijo Y
  • Organizer: Optics in Cardiology 2015
  • Place of Presentation: Rotterdam, The Netherlands
  • Year and Date: 2015-03-11 – 2015-03-13
• [Presentation] Characterization of a single cell with multiple ultrasound parameters (2014)
  • Author(s): aijo Y, Shikama J, Yoshida K, Nagaoka R, Arakawa M, Kobayashi K, O’Brien Jr W
  • Organizer: 9th International Conference on Ultrasonic Biomedical Microscanning
  • Place of Presentation: Edinburgh, United Kingdom
  • Year and Date: 2014-09-28 – 2014-10-01
• [Presentation] New insight into understanding clinical ultrasound images by acoustic microscopy findings. (2013)
  • Author(s): Saijo Y
  • Organizer: 32nd International Symposium on Acoustical Imaging, Singapore
  • Place of Presentation: Singapore, Singapore
  • Invited
• [Presentation] Multimodal ultrasound microscopy for biomedical imaging. (2013)
  • Author(s): Saijo Y
  • Organizer: 21st International Congress on Acoustics
  • Place of Presentation: Montreal, Canada
  • Invited
• [Presentation] Evaluation of biological tissues by high frequency ultrasound and photoacoustics. (2013)
  • Author(s): Saijo Y
  • Organizer: Laser Ultrasonics and Advanced Sensing (LU2013)
  • Place of Presentation: Yokohama, Japan
  • Invited
• [Remarks] 西條研究室
  • URL: http://www.ecei.tohoku.ac.jp/imaging/index.htm
• [Remarks] 西條研究室
  • URL: http://www.ecei.tohoku.ac.jp/imaging/