A novel algorithm for NIRS-determined cerebral oxygenation that suppresses influence of change in skin blood flow in humans.

• Project/Area Number: 25560299
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Developmental mechanisms and the body works
• Research Institution: Toyo University
• Principal Investigator: Shigehiko Ogoh 東洋大学, 理工学部, 教授 (80553841)
• Co-Investigator(Kenkyū-buntansha): SATO Kohei 日本女子体育大学, 体育学部, 准教授 (00409278) ; TANAKA Naoki 東洋大学, 理工学部, 教授 (10416943)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 近赤外線分光法 / 脳酸素化動態 / 皮膚血流量 / 脳血流 / 酸素化ヘモグロビン / 脱酸素化ヘモグロビン / 脳酸素動態 / 脳神経活動 / レーザードップラー / 筋赤外線分光法 / 浅側頭動脈

Outline of Final Research Achievements

Spatially resolved near-infrared spectroscopy (NIRS) is used widely to measurement of regional cerebral oxygenation, but the NIRS signal is influenced by changes in extra cranial blood flow. We estimated an accurate cerebral oxygenation during exercise and cognitive task using new algorithm which eliminates the influence of the extra cranial blood flow on the NIRS signals. Our findings suggest the possibility that the new algorithm excludes the influence of skin blood flow on the NIRS-determined O2Hb even during condition with increased cerebral oxygenation.

