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Neural mechanism of relaxation effect of acupuncture

Research Project

Project/Area Number 25560356
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionNihon University

Principal Investigator

SAKATANI Kaoru  日本大学, 工学部, 教授 (90244350)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
KeywordsNIRS / ストレス / リラクゼーション / 鍼灸 / 自律神経 / 前頭前野 / 補完代替医療 / 呼吸 / prefrontal cortex / acupuncture / stress / anxiety / relaxation / asymmetry / neuronal activity / 抑うつ / 近赤外分光法 / 脳機能 / 脳血流
Outline of Final Research Achievements

The acupuncture is one of the clinical techniques of the Traditional Chines Medicine that enable therapeutic intervention to a wide variety of diseases and health promotion; however, the mechanism of the treatment by acupuncture is not yet clear. Our study, therefore, evaluated the neural mechanisms of effects of acupuncture on cognitive function and mental stress responses using near-infrared spectroscopy. We revealed that the acupuncture modulates the activation pattern of the prefrontal cortex which plays important roles in cognitive function and stress responses. The present results may create a new field of research that combines neuroscience and traditional medicine, contribute to clinical medicine.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (49 results)

All 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 21 results,  Open Access: 4 results,  Acknowledgement Compliant: 10 results) Presentation (23 results) (of which Int'l Joint Research: 6 results,  Invited: 10 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] University of Bergamo(Italy)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Tsinghua University(China)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Could fNIRS Promote2016

    • Author(s)
      Adorni R, Gatti A, Brugnera A, Sakatani K, Compare A.
    • Journal Title

      Front Psychol.

      Volume: 30 Pages: 456-456

    • DOI

      10.3389/fpsyg.2016.00456

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationships Between Gum-Chewing and Stress.2016

    • Author(s)
      Konno M, Takeda T, Kawakami Y, Suzuki Y, Kawano Y, Nakajima K, Ozawa T,Ishigami K, Takemura N, Sakatani K.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 876 Pages: 343-349

    • DOI

      10.1007/978-1-4939-3023-4_43

    • ISBN
      9781493930227, 9781493930234
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions.2016

    • Author(s)
      Itoh Y, Hine K, Miura H, Uetake T, Nakano M, Takemura N, Sakatani K.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 876 Pages: 319-325

    • DOI

      10.1007/978-1-4939-3023-4_40

    • ISBN
      9781493930227, 9781493930234
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Influence of Pleasant and Unpleasant Auditory Stimuli on Cerebral Blood Flow and Physiological Changes in Normal Subjects.2016

    • Author(s)
      Takeda T, Konno M, Kawakami Y, Suzuki Y, Kawano Y, Nakajima K, Ozawa T,Ishigami K, Takemura N, Sakatani K.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 876 Pages: 303-309

    • DOI

      10.1007/978-1-4939-3023-4_38

    • ISBN
      9781493930227, 9781493930234
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Acupuncture on Anxiety Levels and Prefrontal Cortex Activity Measured by Near-Infrared Spectroscopy: A Pilot Study.2016

    • Author(s)
      Sakatani K, Fujii M, Takemura N, Hirayama T.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 876 Pages: 297-302

    • DOI

      10.1007/978-1-4939-3023-4_37

    • ISBN
      9781493930227, 9781493930234
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of Cosmetic Therapy on Cognitive Function in Elderly Women Evaluated by Time-Resolved Spectroscopy2016

    • Author(s)
      Machida A, Shirato M, Tanida M, Kanemaru C, Nagai S, Sakatani K.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 876 Pages: 289-295

    • DOI

      10.1007/978-1-4939-3023-4_36

    • ISBN
      9781493930227, 9781493930234
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State.2016

    • Author(s)
      Matsumoto T, Fuchita Y, Ichikawa K, Fukuda Y, Takemura N, Sakatani K.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 876 Pages: 281-287

    • DOI

      10.1007/978-1-4939-3023-4_35

    • ISBN
      9781493930227, 9781493930234
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of acupuncture on anxiety levels and prefrontal cortex activity measured by near-infrared spectroscopy2015

    • Author(s)
      Sakatani K, Fujii ., Takemura N, Hirayama T
    • Journal Title

      Adv Exp Med Biol.

