| Project/Area Number |
25560343
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OGASAWARA Riki 東京大学, 総合文化研究科, 助教 (10634602)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJITA Satoshi 立命館大学, スポーツ健康科学部, 教授 (80451863)
NAKAZATO Koichi 日本体育大学, 保健医療学部, 教授 (00307993)
SATO Koji 立命館大学, スポーツ健康科学部, 助教 (20584022)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 運動 / 骨格筋 / 細胞外マトリックス / マトリックスメタロプロテアーゼ / 細胞接着分子 / インテグリン / 筋肥大 / シグナル伝達 / 筋収縮 / メカニカルストレス / MMPs / レジスタンス運動 / タンパク質代謝 / mTOR |
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| Outline of Final Research Achievements |
The purpose of the study was to investigate the effect of resistance exercise and aging on extracellular matrix (ECM) related proteins. Resistance exercise activates MMP-2 and MMP-9 during initial phase of resistance training but this response is attenuated with continuation of resistance training in rats. Resistance training increased β1-integrin (cell adhesion molecule) expression but not the other ECM proteins. Increases in integrins (α7- and β1-integrin) and reduced MMPs activities were also observed in older men compared with young men. These results suggest that integrins and MMPs play important role in the exercise-induced muscle hypertrophy.
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