The role of brain glycogen in exercise endurance
Project/Area Number |
25560334
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Sports science
|
Research Institution | University of Tsukuba |
Principal Investigator |
SOYA Hideaki 筑波大学, 体育系, 教授 (50221346)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 運動持久性 / 脳グリコゲン / 脳内乳酸 / ATP / 長時間運動 / 持久性パフォーマンス / アストロサイト / 中枢疲労 / 糖代謝 |
Outline of Final Research Achievements |
Brain glycogen could be utilized during prolonged exhaustive exercise. However, the role of brain glycogen in exercise endurance is unclear. To address this issue, we examined the effect of inhibition of brain glycogenolysis on exercise endurance. Blockade of brain glycogenolysis and lactate transport during exercise decreased endurance capacity associated with brain ATP levels. Our results demonstrated that lactate from brain glycogen fuels the exercising brain to retain exercise endurance, providing a new understanding of brain energetics during exercise.
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Report
(3 results)
Research Products
(12 results)