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Multi-dimensional evaluation of rehabilitation for stroke patients using analysis of motor controllers in the brain

Research Project

Project/Area Number 25560276
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

KAKEI Shinji  公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, プロジェクトリーダー (40224365)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords片麻痺 / 予測制御 / フィードバック制御 / 同時活性化 / 共同運動 / 脳病態空間 / 神経疾患 / 定量的評価 / 病態の見える化 / 脳卒中 / リハビリテーション / 運動指令
Outline of Final Research Achievements

In the present study, we sesearched for new quantitative parameters that are useful to evaluate rehabilitation for stroke patients. We found five parameters: 1) precision of the predictive controller, 2) precision of the feedback controller, 3) co-contraction of agonists and antagonists, 4) synkinesis of proximal muscle activities, 5) power of "microsteps" (i.e. high frequency (3-8Hz) noise during voluntary movements). These parameters are quite useful to visualize functional state of stroke patients for a long period.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (38 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 5 results) Presentation (27 results) (of which Invited: 10 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Consensus paper: Neuroimmune mechanisms of cerebellar ataxias2015

    • Author(s)
      Mitoma H, Adhikari K, Aeschlimann D, Chattopadhyay P, Hadjivassiliou M, Hampe CS, Honnorat J, Joubert B, Kakei S, Lee J, Manto M, Matsunaga A, Mizusawa H, Nanri K, Shanmugarajah P, Yoneda M, Yuki N
    • Journal Title

      Cerebellum

      Volume: 14 Pages: 301-310

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mossy fibers in the cerebellar hemisphere show activity during an instructed delay period2014

    • Author(s)
      Takahiro Ishikawa, Saeka Tomatsu, Yoshiaki Tsunoda, Donna S Hoffman, Shinji Kakei
    • Journal Title

      Neuroscience Research

      Volume: 87 Pages: 84-89

    • DOI

      10.1016/j.neures.2014.07.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Releasing dentate nucleus cells from Purkinje cell inhibition generates output from the cerebrocerebellum2014

    • Author(s)
      Takahiro Ishikawa, Saeka Tomatsu, Yoshiaki Tsunoda, Jongho Lee, Donna S Hoffman, Shinji Kakei
    • Journal Title

      PLoS ONE

      Volume: 9(10) Issue: 10 Pages: e108774-e108774

    • DOI

      10.1371/journal.pone.0108774

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional evaluation of motor commands based on a simple linear model in human wrist movements and its clinical application2014

    • Author(s)
      Lee J, Kakei S
    • Journal Title

      ISITC 2014 proceeding

      Volume: 3 Pages: 92-95

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 小脳の神経回路2014

    • Author(s)
      筧 慎治, 石川享宏
    • Journal Title

      理学療法ジャーナル

      Volume: 48(12) Pages: 1135-1143

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 小脳症状の解析 feedback and feedforward2014

    • Author(s)
      筧 慎治, 李 鍾昊
    • Journal Title

      Annual Review 神経 2014

      Volume: 2014 Pages: 11-17

    • Related Report
      2013 Research-status Report
  • [Journal Article] Quantitative evaluation of cerebellar ataxia based on pathological patterns of the muscle activities.2013

    • Author(s)
      Lee J, Kagamihara Y, Kakei S
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 2013 Pages: 902-908

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Muscle synergy control model-tuned EMG driven torque estimation system with a musculo-skeletal model.2013

    • Author(s)
      Min K, Shin D, Lee J, Kakei S
    • Journal Title

      Proc IEEE Eng Med Biol Soc

      Volume: 2013 Pages: 3471-3476

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 脊椎動物における筋シナジーの系統進化に見られる創発2015

    • Author(s)
      筧 慎治
    • Organizer
      第21回創発システム・シンポジウム
    • Place of Presentation
      諏訪東京理科大学セミナーハウス(長野県・茅野市)
    • Year and Date
      2015-05-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 視覚誘導性追跡運動における予測的成分とフィードバック的成分の分離と評 価ー健常者と小脳障害患者の比較2015

    • Author(s)
      筧 慎治
    • Organizer
      第1回身体性システム講演会「予測制御とフィードバック制御」
    • Place of Presentation
      同志社大学 京田辺キャンパス (京都府・京田辺市)
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 手首の動きから探る脳内の運動制御器の状態ー基礎と臨床応用2015

    • Author(s)
      筧 慎治
    • Organizer
      第6回神経科学・リハビリテーション・ロボット工学のシナジー効果に関する研究会
    • Place of Presentation
      九州工業大学(福岡県・北九州市)
    • Year and Date
      2015-01-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳内運動制御器の非侵襲的分析を利用した高齢者の転倒リスク早期発見・対応システムの開発2015

    • Author(s)
      筧 慎治
    • Organizer
      厚生労働科学研究費補助金 難治性疾患等克服研究事業「運動失調症の分子病態解明・治療法の開発に関する研究班」班会議
    • Place of Presentation
      JA共催カンファレンスホール(東京都・千代田区)
    • Year and Date
      2015-01-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大脳小脳における出力生成メカニズム2014

    • Author(s)
      石川享宏,筧 慎治
    • Organizer
      包括脳ネットワーク 冬のシンポジウム
    • Place of Presentation
      東京ガーデンパレス(東京都・文京区)
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Releasing dentate nucleus cells from Purkinje cell inhibition generates output from the cerebrocerebellum2014

    • Author(s)
      Ishikawa T, Tomatsu S, Hoffman DS, Kakei S
    • Organizer
      Vision, Memory, Thought –国際シンポジウム
    • Place of Presentation
      東京大学伊藤記念ホール(東京都・文京区)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mossy fibers in the cerebellar hemisphere show activity during an instructed delay period2014

