Physiological approach against stimulation efficiency decline of retinal prosthesis

• Project/Area Number: 25560259
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Osaka University
• Principal Investigator: MIYOSHI Tomomitsu 大阪大学, 医学系研究科, 助教 (70314309)
• Co-Investigator(Kenkyū-buntansha): 澤井 元 大阪大学, 医学系研究科, 准教授 (20202103)
• Co-Investigator(Renkei-kenkyūsha): KANDA Hiroyuki 大阪大学, 医学系研究科, 助教 (50570248)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: electrical stimulation / adaptation / retina / cortex / prosthesis / 人工感覚器 / 人工網膜 / 電気刺激 / 誘発反応

Outline of Final Research Achievements

Psychophysical adaptation will affect the effectiveness of Brain-Machine interface which send artificial sensory input to the brain. Here we tried to evaluate and manipulate the adaptation in suprachoroidal-transretinal stimulation-type retinal prosthesis with electrophysiological method. The decline of evoked response by repetitive retinal stimulation was able to be recorded in cat visual cortex with multichannel electro-corticogram. Simultaneous stimulation to other cortical area which we tested could not change the decline of evoked response. Strategy for preventing adaptation was shown to be more investigated.

Research Products

• [Journal Article] Multiplexed spatiotemporal communication model in artificial neural networks. (2014)
  • Author(s): Tamura, S., Nishitani, Y., Kamimura, T., Hosokawa, C., Miyoshi, T., Sawai, H., Mizuno-Matsumoyo, Y., CHen, Y-W.
  • Journal Title: Automation, Control and Intelligent Systems Volume: 1 Issue: 6 Pages: 121-130
  • DOI: 10.11648/j.acis.20130106.11
  • Peer Reviewed
• [Journal Article] Spatiotemporal receptive field structures in retinogeniculate connections of cat (2013)
  • Author(s): Suematsu N, Naito T, Miyoshi T , Sawai H, Sato H
  • Journal Title: Frontiers in Systems Neuroscience Volume: 7 Pages: 1-13
  • DOI: 10.3389/fnsys.2013.00103
  • Peer Reviewed / Open Access
• [Presentation] 人工網膜によるON細胞とOFF細胞の単一ユニット反応 (2017)
  • Author(s): 三好智満
  • Organizer: 第40回日本神経科学大会
  • Place of Presentation: 幕張メッセ（千葉県千葉市）
  • Year and Date: 2017-07-20
• [Presentation] 人工網膜による単一ユニット反応:ネコLGNのON細胞とOFF細胞の比較 (2017)
  • Author(s): 三好智満
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: 浜松アクトシティコングレスセンターほか（静岡県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] STS型人工網膜用電極アレイの単一ユニット活動による機能評価 (2016)
  • Author(s): 三好智満、神田寛行、森本壮、不二門尚
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌市
  • Year and Date: 2016-03-22
• [Presentation] ネコ網膜-外側膝状体-一次視覚野結合における受容野特性の類似性 (2015)
  • Author(s): 末松尚史、内藤智之、三好智満、澤井元、佐藤宏道
  • Organizer: 第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] ネコ外側膝状体-一次視覚野間結合における受容野特性の類似性 (2014)
  • Author(s): 末松尚史、内藤智之、三好智満、澤井元、佐藤宏道
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Mechanism of receptive field generation in early visual pathway: simultaneous recording of retinal ganglion cells and lateral geniculate cells. (2014)
  • Author(s): Miyoshi, T., Suematsu, N., Naito, T., Sawai, H., Sato, H.
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島