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The significance of lactate on improved brain function

Research Project

Project/Area Number 25560344
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionRitsumeikan University

Principal Investigator

Hashimoto Takeshi  立命館大学, スポーツ健康科学部, 准教授 (70511608)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords認知機能 / 運動 / 乳酸 / 実行機能 / 脳血流量 / 持久性運動 / 神経活動 / 高強度間欠的運動 / レジスタンス運動 / 認知症 / 神経細胞
Outline of Final Research Achievements

This study was designed to assess the relevance of lactate, which is an “exercise-induced physiological molecule”, on brain function such as cognitive function.
The treatment of lactate on the cultured neuron and animal with exercise training suggested the possibility that lactate might improve neuronal function. Furthermore, in the human study, we suggest that augmented lactate metabolism and neuronal activity may be important factors for exercise-induced improvement of cognitive function. These findings may provide insight into development of the effective ways of exercise training and/or nutritional support on cognitive function.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (28 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results,  Open Access: 3 results) Presentation (13 results) (of which Int'l Joint Research: 2 results) Book (3 results) Remarks (2 results)

  • [Int'l Joint Research] University of Copenhagen(Denmark)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Ultrasound tagged near infrared spectroscopy does not detect hyperventilation-induced reduction in cerebral blood flow2016

    • Author(s)
      Lund A, Secher NH, Hirasawa A, Ogoh S, Hashimoto T, Schytz HW, Ashina M, Sorensen H
    • Journal Title

      The Scandinavian Journal of Clinical & Laboratory Investigation

      Volume: 76 Issue: 1 Pages: 82-87

    • DOI

      10.3109/00365513.2015.1101485

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Greater impact of acute high-intensity interval exercise on post-exercise executive function compared to moderate-intensity continuous exercise2016

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, and Hashimoto T
    • Journal Title

      Physiology and Behavior

      Volume: 155 Pages: 224-230

    • DOI

      10.1016/j.physbeh.2015.12.021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Repeated high-intensity interval exercise shortens the positive effect on executive function during post-exercise recovery in healthy young males2016

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, Ogoh S, and Hashimoto T
    • Journal Title

      Physiology and Behavior

      Volume: 160 Pages: 26-34

    • DOI

      10.1016/j.physbeh.2016.03.029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of hyperventilation-induced decrease in cerebral blood flow on cognitive function in healthy students2014

    • Author(s)
      Tsukamoto H, Hashimoto T, Hirasawa A, Hasegawa H, Ogoh S
    • Journal Title

      Japanese Journal of Physiological Anthropology

      Volume: 19 Pages: 225-232

    • NAID

      110009878925

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of changes in cerebral blood flow on cognitive function during exercise2014

    • Author(s)
      Ogoh S, Tsukamoto H, Hirasawa A, Hasegawa H, Hirose N, Hashimoto T
    • Journal Title

      Physiological Reports

      Volume: 2 Issue: 9 Pages: e12163-e12163

    • DOI

      10.14814/phy2.12163

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modest hypoxia significantly reduces triglyceride content and lipid droplet size in 3T3-L1 adipocytes.2013

    • Author(s)
      Hashimoto T, Yokokawa T, Endo Y, Iwanaka N, Higashida K, and Taguchi S.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 440 Issue: 1 Pages: 43-49

    • DOI

      10.1016/j.bbrc.2013.09.034

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cyclic restrictedfeeding enhances lipid storage in 3 T3-L1 adipocytes2013

    • Author(s)
      Hashimoto T, Endo Y
    • Journal Title

      Lipids in Health andDisease

      Volume: 12 Issue: 1 Pages: 76-79

    • DOI

      10.1186/1476-511x-12-76

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exercise-inducible factors to activate lipolysis in adipocytes2013

    • Author(s)
      Hashimoto T, Sato K, Iemitsu M
    • Journal Title

      Journal of Applied Physiology

      Volume: 115 Issue: 2 Pages: 260-267

    • DOI

      10.1152/japplphysiol.00427.2013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interaction between myoglobin and mitochondria in rat skeletal muscle.2013

    • Author(s)
      Yamada T, Furuichi Y, Takakura H, Hashimoto T, Hanai Y, Jue T, Masuda K
    • Journal Title

      J Appl Physiol

      Volume: 114 Issue: 4 Pages: 490-497

    • DOI

      10.1152/japplphysiol.00789.2012

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 運動後認知機能亢進に及ぼす運動と音楽の併用効果の検討2015