      Volume: 813

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of antioxidant supplements, Pyrroloquinoline quinone disodium salt (BioPQQTM), on cognitive functions2015

    • Author(s)
      Itoh Y, Hine K, Miura T, Uetake T, Nakano M, Takemura N, Sakatani K
    • Journal Title

      Adv Exp Med Biol.

      Volume: 813

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of cosmetic therapy on cognitive function in elderly women evaluated by time-resolved spectroscopy study2015

    • Author(s)
      Machida A, Shirato M, Tanida M, Kanemaru C, Nagai S, Sakatani K
    • Journal Title

      Adv Exp Med Biol.

      Volume: 813

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State2015

    • Author(s)
      Matsumoto T, Fuchita Y, Ichikawa K, Fukuda Y, Takemura N Sakatani K
    • Journal Title

      Adv Exp Med Biol.

      Volume: 813

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Detection of ROSC in patients with cardiac arrest during chest compression using NIRS: A pilot study2015

    • Author(s)
      Yagi T, Nagao K, Kawamorita T, Soga T, Ishii M, Chiba N, Watanabe K, Tani S, Yoshino A, Hirayama A, Sakatani K
    • Journal Title

      Adv Exp Med Biol.

      Volume: 813

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Correlation between LIFG and autonomic activation during stressful tasks: a functional near-infrared spectroscopy (fNIRS) study.2014

    • Author(s)
      Shi J, Sakatani K, Okamoto M, Yamaguchi Y, Zuo HC.
    • Journal Title

      J Huazhong Univ Sci Technolog Med Sci.

      Volume: 34(5) Issue: 5 Pages: 663-671

    • DOI

      10.1007/s11596-014-1334-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Monitoring of filter patency during carotid artery stenting using near-infrared spectroscopy with high time-resolution.2014

    • Author(s)
      Igarashi T, Sakatani K, Shibuya T, Hirayama T, Yoshino A, Katayama Y.
    • Journal Title

      Adv Exp Med Biol.

      Volume: ;812 Pages: 325-331

    • DOI

      10.1007/978-1-4939-0620-8_43

    • ISBN
      9781493905836, 9781493906208
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bayesian Prediction of Anxiety Level in Aged People at Rest Using 2-Channel NIRS Data from Prefrontal Cortex2014

    • Author(s)
      Kaoru Sakatani
    • Journal Title

      Adv Exp Med Biol

      Volume: 812 Pages: 303-8

    • DOI

      10.1007/978-1-4939-0620-8_40

    • ISBN
      9781493905836, 9781493906208
    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ginkobiloba extract improves working memory performance in middle-aged women: role of asymmetry of prefrontal cortex activity during a working memory task2014

    • Author(s)
      Kaoru Sakatani
    • Journal Title

      Adv Exp Med Biol

      Volume: 812 Pages: 295-301

    • DOI

      10.1007/978-1-4939-0620-8_39

    • ISBN
      9781493905836, 9781493906208
    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asymmetrical changes in cerebral blood oxygenation induced by an active standing test in children with postural tachycardia syndrome2014

    • Author(s)
      Kamiyama Y, Fujita Y, Fuchigami T, Kamiyama H, Takahashi S, Sakatani K.
    • Journal Title

      Adv Exp Med Biol

      Volume: 812 Pages: 271-278

    • DOI

      10.1007/978-1-4939-0620-8_36

    • ISBN
      9781493905836, 9781493906208
    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Increase in Deoxy-hemoglobin Concentration During Neuronal Activation in Patients with Cerebral Ischemia: A Simulation Study with the Balloon Model2014

