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The relationship between exercise load and promotion of recovery from muscle atrophy in mice

Research Project

Project/Area Number 25560274
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionAichi Medical College for Physical and Occupational Therapy

Principal Investigator

Nahoko KIMURA  愛知医療学院短期大学, その他部局等, 助教 (00544751)

Co-Investigator(Kenkyū-buntansha) ITOH Yuta  名古屋学院大学, リハビリテーション学部, 講師 (30454383)
KAWAKAMI Keisuke  大分大学, 福祉健康科学部, 教授 (60195047)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords理学療法学 / 細胞増殖・細胞死 / 筋肉生理学 / 理学療法 / リハビリテーション科学
Outline of Final Research Achievements

To clarify the relationship between strength of isometric contraction exercises and the facilitating recovery of atrophied muscles, We developed the equipment for quantitative isometric contraction of mice plantar-flexer muscles using electrical stimulation. As a result, the functional and histological effect from the muscle atrophy by applying exercise equal to or greater than a definite intensity level, rather than simply raising mice normally or applying low intensity exercise. The application of intense exercise caused muscle injury, decreased the maximal torque, and inhibited recovery of myofiber size. Therefore, exercise at an appropriate intensity to avoid injury appears to be effective to promote recovery from muscle atrophy. This model could contribute to further investigations of mechanisms of recovery from muscle atrophy via exercise load methods.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 2013 Other

All Presentation (5 results) (of which Int'l Joint Research: 1 results) Remarks (3 results)

  • [Presentation] マウス足関節底屈筋群の遠心性筋収縮による筋損傷モデルの開発2016

    • Author(s)
      伊東佑太 鈴木惇也 縣信秀 木村菜穂子 平野孝行 河上敬介
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] The effective intensity of exercise load for facilitating recovery from muscle atrophy in mice2015

    • Author(s)
      伊東佑太 縣信秀 木村菜穂子 宮津真寿美 平野孝行 早川公英 村上太郎 河上敬介
    • Organizer
      World Confederation for physical Therapy Congress 2015 (WCPT)
    • Place of Presentation
      Shingapore
    • Year and Date
      2015-05-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筋損傷を引き起こす強度の運動は筋萎縮からの回復促進効果を下げる2014

    • Author(s)
      伊東佑太,縣信秀,木村菜穂子,宮津真寿美,平野孝行,河上敬介
    • Organizer
      第1回日本基礎理学療法学会学術集会・日本基礎理学療法学会第4回学術大会 合同学会
    • Place of Presentation
      名古屋学院大学(名古屋キャンパス白鳥学舎)(愛知県・名古屋市)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] ISOMETRIC CONTRACTION BY ELECTRICAL STIMULATION FACILITATS RECOVERY FROM MUSCLE ATROPHY.2013

    • Author(s)
      Yuta Itoh, Kiyoshi Yoshioka, Nobuhide Agata, Masumi Inoue-Miyazu, Keisuke Kawakami
    • Organizer
      6th WCPT-AWP & 12th ACPT Congress 2013
    • Place of Presentation
      Nan Shan Education & Training Center, Taichung, Taiwan
    • Related Report
      2013 Research-status Report
  • [Presentation] マウスヒラメ筋の筋萎縮からの回復促進効果と筋収縮負荷量との関係.

    • Author(s)
      伊東佑太、吉岡潔志、森友洋、縣信秀、木村菜穂子、宮津真寿美、河上敬介
    • Organizer
      第3回日本基礎理学療法学会学術大会
    • Place of Presentation
      名古屋大学医学部保健学科
    • Related Report
      2013 Research-status Report
  • [Remarks] 愛知医療学院短期大学 リハビリテーション学科教員紹介/主な業績

    • URL

      http://www.yuai.ac.jp/staff/pdf/pt_kimura.pdf

    • Related Report
      2015 Annual Research Report
  • [Remarks] 愛知医療学院短期大学 リハビリテーション学科理学療法学専攻 教員紹介 主な業績

    • URL

      http://www.yuai.ac.jp/staff/pdf/pt_kimura.pdf

    • Related Report
      2014 Research-status Report
  • [Remarks] 愛知医療学院短期大学 リハビリテーション学科教員紹介/主な業績

    • URL

      http://www.yuai.ac.jp/intro/pdf_teacher/pt_kimura.pdf

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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