Neural mechanism of relaxation effect of acupuncture

• Project/Area Number: 25560356
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Nihon University
• Principal Investigator: SAKATANI Kaoru 日本大学, 工学部, 教授 (90244350)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: NIRS / ストレス / リラクゼーション / 鍼灸 / 自律神経 / 前頭前野 / 補完代替医療 / 呼吸 / prefrontal cortex / acupuncture / stress / anxiety / relaxation / asymmetry / neuronal activity / 抑うつ / 近赤外分光法 / 脳機能 / 脳血流

Outline of Final Research Achievements

The acupuncture is one of the clinical techniques of the Traditional Chines Medicine that enable therapeutic intervention to a wide variety of diseases and health promotion; however, the mechanism of the treatment by acupuncture is not yet clear. Our study, therefore, evaluated the neural mechanisms of effects of acupuncture on cognitive function and mental stress responses using near-infrared spectroscopy. We revealed that the acupuncture modulates the activation pattern of the prefrontal cortex which plays important roles in cognitive function and stress responses. The present results may create a new field of research that combines neuroscience and traditional medicine, contribute to clinical medicine.

Research Products

• [Int'l Joint Research] University of Bergamo(Italy)
• [Int'l Joint Research] Tsinghua University(China)
• [Journal Article] Could fNIRS Promote (2016)
  • Author(s): Adorni R, Gatti A, Brugnera A, Sakatani K, Compare A.
  • Journal Title: Front Psychol. Volume: 30 Pages: 456-456
  • DOI: 10.3389/fpsyg.2016.00456
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationships Between Gum-Chewing and Stress. (2016)
  • Author(s): Konno M, Takeda T, Kawakami Y, Suzuki Y, Kawano Y, Nakajima K, Ozawa T,Ishigami K, Takemura N, Sakatani K.
  • Journal Title: Adv Exp Med Biol. Volume: 876 Pages: 343-349
  • DOI: 10.1007/978-1-4939-3023-4_43
  • ISBN: 9781493930227, 9781493930234
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions. (2016)
  • Author(s): Itoh Y, Hine K, Miura H, Uetake T, Nakano M, Takemura N, Sakatani K.
  • Journal Title: Adv Exp Med Biol. Volume: 876 Pages: 319-325
  • DOI: 10.1007/978-1-4939-3023-4_40
  • ISBN: 9781493930227, 9781493930234
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influence of Pleasant and Unpleasant Auditory Stimuli on Cerebral Blood Flow and Physiological Changes in Normal Subjects. (2016)
  • Author(s): Takeda T, Konno M, Kawakami Y, Suzuki Y, Kawano Y, Nakajima K, Ozawa T,Ishigami K, Takemura N, Sakatani K.
  • Journal Title: Adv Exp Med Biol. Volume: 876 Pages: 303-309
  • DOI: 10.1007/978-1-4939-3023-4_38
  • ISBN: 9781493930227, 9781493930234
  • Peer Reviewed
• [Journal Article] Effects of Acupuncture on Anxiety Levels and Prefrontal Cortex Activity Measured by Near-Infrared Spectroscopy: A Pilot Study. (2016)
  • Author(s): Sakatani K, Fujii M, Takemura N, Hirayama T.
  • Journal Title: Adv Exp Med Biol. Volume: 876 Pages: 297-302
  • DOI: 10.1007/978-1-4939-3023-4_37
  • ISBN: 9781493930227, 9781493930234
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of Cosmetic Therapy on Cognitive Function in Elderly Women Evaluated by Time-Resolved Spectroscopy (2016)
  • Author(s): Machida A, Shirato M, Tanida M, Kanemaru C, Nagai S, Sakatani K.
  • Journal Title: Adv Exp Med Biol. Volume: 876 Pages: 289-295
  • DOI: 10.1007/978-1-4939-3023-4_36
  • ISBN: 9781493930227, 9781493930234
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State. (2016)
  • Author(s): Matsumoto T, Fuchita Y, Ichikawa K, Fukuda Y, Takemura N, Sakatani K.