    • Author(s)
      田中大智,菅 唯志,塚本敏人,武中沙葵,浜岡隆文,橋本健志,伊坂忠夫
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館、和歌山県・和歌山市
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動による乳酸産生量と実行機能亢進の関係性2015

    • Author(s)
      塚本敏人,菅唯志,武中沙葵,田中大智,伊坂忠夫,小河繁彦,橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館、和歌山県・和歌山市
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動後の実行機能亢進を持続させるための最適な運動実施時間の検討2015

    • Author(s)
      武中沙葵, 塚本敏人, 菅唯志,田中大智, 浜岡隆文, 伊坂忠夫, 橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館、和歌山県・和歌山市
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動前のココア飲料摂取が高次脳機能に与える影響2015

    • Author(s)
      塚本 敏人,菅 唯志,石橋 彩,武中 沙葵,後藤 一成,海老 久美子,伊坂 忠夫,橋本 健志
    • Organizer
      日本スポーツ栄養学会
    • Place of Presentation
      立命館大学、滋賀県・草津市
    • Year and Date
      2015-07-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Local resistance exercise improves cognitive executive function in a dose-dependent manner2015

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Takeuchi T, Tanaka D, Hamaoka T, Isaka T, and Hashimoto T.
    • Organizer
      Brain&Brain PET - ISCBFM
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2015-06-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of high-intensity interval exercise and moderate-intensity continuous exercise on executive function in post-exercise recovery2015

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, and Hashimoto T
    • Organizer
      20th European College of Sport Science
    • Place of Presentation
      Malmo, Sweden
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Re-assessment of mitochondrial biogenesis-related signaling pathways in neuron2014

    • Author(s)
      Yokokawa T, Morimura N, Mishina M, Tanaka H, Fujita T, Iwanaka N, Hayahi T, Hashimoto T
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of hyperventilation-induced decrease in cerebral blood flow on cognitive function in healthy students2014

    • Author(s)
      Tsukamoto H, Hashimoto T, Hirasawa A, Hasegawa H, Ogoh S
    • Organizer
      61th American College of Sport Medicine
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] L6 Lactate Exposure Promotes Mitochondrial Biogenesis in Primary Neuronal Culture

    • Author(s)
      Yokokawa T, Yamamoto N, Morimura N, Mishina M, Tanaka H, Hashimoto T
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Voluntary running exercise with new supplement increases muscle mass via follistatin activation

    • Author(s)
      Oishi Y, Hashimoto T
    • Organizer
      18th European College of Sport Science
    • Place of Presentation
      バルセロナ(スペイン)
    • Related Report
      2013 Research-status Report
  • [Presentation] Body composition of human limbs by using BIA and MRI

    • Author(s)
      Yoshikawa M, Kurihara T, Taguchi S, Yamauchi J, Hashimoto T
    • Organizer
      18th European College of Sport Science
    • Place of Presentation
      バルセロナ(スペイン)
    • Related Report
      2013 Research-status Report
  • [Presentation] Exercise-induced ATGL upregulation involves AMPK in skeletal muscle

    • Author(s)
      Higashida K, Higuchi M, Hashimoto T
    • Organizer
      18th European College of Sport Science
    • Place of Presentation
      バルセロナ(スペイン)
    • Related Report
      2013 Research-status Report
  • [Presentation] Lipid metabolism: Molecular regulation and integrated responses to exercise. “Lipid droplet remodeling and control of lipolysis”

    • Author(s)
      Hashimoto T
    • Organizer
      60th American College of Sport Medicine
    • Place of Presentation
      インディアナポリス(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Book] 運動による脂肪分解のメカニズムに関する最新情報2013

    • Author(s)
      橋本健志、家光素行
    • Total Pages
      2
    • Publisher
      JATI Express
    • Related Report
      2013 Research-status Report
  • [Book] 運動で効果的に脂肪を燃焼させる最新情報2013

    • Author(s)
      橋本健志、家光素行
    • Total Pages
      2
    • Publisher
      JATI Express
    • Related Report
      2013 Research-status Report
  • [Book] 運動による抗肥満効果の分子メカニズム2013

    • Author(s)
      橋本健志、家光素行
    • Total Pages
      2
    • Publisher
      JATI Express
    • Related Report
      2013 Research-status Report
  • [Remarks] 立命館大学スポーツ健康科学部ニュース一覧

    • URL

      http://www.ritsumei.ac.jp/shs/news/article.html/?id=216

    • Related Report
      2015 Annual Research Report
  • [Remarks] 立命館大学スポーツ健康科学部ニュース一覧

    • URL

      http://www.ritsumei.ac.jp/shs/news/article.html/?id=193

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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