    • Author(s)
      Ishikawa T, Tomatsu S, Hoffman DS, Kakei S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C. (アメリカ合衆国)
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Transmitting signals from premotor and primary somatosensory cortexes construct muscle-like coordinate representation in primary motor cortex2014

    • Author(s)
      Fujiwara Y, Yasuda W, Lee J, Ishikawa T, Kakei S, Izawa J
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D.C. (アメリカ合衆国)
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional evaluation of motor commands based on a simple linear model in human wrist movements and its clinical application2014

    • Author(s)
      Lee J, Kakei S
    • Organizer
      2014 International Symposium on Information Technology Convergence (ISITC 2014)
    • Place of Presentation
      Chonbuk (韓国)
    • Year and Date
      2014-10-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dissociation and evaluation of outputs from predictive and feedback controllers for tracking movements in normal subjects and patients with neurological disorders2014

    • Author(s)
      Kakei S
    • Organizer
      INCF Japan Node International Workshop, Admvances in Neuroinformatics 2014
    • Place of Presentation
      理化学研究所 BSI(埼玉県・和光市)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遅延運動課題における小脳半球部への苔状線維入力2014

    • Author(s)
      石川享宏,戸松彩花,筧 慎治
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Estimation of pulling directions of wrist prime movers on the wrist with a musculoskeletal model2014

    • Author(s)
      閔庚甫, 李鍾昊, 筧 慎治
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of motor symptoms of patients with Parkinson's disease in terms of three components of tracking movement of the wrist2014

    • Author(s)
      李鍾昊, 織茂智之, 筧 慎治
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 歯状核ニューロンのバースト活動は脱抑制によって形成される2014

    • Author(s)
      石川享宏,筧 慎治
    • Organizer
      第8回Motor Control研究会
    • Place of Presentation
      筑波大学(茨城県・つくばみらい市)
    • Year and Date
      2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 筋電図信号からの関節の総拮抗度の推定に関する研究2014

    • Author(s)
      閔庚甫, 李鍾昊, 筧 慎治
    • Organizer
      第8回Motor Control研究会
    • Place of Presentation
      筑波大学(茨城県・つくばみらい市)
    • Year and Date
      2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] パーキンソン病における運動症状と随意運動における運動制御器の定量的指標との関係2014

    • Author(s)
      筧 慎治,李 鍾昊,吾妻玲欧,高橋 真,坂本昌己,稲葉 彰,織茂智之
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場・福岡サンパレス・福岡国際センター (福岡県・福岡市)
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dissociation of predictive and feedback controllers and its application for evaluation of motor functions in cerebellar disorders2013

    • Author(s)
      Kakei S
    • Organizer
      The 2013 International Conferences on Active Media Technology / Brain and Health Informatics
    • Place of Presentation
      Maebashi, Gunma, Japan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 上肢運動における予測的制御障害とフィードバック制御障害の分離評価とその臨床応用2013

    • Author(s)
      筧 慎治
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県民文化ホール
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] パーキンソン病における随意運動中の微小ステップ状運動2013

    • Author(s)
      筧 慎治
    • Organizer
      第5回TMD PD研究会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 小脳の予測制御系とフィードバック制御系への関わり:小脳性運動失調の精密分析から2013

    • Author(s)
      筧 慎治
    • Organizer
      第7回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京王プラザホテル 東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 小脳の予測制御系とフィードバック制御系への関わり:小脳性運動障害の解析から2013

    • Author(s)
      筧 慎治
    • Organizer
      第20回新潟神経疾患研究会 新潟県医師会主催生涯教育講座
    • Place of Presentation
      新潟大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Movement-related activities of cerebellar nuclear cells support forward model hypothesis2013

    • Author(s)
      Ishikawa T, Tomatsu S, Tsunoda Y, Hoffman DS, Kakei S
    • Organizer
      Neuroscience 2013 (the Society’s 43rd annual meeting
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 定量的運動指令システムを用いた手首運動の評価~健常者における各年代での検討~2013

    • Author(s)
      霜田直卑, 児玉三彦, 李 鍾昊, 筧 慎治, 正門由久
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県民文化ホール
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of three components of tracking movement of the wrist joint and its application for analysis of neurological disorders2013

    • Author(s)
      Lee JH, Kagamihara Y, Okada Y, Kakei S
    • Organizer
      Neuro2013(the 36st Annual Meeting of the Japan Neuroscience Society)
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] Coordinate frames of movement-related activity of cerebellar nuclear cells.2013

    • Author(s)
      Ishikawa T, Kakei S
    • Organizer
      Neuro2013(the 36st Annual Meeting of the Japan Neuroscience Society)
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] Quantitative evaluation model of the muscle control policy with EMG signal2013

    • Author(s)
      Min K, Shin D, Lee JH, Kakei S
    • Organizer
      Neuro2013(the 36st Annual Meeting of the Japan Neuroscience Society)
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] パーキンソン病(PD)における随意運動中の微小ステップ状運動(microsteps)2013

    • Author(s)
      筧 慎治, 李鍾昊, 吾妻玲欧,高橋 真,坂本昌己,稲葉 彰,織茂智之
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] Method for identifying and evaluating parallel motor control function in the brain based on electromyogram signals2013

    • Inventor(s)
      Kakei S, Lee J, Kagamihara Y
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-06-20
    • Acquisition Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Quantitative motor function evaluation system2013

    • Inventor(s)
      Kakei S, Lee J, Kagamihara Y
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-25
    • Acquisition Date
      2014-07-29
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 運動機能解析システム及びそのシステムの作動方法2013

    • Inventor(s)
      筧 慎治,李 鍾昊
    • Industrial Property Rights Holder
      公益財団法人東京都医学総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-095173
    • Filing Date
      2013-04-30
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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