  • Journal Title: Adv Exp Med Biol. Volume: 876 Pages: 281-287
  • DOI: 10.1007/978-1-4939-3023-4_35
  • ISBN: 9781493930227, 9781493930234
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of acupuncture on anxiety levels and prefrontal cortex activity measured by near-infrared spectroscopy (2015)
  • Author(s): Sakatani K, Fujii ., Takemura N, Hirayama T
  • Journal Title: Adv Exp Med Biol. Volume: 813
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of antioxidant supplements, Pyrroloquinoline quinone disodium salt (BioPQQTM), on cognitive functions (2015)
  • Author(s): Itoh Y, Hine K, Miura T, Uetake T, Nakano M, Takemura N, Sakatani K
  • Journal Title: Adv Exp Med Biol. Volume: 813
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of cosmetic therapy on cognitive function in elderly women evaluated by time-resolved spectroscopy study (2015)
  • Author(s): Machida A, Shirato M, Tanida M, Kanemaru C, Nagai S, Sakatani K
  • Journal Title: Adv Exp Med Biol. Volume: 813
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State (2015)
  • Author(s): Matsumoto T, Fuchita Y, Ichikawa K, Fukuda Y, Takemura N Sakatani K
  • Journal Title: Adv Exp Med Biol. Volume: 813
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Detection of ROSC in patients with cardiac arrest during chest compression using NIRS: A pilot study (2015)
  • Author(s): Yagi T, Nagao K, Kawamorita T, Soga T, Ishii M, Chiba N, Watanabe K, Tani S, Yoshino A, Hirayama A, Sakatani K
  • Journal Title: Adv Exp Med Biol. Volume: 813
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Correlation between LIFG and autonomic activation during stressful tasks: a functional near-infrared spectroscopy (fNIRS) study. (2014)
  • Author(s): Shi J, Sakatani K, Okamoto M, Yamaguchi Y, Zuo HC.
  • Journal Title: J Huazhong Univ Sci Technolog Med Sci. Volume: 34(5) Issue: 5 Pages: 663-671
  • DOI: 10.1007/s11596-014-1334-9
  • Peer Reviewed
• [Journal Article] Monitoring of filter patency during carotid artery stenting using near-infrared spectroscopy with high time-resolution. (2014)
  • Author(s): Igarashi T, Sakatani K, Shibuya T, Hirayama T, Yoshino A, Katayama Y.
  • Journal Title: Adv Exp Med Biol. Volume: ;812 Pages: 325-331
  • DOI: 10.1007/978-1-4939-0620-8_43
  • ISBN: 9781493905836, 9781493906208
  • Peer Reviewed
• [Journal Article] Bayesian Prediction of Anxiety Level in Aged People at Rest Using 2-Channel NIRS Data from Prefrontal Cortex (2014)
  • Author(s): Kaoru Sakatani
  • Journal Title: Adv Exp Med Biol Volume: 812 Pages: 303-8
  • DOI: 10.1007/978-1-4939-0620-8_40
  • ISBN: 9781493905836, 9781493906208
  • Peer Reviewed
• [Journal Article] Ginkobiloba extract improves working memory performance in middle-aged women: role of asymmetry of prefrontal cortex activity during a working memory task (2014)
  • Author(s): Kaoru Sakatani
  • Journal Title: Adv Exp Med Biol Volume: 812 Pages: 295-301
  • DOI: 10.1007/978-1-4939-0620-8_39
  • ISBN: 9781493905836, 9781493906208
  • Peer Reviewed
• [Journal Article] Asymmetrical changes in cerebral blood oxygenation induced by an active standing test in children with postural tachycardia syndrome (2014)
  • Author(s): Kamiyama Y, Fujita Y, Fuchigami T, Kamiyama H, Takahashi S, Sakatani K.
  • Journal Title: Adv Exp Med Biol Volume: 812 Pages: 271-278
  • DOI: 10.1007/978-1-4939-0620-8_36
  • ISBN: 9781493905836, 9781493906208
  • Peer Reviewed
• [Journal Article] Mechanism of Increase in Deoxy-hemoglobin Concentration During Neuronal Activation in Patients with Cerebral Ischemia: A Simulation Study with the Balloon Model (2014)
  • Author(s): Takemura N, Sakatani K, Yoshino A, Hirayama T, Katayama Y.
  • Journal Title: Adv Exp Med Biol Volume: 812 Pages: 225-231
  • DOI: 10.1007/978-1-4939-0620-8_30
  • ISBN: 9781493905836, 9781493906208
  • Peer Reviewed
• [Journal Article] Correlation between asymmetry of spontaneous oscillation of hemodynamic changes in the prefrontal cortex and anxiety levels: a near-infrared spectroscopy study (2014)
  • Author(s): Kaoru Sakatani
  • Journal Title: J Biomed Opt Volume: 19(2) Issue: 2 Pages: 27005-27005
  • DOI: 10.1117/1.jbo.19.2.027005
  • Peer Reviewed
• [Journal Article] Effects of enriched environment on hippocampal neuronal cell death and neurogenesis in rat global ischemia. (2014)
  • Author(s): Kato T, Eriguchi T, Fujiwara N, Murata Y, Yoshino A, Sakatani K, Katayama Y.
