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Development and application of a method for measuring the phosphorus compound concentration in human skeletal muscle by quantitative magnetic resonance spectroscopy

Research Project

Project/Area Number 25560346
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionNational Agency for the Advancement of Sports and Health

Principal Investigator

TAKAHASHI Hideyuki  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツ科学研究部, 副主任研究員 (00292540)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Kohei  日本スポーツ振興センター・国立スポーツ科学センター, メディカルセンター, 副主任研究員 (50292925)
OIWA Nao  日本スポーツ振興センター・国立スポーツ科学センター, スポーツ科学研究部, 研究員 (50443247)
ARIMITSU Takuma  日本スポーツ振興センター・国立スポーツ科学センター, スポーツ科学研究部, 契約研究員 (00616021)
Research Collaborator TAKIZAWA Osamu  シーメンス・ジャパン株式会社, リサーチ&コラボレーション部, 研究員
MARUYAMA Katsuya  シーメンス・ジャパン株式会社, リサーチ&コラボレーション部, 研究員
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords磁気共鳴分光法 / リン酸化合物 / 競技種目特性 / クレアチンリン酸 / アデノシン三リン酸 / 骨格筋
Outline of Final Research Achievements

The purpose of this study was to establish a method for measuring the phosphorus compound concentration in human skeletal muscle by localized phosphorus magnetic resonance spectroscopy (31P-MRS) and apply it to sports science. We verified the validity of localized 31P-MRS to quantify phosphorus compounds such as phosphocreatine, adenosine triphosphate, and inorganic phosphate through a basic experiment. Moreover, we demonstrated that phosphocreatine and adenosine triphosphate concentrations in sprinters were significantly higher and lower, respectively, than those in untrained subjects and endurance runners. Therefore, the present results suggest that it is possible to measure the phosphorus compound concentration in human skeletal muscle using the developed 31P-MRS method, and that the method will become a useful tool for sports science.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Presentation (3 results)

  • [Presentation] Quantitative 31P-MRS reveals different phosphorus compound contents in the muscle between trained and untrained subjects2015

    • Author(s)
      Hideyuki Takahashi, Takuya Osawa, Yasuhiro Suzuki, Kazushige Goto, Nobukazu Kasai, Katsuya Maruyama
    • Organizer
      62th Annual Meeting of American College of Sports Medicine
    • Place of Presentation
      San Diego、California、USA
    • Year and Date
      2015-05-26 – 2015-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] リン磁気共鳴分光法を用いた骨格筋リン酸化合物濃度の非侵襲的定量2014

    • Author(s)
      高橋英幸、有光琢磨、大澤拓也、大岩奈青、中嶋耕平、丸山克也
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎大学、長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Extended ISIS法を用いた31P-MRSによる骨格筋リン酸化合物の定量方法の検討2014

    • Author(s)
      高橋英幸、有光琢磨、大澤拓也、大岩奈青、中嶋耕平、丸山克也、瀧澤修
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      ホテルグランヴィア京都、京都
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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