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Physiological approach against stimulation efficiency decline of retinal prosthesis

Research Project

Project/Area Number 25560259
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionOsaka University

Principal Investigator

MIYOSHI Tomomitsu  大阪大学, 医学系研究科, 助教 (70314309)

Co-Investigator(Kenkyū-buntansha) 澤井 元  大阪大学, 医学系研究科, 准教授 (20202103)
Co-Investigator(Renkei-kenkyūsha) KANDA Hiroyuki  大阪大学, 医学系研究科, 助教 (50570248)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordselectrical stimulation / adaptation / retina / cortex / prosthesis / 人工感覚器 / 人工網膜 / 電気刺激 / 誘発反応
Outline of Final Research Achievements

Psychophysical adaptation will affect the effectiveness of Brain-Machine interface which send artificial sensory input to the brain. Here we tried to evaluate and manipulate the adaptation in suprachoroidal-transretinal stimulation-type retinal prosthesis with electrophysiological method. The decline of evoked response by repetitive retinal stimulation was able to be recorded in cat visual cortex with multichannel electro-corticogram. Simultaneous stimulation to other cortical area which we tested could not change the decline of evoked response. Strategy for preventing adaptation was shown to be more investigated.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] Multiplexed spatiotemporal communication model in artificial neural networks.2014

    • Author(s)
      Tamura, S., Nishitani, Y., Kamimura, T., Hosokawa, C., Miyoshi, T., Sawai, H., Mizuno-Matsumoyo, Y., CHen, Y-W.
    • Journal Title

      Automation, Control and Intelligent Systems

      Volume: 1 Issue: 6 Pages: 121-130

    • DOI

      10.11648/j.acis.20130106.11

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal receptive field structures in retinogeniculate connections of cat2013

    • Author(s)
      Suematsu N, Naito T, Miyoshi T , Sawai H, Sato H
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 7 Pages: 1-13

    • DOI

      10.3389/fnsys.2013.00103

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 人工網膜によるON細胞とOFF細胞の単一ユニット反応2017

    • Author(s)
      三好智満
    • Organizer
      第40回日本神経科学大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2017-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 人工網膜による単一ユニット反応:ネコLGNのON細胞とOFF細胞の比較2017

    • Author(s)
      三好智満
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松アクトシティコングレスセンターほか(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] STS型人工網膜用電極アレイの単一ユニット活動による機能評価2016

    • Author(s)
      三好智満、神田寛行、森本壮、不二門尚
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] ネコ網膜-外側膝状体-一次視覚野結合における受容野特性の類似性2015

    • Author(s)
      末松尚史、内藤智之、三好智満、澤井元、佐藤宏道
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] ネコ外側膝状体-一次視覚野間結合における受容野特性の類似性2014

    • Author(s)
      末松尚史、内藤智之、三好智満、澤井元、佐藤宏道
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Mechanism of receptive field generation in early visual pathway: simultaneous recording of retinal ganglion cells and lateral geniculate cells.2014

    • Author(s)
      Miyoshi, T., Suematsu, N., Naito, T., Sawai, H., Sato, H.
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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