  • Journal Title: Adv Exp Med Biol. Volume: 812 Pages: 203-208
  • DOI: 10.1007/978-1-4939-0620-8_27
  • ISBN: 9781493905836, 9781493906208
  • Peer Reviewed
• [Journal Article] Acute stress exposure preceding transient global brain ischemia exacerbates the decrease in cortical remodeling potential in the rat retrosplenial cortex (2014)
  • Author(s): Kaoru Sakatani
  • Journal Title: Neurosci Res Volume: 78 Pages: 65-71
  • DOI: 10.1016/j.neures.2013.10.011
  • Peer Reviewed
• [Presentation] アロマセラピーのストレス緩和作用の神経生理学的メカニズム (2015)
  • Author(s): 酒谷 薫, 谷田正弘
  • Organizer: 第18回日本アロマセラピー学会学術総会
  • Place of Presentation: ワークピア横浜
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] 中国医学における脳と心とからだ (2015)
  • Author(s): 酒谷 薫
  • Organizer: 日本歯科東洋医学会 第３３回学術大会
  • Place of Presentation: 日本大学法学部10号館
  • Year and Date: 2015-10-05
  • Invited
• [Presentation] The role of the task in emotion evocation: a NIRS study (2015)
  • Author(s): A.Compare, A.Brugnera, R.Adorni, and K. Sakatani
  • Organizer: The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
  • Place of Presentation: Wuhan China
  • Year and Date: 2015-07-11
  • Int'l Joint Research
• [Presentation] Correlation between NIRS and EEG Signals during Mental Arithmetic Task Evaluated by Self-Organizing Map (2015)
  • Author(s): K Oyama, K Sakatani
  • Organizer: The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
  • Place of Presentation: Wuhan China
  • Year and Date: 2015-07-11
  • Int'l Joint Research
• [Presentation] Effects of antioxidant supplements (BioPQQTM) on cerebral blood flow and oxygen metabolism in the prefrontal cortex (2015)
  • Author(s): Masahiko Nakano, Yuta Murayama, Lizhen Hu, Kazuto Ikemoto, Tatsuo Uetake, Kaoru Sakatani
  • Organizer: The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
  • Place of Presentation: Wuhan China
  • Year and Date: 2015-07-11
  • Int'l Joint Research
• [Presentation] Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients (2015)
  • Author(s): M. Moriya, C. Aoki, K. Sakatani
  • Organizer: The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
  • Place of Presentation: Wuhan China
  • Year and Date: 2015-07-11
  • Int'l Joint Research
• [Presentation] Relation between prefrontal cortex activity and respiratory rate during mental stress tasks: a near-infrared spectroscopic study (2015)
  • Author(s): Yuta Murayama, Lizhen Hu, Kaoru Sakatani
  • Organizer: The 43th Annual Meeting of the International Society on Oxygen Transport to Tissue
  • Place of Presentation: Wuhan China
  • Year and Date: 2015-07-11
  • Int'l Joint Research
• [Presentation] BCI-based Concentration Exercise system for Training the Mind (2015)
  • Author(s): Kaoru Sakatani, Kazuki Yanagisawa and Hitoshi Tsunashima
  • Organizer: 第9回ICME複合医工学国際会議（CME 2015）
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2015-06-18
  • Int'l Joint Research
• [Presentation] 高齢女性に対する化粧療法が情動と前頭前野に与える効果 (2015)
  • Author(s): 酒谷 薫
  • Organizer: 人工知能学会全国大会（第29回）
  • Place of Presentation: 公立函館未来大学
  • Year and Date: 2015-05-30
  • Invited
• [Presentation] これからの医工連携事業：先端医療から先端介護へ (2015)
  • Author(s): 酒谷 薫
  • Organizer: 第9回横浜ITクラスター交流会
  • Place of Presentation: 横浜情報文化センター
  • Year and Date: 2015-04-16
  • Invited
• [Presentation] NIRSの臨床応用の現状と未来 (2014)
  • Author(s): 酒谷薫
  • Organizer: 日本オプトメカトロニクス協会講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-17
  • Invited
