Assessment of skeletal muscle function using membrane capacitance during aging
| Project/Area Number |
25560339
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Kyoto Gakuen University |
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Principal Investigator |
Kimura Misaka 京都学園大学, 健康医療学部, 教授 (90150573)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Yosuke 国立研究開発法人医薬基盤・健康・栄養研究所, 研究員 (60550118)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨格筋 / サルコペニア / 生体電気インピーダンス法 / 細胞膜 / 細胞内液 / 筋細胞膜の整理物理学的特性 / MF-BIS / 骨格筋量 / 筋細胞膜の生物物理学的特性 |
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| Outline of Final Research Achievements |
Sarcopenia, age-related loss of skeletal muscle mass, strength, and function, is associated with impaired mobility, increased risk of falls, fractures, metabolic dysfunction and mortality. Many sarcopenia consensus definitions include low appendicular lean mass measured by dual energy x-ray absorptiometry (DXA); however, the association of DXA-measured lean mass with function is weak. Segmental bioelectrical impedance spectroscopy (S-BIS) provides a superior assessment of age-related muscle mass decline that is highly correlated with muscle functional loss. S-BIS measures accounted for ~85% of the age-related decrease in appendicular muscle power compared to only ~49% for DXA measures, and correlated strongly with leg muscle power independent of age. S-BIS measures including characteristic frequency, membrane capacitance, and phase angle, identified a predictive model that explained ~79% of inter-individual variance of leg muscle power.
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Report
(4 results)
Research Products
(74 results)
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[Presentation] 軽費老人ホーム利用者における5年間の身体機能の変化2014
Author(s)
吉中康子, 渡邊裕也, 横山慶一, 三宅基子, 山田陽介, 吉田司、 山縣恵美、 桝本妙子,岡山寧子、 木村みさか
Organizer
第56回日本老年医学会学術集会
Place of Presentation
福岡市、福岡国際会議場
Year and Date
2014-06-12 – 2014-06-14
Related Report
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[Presentation] 地域在住自立高齢者の保健習慣と健康度との関連2014
Author(s)
桝本妙子, 山田陽介, 吉田司、三宅基子, 渡邊裕也, 横山慶一,山縣恵美、吉中康子, 岡山寧子、 木村みさか
Organizer
第56回日本老年医学会学術集会
Place of Presentation
福岡市、福岡国際会議場
Year and Date
2014-06-12 – 2014-06-14
Related Report
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[Presentation] 熱中症により救急搬送された高齢者の生活状況2014
Author(s)
岡山寧子、山田陽介, 山縣恵美、三宅基子, 渡邊裕也, 横山慶一, 吉田司、桝本妙子,吉中康子、木村みさか
Organizer
第56回日本老年医学会学術集会
Place of Presentation
福岡市、福岡国際会議場
Year and Date
2014-06-12 – 2014-06-14
Related Report
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[Presentation] 地域高齢者を対象とした体力科学的アプローチによる認知症とサルコペニア予防の縦断研究―福岡那珂川研究― 認知機能低下者への運動介入の効果2014
Author(s)
古瀬裕次郎, 池永昌弘, 森村和浩, 山田陽介, 武田典, 三好伸幸, 栗山緑,町田由紀子, 合馬慎二, 坪井義夫, 山田達夫, 木村みさか, 清永明, 田中宏, 桧垣靖樹, Nakagawa Study Group
Organizer
第16回 七隈アルツハイマー病・パーキンソン病研究会
Place of Presentation
福岡大学、福岡
Year and Date
2014-04-26
Related Report
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[Presentation] Estimation of thigh muscle cross-sectional area by single- and multi-frequency segmental bioelectrical impedance analysis in the elderly.
Author(s)
Yosuke Yamada, M Ikenaga, N Miyoshi, K Morimura, N Takeda, A Kiyonaga, M Kimura, Y Higaki, H Tanaka, for the Nakagawa Study
Organizer
1st Montreal International Symposium of Grapa, Muscle from Humans to Cells
Place of Presentation
Monteal, Quebec, Canada
Related Report
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