Research Products

• [Int'l Joint Research] University of Copenhagen(Denmark)
• [Journal Article] Ultrasound tagged near infrared spectroscopy does not detect hyperventilation-induced changes in cerebral blood flow in humans. (2016)
  • Author(s): A. Lund, N.H. Secher, A. Hirasawa, S. Ogoh, T. Hashimoto, H.W. Schytz, M. Ashina, H. Sorensen.
  • Journal Title: The Scandinavian Journal of Clinical & Laboratory Investigation Volume: Feb; 76(1) Pages: 82-7
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Influence of skin blood flow and source-detector distance on near-infrared spectroscopy-determined cerebral oxygenation in humans. (2015)
  • Author(s): Ai Hirasawa, Shintaro Yanagisawa, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh.
  • Journal Title: Clin Physiol Funct Imaging. Volume: May;35(3) Issue: 2 Pages: 237-44
  • DOI: 10.1007/s10877-015-9709-4
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Extra-cerebral oxygenation influence on near-infrared-spectroscopy-determined frontal lobe oxygenation in healthy volunteers: a comparison between INVOS-4100 and NIRO-200NX (2015)
  • Author(s): Henrik Sorensen, Peter Rasmussen, Christoph Siebenmann,Morten Zaar, Morten Hvidtfeldt, Shigehiko Ogoh, Kohei Sato,Matthias Kohl-Bareis, Niels H Secher, Carsten Lundby
  • Journal Title: Clin Physiol Funct Imaging Volume: May;35(3) Issue: 3 Pages: 177-84
  • DOI: 10.1111/cpf.12142
  • Peer Reviewed
• [Journal Article] Influence of skin blood flow and source-detector distance on near-infrared spectroscopy-determined cerebral oxygenation in humans (2015)
  • Author(s): Ai Hirasawa, Shintaro Yanagisawa, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh
  • Journal Title: Clin Physiol Funct Imaging Volume: May;35(3) Issue: 3 Pages: 237-44
  • DOI: 10.1111/cpf.12156
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Regional re-distribution of blood flow in the external and internal carotid arteries during acute hypotension. (2014)
  • Author(s): Shigehiko Ogoh, Romain Lericollais, Ai Hirasawa, Sadayoshi Sakai, Herve Normand and Damian M. Bailey
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. Volume: May 15;306(10)
  • Peer Reviewed
• [Journal Article] External carotid artery flow maintains near infrared spectroscopy-determined frontal lobe oxygenation during ephedrine administration (2014)
  • Author(s): Henrik Sorensen, Peter Rasmussen, Kohei Sato, Simon Persson, Niels D. Olesen, Henning B. Nielsen, Niels V. Olsen, Shigehiko Ogoh, Niels H. Secher
  • Journal Title: Br J Anaesth. Volume: Sep;113(3) Issue: 3 Pages: 452-8
  • DOI: 10.1093/bja/aet481
  • Peer Reviewed
• [Journal Article] A decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by phenylephrine reflects reduced skin blood flow. (2014)
  • Author(s): Shigehiko Ogoh, Kohei Sato, Kazunobu Okazaki, Tadayoshi Miyamoto, Frederik Secher, Henrik Sorensen, Peter Rasmussen, Niels H Secher
  • Journal Title: Anesth Analg. Volume: Apr;118(4) Issue: 4 Pages: 823-9
  • DOI: 10.1213/ane.0000000000000145
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] nfluence of skin blood flow and source-detector distance on near-infrared spectroscopy-determined cerebral oxygenation in humans. (2014)
  • Author(s): Ai Hirasawa, Shintaro Yanagisawa, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh.
  • Journal Title: Clin Physiol Funct Imaging. Volume: In Press
  • Peer Reviewed
• [Journal Article] Regional re-distribution of blood flow in the external and internal carotid arteries during acute hypotension. (2014)
  • Author(s): Shigehiko Ogoh, Romain Lericollais, Ai Hirasawa, Sadayoshi Sakai, Herve Normand and Damian M. Bailey.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. Volume: In Press
  • Peer Reviewed
• [Journal Article] External carotid artery flow maintains near infrared spectroscopy-determined frontal lobe oxygenation during ephedrine administration. (2014)
  • Author(s): Henrik Sorensen, Peter Rasmussen, Kohei Sato, Simon Persson, Niels D. Olesen, Henning B. Nielsen, Niels V. Olsen, Shigehiko Ogoh, Niels H. Secher.
  • Journal Title: British Journal of Anesthesia. Volume: In Press
  • Peer Reviewed
• [Journal Article] Near-infrared spectroscopy determined oxy-hemoglobin concentration does not reflect intracranial cerebral oxygenation especially during dynamic heavy exercise. (2013)
  • Author(s): Ai Hirasawa, Kohei Sato, Anna Oue, Tomoko Sadamoto and Shigehiko Ogoh.
  • Journal Title: Journal of Exercise Science Volume: Nov;113(11) Pages: 2841-8
  • NAID: 40020052764
  • Peer Reviewed
• [Journal Article] Skin blood flow influences cerebral oxygenation measured by near-infrared spectroscopy during dynamic exercise. (2013)
  • Author(s): Taiki Miyazawa, Masahiro Horiuchi, Hidehiko Komine, Jun Sugawara, Paul J Fadel, Shigehiko Ogoh.
  • Journal Title: Eur J Appl Physiol. Volume: Nov;113(11) Issue: 11 Pages: 2841-8
  • DOI: 10.1007/s00421-013-2723-7
  • Peer Reviewed
• [Presentation] Ultrasound tagged near infrared spectroscopy does not express carbon dioxide reactivity in humans. (2015)
  • Author(s): A. Lund, A. Hirasawa, S. Ogoh, T. Hashimoto, H.W. Schytz, M. Ashina, N.H. Secher, H. Sorensen.
  • Organizer: 33rd congress of the Scandianvian Society of Anaesthsiology and Intensive Care
  • Place of Presentation: Reykjavik, Iceland
  • Year and Date: 2015-06-10
  • Int'l Joint Research
• [Presentation] Effect of coffee intake on dynamic cerebral blood flow regulation. (2015)
  • Author(s): Ai Hirasawa, Kohei Sato, Shinnosuke Ono, Marina Yoneya, Tomoko Sadamoto, Shigehiko Ogoh.
  • Organizer: American College of Medicine Science (ACSM).
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] 皮膚血流量の影響を除去した頭蓋内酸素化動態同定法の開発 (2014)
  • Author(s): 平澤愛, 金子貴仁, 田中尚樹, 舟根司, 木口雅史, 小河繁彦
  • Organizer: 日本体力医学会
  • Place of Presentation: 長崎大学（長崎県）
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] レジスタンス運動に伴う昇圧応答に対する脳血管ストレス緩衝メカニズム (2014)
  • Author(s): 平澤 愛，佐々木 寛幸，小野 慎之助，小河繁彦
  • Organizer: 運動生理学会
  • Place of Presentation: 川崎医療福祉大学（岡山県）
  • Year and Date: 2014-07-20 – 2014-07-21
• [Presentation] A novel algorithm for NIRS-determined cerebral oxygenation that suppresses influence of change in skin blood flow in humans. (2014)
  • Author(s): Ai Hirasawa, Takahito Kaneko, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh
  • Organizer: American College of Medicine Science (ACSM)
  • Place of Presentation: Orlando, USA
  • Year and Date: 2014-05-27 – 2014-05-31
• [Presentation] A novel algorithm for NIRS-determined cerebral oxygenation that suppresses influence of change in skin blood flow in humans.
  • Author(s): Ai Hirasawa, Takahito Kaneko, Naoki Tanaka, Tsukasa Funane, Masashi Kiguchi, Henrik Sorensen, Niels H. Secher, Shigehiko Ogoh
  • Organizer: American College of Medicine Science
  • Place of Presentation: Orlando, USA
• [Presentation] 定量的な前額部皮膚血流量変化がNIRS信号に及ぼす影響.
  • Author(s): 平澤 愛, 柳澤 慎太郎, 田中 尚樹, 舟根 司, 木口 雅史, 小河繁彦
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京、日本教育会館
• [Presentation] 脳機能計測信号と各種生体信号の関係解析から見たストレス負荷状態の評価.
  • Author(s): 山崎享子，平澤愛，小河繁彦，舟根司，木口雅史，田中尚樹
  • Organizer: 生体医工学シンポジウム
  • Place of Presentation: 福岡、九州大学
• [Presentation] 定量的な皮膚血流変化がＮＩＲＳ信号に及ぼす影響.
  • Author(s): 平澤愛、金子貴仁、田中尚樹、小河繁彦
  • Organizer: 運動と循環研究会
  • Place of Presentation: 滋賀、立命館大学（草津キャンパス）
• [Presentation] 生体信号の低周波揺らぎを用いたストレス状態の可視化の試み.
  • Author(s): 山崎享子，平澤愛，小河繁彦，舟根司，木口雅史，田中尚樹
  • Organizer: 可視化情報シンポジウム2013
  • Place of Presentation: 東京、工学院大学
• [Presentation] The Effect of Skin Blood Flow on Near-Infrared Spectroscopy (NIRS) Dertemined Cerebral Oxygeneation in Humans.
  • Author(s): A. Hirasawa, S. Yanagisawa, N. Tanaka, T. Funane, M. Kiguchi, N. H. Secher and S. Ogoh
  • Organizer: American College of Medicine Science
  • Place of Presentation: Indianapolis,USA
• [Presentation] Cutaneous blood flow influences near infrared spectroscopy evaluation of frontal lobe oxygenation by approximately 30%.
  • Author(s): Henrik Sorensen, Matthias Kohl-Bareis, Christoph Siebenmann, Morten Zaar, Morten Hvidtfeldt, Shigehiko Ogoh, Kohei Sato, Niels H. Secher, Carsten Lundby, Peter Rasmussen.
  • Organizer: Experimental Biology
  • Place of Presentation: Boston, USA