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A novel algorithm for NIRS-determined cerebral oxygenation that suppresses influence of change in skin blood flow in humans.

Research Project

Project/Area Number 25560299
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Developmental mechanisms and the body works
Research InstitutionToyo University

Principal Investigator

Shigehiko Ogoh  東洋大学, 理工学部, 教授 (80553841)

Co-Investigator(Kenkyū-buntansha) SATO Kohei  日本女子体育大学, 体育学部, 准教授 (00409278)
TANAKA Naoki  東洋大学, 理工学部, 教授 (10416943)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords近赤外線分光法 / 脳酸素化動態 / 皮膚血流量 / 脳血流 / 酸素化ヘモグロビン / 脱酸素化ヘモグロビン / 脳酸素動態 / 脳神経活動 / レーザードップラー / 筋赤外線分光法 / 浅側頭動脈
Outline of Final Research Achievements

Spatially resolved near-infrared spectroscopy (NIRS) is used widely to measurement of regional cerebral oxygenation, but the NIRS signal is influenced by changes in extra cranial blood flow. We estimated an accurate cerebral oxygenation during exercise and cognitive task using new algorithm which eliminates the influence of the extra cranial blood flow on the NIRS signals. Our findings suggest the possibility that the new algorithm excludes the influence of skin blood flow on the NIRS-determined O2Hb even during condition with increased cerebral oxygenation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Acknowledgement Compliant: 4 results) Presentation (12 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] University of Copenhagen(Denmark)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Ultrasound tagged near infrared spectroscopy does not detect hyperventilation-induced changes in cerebral blood flow in humans.2016

    • Author(s)
      A. Lund, N.H. Secher, A. Hirasawa, S. Ogoh, T. Hashimoto, H.W. Schytz, M. Ashina, H. Sorensen.
    • Journal Title

      The Scandinavian Journal of Clinical & Laboratory Investigation

      Volume: Feb; 76(1) Pages: 82-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Influence of skin blood flow and source-detector distance on near-infrared spectroscopy-determined cerebral oxygenation in humans.2015

    • Author(s)
      Ai Hirasawa, Shintaro Yanagisawa, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh.
    • Journal Title

      Clin Physiol Funct Imaging.

      Volume: May;35(3) Issue: 2 Pages: 237-44

    • DOI

      10.1007/s10877-015-9709-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Extra-cerebral oxygenation influence on near-infrared-spectroscopy-determined frontal lobe oxygenation in healthy volunteers: a comparison between INVOS-4100 and NIRO-200NX2015

    • Author(s)
      Henrik Sorensen, Peter Rasmussen, Christoph Siebenmann,Morten Zaar, Morten Hvidtfeldt, Shigehiko Ogoh, Kohei Sato,Matthias Kohl-Bareis, Niels H Secher, Carsten Lundby
    • Journal Title

      Clin Physiol Funct Imaging

      Volume: May;35(3) Issue: 3 Pages: 177-84

    • DOI

      10.1111/cpf.12142

    • Related Report
      2015 Annual Research Report 2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of skin blood flow and source-detector distance on near-infrared spectroscopy-determined cerebral oxygenation in humans2015

    • Author(s)
      Ai Hirasawa, Shintaro Yanagisawa, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh
    • Journal Title

      Clin Physiol Funct Imaging

      Volume: May;35(3) Issue: 3 Pages: 237-44

    • DOI

      10.1111/cpf.12156

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regional re-distribution of blood flow in the external and internal carotid arteries during acute hypotension.2014

    • Author(s)
      Shigehiko Ogoh, Romain Lericollais, Ai Hirasawa, Sadayoshi Sakai, Herve Normand and Damian M. Bailey
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: May 15;306(10)

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] External carotid artery flow maintains near infrared spectroscopy-determined frontal lobe oxygenation during ephedrine administration2014

    • Author(s)
      Henrik Sorensen, Peter Rasmussen, Kohei Sato, Simon Persson, Niels D. Olesen, Henning B. Nielsen, Niels V. Olsen, Shigehiko Ogoh, Niels H. Secher
    • Journal Title

      Br J Anaesth.

      Volume: Sep;113(3) Issue: 3 Pages: 452-8

    • DOI

      10.1093/bja/aet481

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by phenylephrine reflects reduced skin blood flow.2014

    • Author(s)
      Shigehiko Ogoh, Kohei Sato, Kazunobu Okazaki, Tadayoshi Miyamoto, Frederik Secher, Henrik Sorensen, Peter Rasmussen, Niels H Secher
    • Journal Title

      Anesth Analg.

      Volume: Apr;118(4) Issue: 4 Pages: 823-9

    • DOI

      10.1213/ane.0000000000000145

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] nfluence of skin blood flow and source-detector distance on near-infrared spectroscopy-determined cerebral oxygenation in humans.2014

    • Author(s)
      Ai Hirasawa, Shintaro Yanagisawa, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh.
    • Journal Title

      Clin Physiol Funct Imaging.

      Volume: In Press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regional re-distribution of blood flow in the external and internal carotid arteries during acute hypotension.2014

    • Author(s)
      Shigehiko Ogoh, Romain Lericollais, Ai Hirasawa, Sadayoshi Sakai, Herve Normand and Damian M. Bailey.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: In Press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] External carotid artery flow maintains near infrared spectroscopy-determined frontal lobe oxygenation during ephedrine administration.2014

    • Author(s)
      Henrik Sorensen, Peter Rasmussen, Kohei Sato, Simon Persson, Niels D. Olesen, Henning B. Nielsen, Niels V. Olsen, Shigehiko Ogoh, Niels H. Secher.
    • Journal Title

      British Journal of Anesthesia.