    • Author(s)
      Takemura N, Sakatani K, Yoshino A, Hirayama T, Katayama Y.
    • Journal Title

      Adv Exp Med Biol

      Volume: 812 Pages: 225-231

    • DOI

      10.1007/978-1-4939-0620-8_30

    • ISBN
      9781493905836, 9781493906208
    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between asymmetry of spontaneous oscillation of hemodynamic changes in the prefrontal cortex and anxiety levels: a near-infrared spectroscopy study2014

    • Author(s)
      Kaoru Sakatani
    • Journal Title

      J Biomed Opt

      Volume: 19(2) Issue: 2 Pages: 27005-27005

    • DOI

      10.1117/1.jbo.19.2.027005

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of enriched environment on hippocampal neuronal cell death and neurogenesis in rat global ischemia.2014

    • Author(s)
      Kato T, Eriguchi T, Fujiwara N, Murata Y, Yoshino A, Sakatani K, Katayama Y.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 812 Pages: 203-208

    • DOI

      10.1007/978-1-4939-0620-8_27

    • ISBN
      9781493905836, 9781493906208
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute stress exposure preceding transient global brain ischemia exacerbates the decrease in cortical remodeling potential in the rat retrosplenial cortex2014

    • Author(s)
      Kaoru Sakatani
    • Journal Title

      Neurosci Res

      Volume: 78 Pages: 65-71

    • DOI

      10.1016/j.neures.2013.10.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] アロマセラピーのストレス緩和作用の神経生理学的メカニズム2015

    • Author(s)
      酒谷 薫, 谷田正弘
    • Organizer
      第18回日本アロマセラピー学会学術総会
    • Place of Presentation
      ワークピア横浜
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 中国医学における脳と心とからだ2015

    • Author(s)
      酒谷 薫
    • Organizer
      日本歯科東洋医学会 第33回学術大会
    • Place of Presentation
      日本大学法学部10号館
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The role of the task in emotion evocation: a NIRS study2015

    • Author(s)
      A.Compare, A.Brugnera, R.Adorni, and K. Sakatani
    • Organizer
      The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
    • Place of Presentation
      Wuhan China
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Correlation between NIRS and EEG Signals during Mental Arithmetic Task Evaluated by Self-Organizing Map2015

    • Author(s)
      K Oyama, K Sakatani
    • Organizer
      The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
    • Place of Presentation
      Wuhan China
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of antioxidant supplements (BioPQQTM) on cerebral blood flow and oxygen metabolism in the prefrontal cortex2015

    • Author(s)
      Masahiko Nakano, Yuta Murayama, Lizhen Hu, Kazuto Ikemoto, Tatsuo Uetake, Kaoru Sakatani
    • Organizer
      The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
    • Place of Presentation
      Wuhan China
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients2015

    • Author(s)
      M. Moriya, C. Aoki, K. Sakatani
    • Organizer
      The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
    • Place of Presentation
      Wuhan China
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relation between prefrontal cortex activity and respiratory rate during mental stress tasks: a near-infrared spectroscopic study2015

    • Author(s)
      Yuta Murayama, Lizhen Hu, Kaoru Sakatani
    • Organizer
      The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
    • Place of Presentation
      Wuhan China
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BCI-based Concentration Exercise system for Training the Mind2015

    • Author(s)
      Kaoru Sakatani, Kazuki Yanagisawa and Hitoshi Tsunashima
    • Organizer
      第9回ICME複合医工学国際会議(CME 2015)
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢女性に対する化粧療法が情動と前頭前野に与える効果2015

    • Author(s)
      酒谷 薫
    • Organizer
      人工知能学会全国大会(第29回)
    • Place of Presentation
      公立函館未来大学
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] これからの医工連携事業:先端医療から先端介護へ2015

    • Author(s)
      酒谷 薫
    • Organizer
      第9回横浜ITクラスター交流会
    • Place of Presentation
      横浜情報文化センター
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] NIRSの臨床応用の現状と未来2014

    • Author(s)
      酒谷薫
    • Organizer
      日本オプトメカトロニクス協会講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脳外科領域におけるイメージングセンサーの現状と未来:CISGをつかった医療用イメージセンサー2014

    • Author(s)
      酒谷薫
    • Organizer
      第27回マイクロプロセス・ナノテクノロジー国際会議
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 高齢者の運動療法の認知機能に対する効果ー光学的脳機能計測法による認知機能評価-2014

    • Author(s)
      酒谷薫
    • Organizer
      第4回日本中医学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 抑うつ :鍼灸の作用機転2014

    • Author(s)
      酒谷薫
    • Organizer
      第15回日本早期認知症学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脳疾患に対するNIRSの臨床応用:過去、現在、未来2014

    • Author(s)
      酒谷薫
    • Organizer
      第17回日本光脳機能イメージング学会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Effects of acupuncture on anxiety levels and prefrontal cortex activity measured by near-infrared spectroscopy2014

    • Author(s)
      Sakatani K, Fujii ., Takemura N, Hirayama T
    • Organizer
      ISOTT 2014
    • Place of Presentation
      London
    • Year and Date
      2014-06-28 – 2014-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of antioxidant supplements, Pyrroloquinoline quinone disodium salt (BioPQQTM), on cognitive functions2014

    • Author(s)
      Itoh Y, Hine K, Miura T, Uetake T, Nakano M, Takemura N, Sakatani K
    • Organizer
      ISOTT 2014
    • Place of Presentation
      London
    • Year and Date
      2014-06-28 – 2014-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of cosmetic therapy on cognitive function in elderly women evaluated by time-resolved spectroscopy study2014

    • Author(s)
      Machida A, Shirato M, Tanida M, Kanemaru C, Nagai S, Sakatani K
    • Organizer
      ISOTT 2014
    • Place of Presentation
      London
    • Year and Date
      2014-06-28 – 2014-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State2014

    • Author(s)
      Matsumoto T, Fuchita Y, Ichikawa K, Fukuda Y, Takemura N Sakatani K
    • Organizer
      ISOTT 2014
    • Place of Presentation
      London
    • Year and Date
      2014-06-28 – 2014-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Detection of ROSC in patients with cardiac arrest during chest compression using NIRS: A pilot study2014

    • Author(s)
      Yagi T, Nagao K, Kawamorita T, Soga T, Ishii M, Chiba N, Watanabe K, Tani S, Yoshino A, Hirayama A, Sakatani K
    • Organizer
      ISOTT 2014
    • Place of Presentation
      London
    • Year and Date
      2014-06-28 – 2014-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Active agingを支援する高齢者の脳と心の健康増進2014

    • Author(s)
      酒谷薫
    • Organizer
      第53回日本生体医工学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 光学的生体計測法の臨床医学への応用2014

    • Author(s)
      酒谷薫
    • Organizer
      福島県立医科大学産学連携セミナー
    • Place of Presentation
      福島
    • Year and Date
      2014-05-22
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Effects of acupuncture on anxiety levels and prefrontal cortex activity measured by near infrared spectroscopy: a pilot study2014

    • Author(s)
      Sakatani K, Fujii M, Takemura N
    • Organizer
      42nd Meeting of the International Society on Oxygen Transport to Tissue
    • Place of Presentation
      London
    • Related Report
      2013 Research-status Report
  • [Remarks] 酒谷研究室

    • URL

      http://sakatani-lab.org/

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Patent(Industrial Property Rights)] 遠隔患者支援システム2016

    • Inventor(s)
      酒谷薫、他2名
    • Industrial Property Rights Holder
      日本大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-061513
    • Filing Date
      2016-03-25
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 光学的イメージング医療システムおよびカメラ2014

    • Inventor(s)
      酒谷薫
    • Industrial Property Rights Holder
      日本大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-04-16
    • Acquisition Date
      2015-11-16
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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