      Volume: In Press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Near-infrared spectroscopy determined oxy-hemoglobin concentration does not reflect intracranial cerebral oxygenation especially during dynamic heavy exercise.2013

    • Author(s)
      Ai Hirasawa, Kohei Sato, Anna Oue, Tomoko Sadamoto and Shigehiko Ogoh.
    • Journal Title

      Journal of Exercise Science

      Volume: Nov;113(11) Pages: 2841-8

    • NAID

      40020052764

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Skin blood flow influences cerebral oxygenation measured by near-infrared spectroscopy during dynamic exercise.2013

    • Author(s)
      Taiki Miyazawa, Masahiro Horiuchi, Hidehiko Komine, Jun Sugawara, Paul J Fadel, Shigehiko Ogoh.
    • Journal Title

      Eur J Appl Physiol.

      Volume: Nov;113(11) Issue: 11 Pages: 2841-8

    • DOI

      10.1007/s00421-013-2723-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Ultrasound tagged near infrared spectroscopy does not express carbon dioxide reactivity in humans.2015

    • Author(s)
      A. Lund, A. Hirasawa, S. Ogoh, T. Hashimoto, H.W. Schytz, M. Ashina, N.H. Secher, H. Sorensen.
    • Organizer
      33rd congress of the Scandianvian Society of Anaesthsiology and Intensive Care
    • Place of Presentation
      Reykjavik, Iceland
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of coffee intake on dynamic cerebral blood flow regulation.2015

    • Author(s)
      Ai Hirasawa, Kohei Sato, Shinnosuke Ono, Marina Yoneya, Tomoko Sadamoto, Shigehiko Ogoh.
    • Organizer
      American College of Medicine Science (ACSM).
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 皮膚血流量の影響を除去した頭蓋内酸素化動態同定法の開発2014

    • Author(s)
      平澤愛, 金子貴仁, 田中尚樹, 舟根司, 木口雅史, 小河繁彦
    • Organizer
      日本体力医学会
    • Place of Presentation
      長崎大学(長崎県)
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Research-status Report
  • [Presentation] レジスタンス運動に伴う昇圧応答に対する脳血管ストレス緩衝メカニズム2014

    • Author(s)
      平澤 愛,佐々木 寛幸,小野 慎之助,小河繁彦
    • Organizer
      運動生理学会
    • Place of Presentation
      川崎医療福祉大学(岡山県)
    • Year and Date
      2014-07-20 – 2014-07-21
    • Related Report
      2014 Research-status Report
  • [Presentation] A novel algorithm for NIRS-determined cerebral oxygenation that suppresses influence of change in skin blood flow in humans.2014

    • Author(s)
      Ai Hirasawa, Takahito Kaneko, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh
    • Organizer
      American College of Medicine Science (ACSM)
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-27 – 2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] A novel algorithm for NIRS-determined cerebral oxygenation that suppresses influence of change in skin blood flow in humans.

    • Author(s)
      Ai Hirasawa, Takahito Kaneko, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh
    • Organizer
      American College of Medicine Science
    • Place of Presentation
      Orlando, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 定量的な前額部皮膚血流量変化がNIRS信号に及ぼす影響.

    • Author(s)
      平澤 愛, 柳澤 慎太郎, 田中 尚樹, 舟根 司, 木口 雅史, 小河繁彦
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京、日本教育会館
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳機能計測信号と各種生体信号の関係解析から見たストレス負荷状態の評価.

    • Author(s)
      山崎享子,平澤愛,小河繁彦,舟根司,木口雅史,田中尚樹
    • Organizer
      生体医工学シンポジウム
    • Place of Presentation
      福岡、九州大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 定量的な皮膚血流変化がNIRS信号に及ぼす影響.

    • Author(s)
      平澤愛、金子貴仁、田中尚樹、小河繁彦
    • Organizer
      運動と循環研究会
    • Place of Presentation
      滋賀、立命館大学(草津キャンパス)
    • Related Report
      2013 Research-status Report
  • [Presentation] 生体信号の低周波揺らぎを用いたストレス状態の可視化の試み.

    • Author(s)
      山崎享子,平澤愛,小河繁彦,舟根司,木口雅史,田中尚樹
    • Organizer
      可視化情報シンポジウム2013
    • Place of Presentation
      東京、工学院大学
    • Related Report
      2013 Research-status Report
  • [Presentation] The Effect of Skin Blood Flow on Near-Infrared Spectroscopy (NIRS) Dertemined Cerebral Oxygeneation in Humans.

    • Author(s)
      A. Hirasawa, S. Yanagisawa, N. Tanaka, T. Funane, M. Kiguchi, N. H. Secher and S. Ogoh
    • Organizer
      American College of Medicine Science
    • Place of Presentation
      Indianapolis,USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Cutaneous blood flow influences near infrared spectroscopy evaluation of frontal lobe oxygenation by approximately 30%.

    • Author(s)
      Henrik Sorensen, Matthias Kohl-Bareis, Christoph Siebenmann, Morten Zaar, Morten Hvidtfeldt, Shigehiko Ogoh, Kohei Sato, Niels H. Secher, Carsten Lundby, Peter Rasmussen.
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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