• [Presentation] 脳外科領域におけるイメージングセンサーの現状と未来：CISGをつかった医療用イメージセンサー (2014)
  • Author(s): 酒谷薫
  • Organizer: 第27回マイクロプロセス・ナノテクノロジー国際会議
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-04
  • Invited
• [Presentation] 高齢者の運動療法の認知機能に対する効果ー光学的脳機能計測法による認知機能評価－ (2014)
  • Author(s): 酒谷薫
  • Organizer: 第4回日本中医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-13 – 2014-09-14
  • Invited
• [Presentation] 抑うつ ：鍼灸の作用機転 (2014)
  • Author(s): 酒谷薫
  • Organizer: 第15回日本早期認知症学会学術大会
  • Place of Presentation: 千葉
  • Year and Date: 2014-09-12 – 2014-09-14
  • Invited
• [Presentation] 脳疾患に対するNIRSの臨床応用：過去、現在、未来 (2014)
  • Author(s): 酒谷薫
  • Organizer: 第17回日本光脳機能イメージング学会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-26
  • Invited
• [Presentation] Effects of acupuncture on anxiety levels and prefrontal cortex activity measured by near-infrared spectroscopy (2014)
  • Author(s): Sakatani K, Fujii ., Takemura N, Hirayama T
  • Organizer: ISOTT 2014
  • Place of Presentation: London
  • Year and Date: 2014-06-28 – 2014-07-03
• [Presentation] Effect of antioxidant supplements, Pyrroloquinoline quinone disodium salt (BioPQQTM), on cognitive functions (2014)
  • Author(s): Itoh Y, Hine K, Miura T, Uetake T, Nakano M, Takemura N, Sakatani K
  • Organizer: ISOTT 2014
  • Place of Presentation: London
  • Year and Date: 2014-06-28 – 2014-07-03
• [Presentation] Effects of cosmetic therapy on cognitive function in elderly women evaluated by time-resolved spectroscopy study (2014)
  • Author(s): Machida A, Shirato M, Tanida M, Kanemaru C, Nagai S, Sakatani K
  • Organizer: ISOTT 2014
  • Place of Presentation: London
  • Year and Date: 2014-06-28 – 2014-07-03
• [Presentation] Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State (2014)
  • Author(s): Matsumoto T, Fuchita Y, Ichikawa K, Fukuda Y, Takemura N Sakatani K
  • Organizer: ISOTT 2014
  • Place of Presentation: London
  • Year and Date: 2014-06-28 – 2014-07-03
• [Presentation] Detection of ROSC in patients with cardiac arrest during chest compression using NIRS: A pilot study (2014)
  • Author(s): Yagi T, Nagao K, Kawamorita T, Soga T, Ishii M, Chiba N, Watanabe K, Tani S, Yoshino A, Hirayama A, Sakatani K
  • Organizer: ISOTT 2014
  • Place of Presentation: London
  • Year and Date: 2014-06-28 – 2014-07-03
• [Presentation] Active agingを支援する高齢者の脳と心の健康増進 (2014)
  • Author(s): 酒谷薫
  • Organizer: 第53回日本生体医工学会
  • Place of Presentation: 仙台
  • Year and Date: 2014-06-24 – 2014-06-26
• [Presentation] 光学的生体計測法の臨床医学への応用 (2014)
  • Author(s): 酒谷薫
  • Organizer: 福島県立医科大学産学連携セミナー
  • Place of Presentation: 福島
  • Year and Date: 2014-05-22
  • Invited
• [Presentation] Effects of acupuncture on anxiety levels and prefrontal cortex activity measured by near infrared spectroscopy: a pilot study (2014)
  • Author(s): Sakatani K, Fujii M, Takemura N
  • Organizer: 42nd Meeting of the International Society on Oxygen Transport to Tissue
  • Place of Presentation: London
• [Remarks] 酒谷研究室
  • URL: http://sakatani-lab.org/
• [Patent(Industrial Property Rights)] 遠隔患者支援システム (2016)
  • Inventor(s): 酒谷薫、他2名
  • Industrial Property Rights Holder: 日本大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-061513
  • Filing Date: 2016-03-25
• [Patent(Industrial Property Rights)] 光学的イメージング医療システムおよびカメラ (2014)
  • Inventor(s): 酒谷薫
  • Industrial Property Rights Holder: 日本大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-04-16
  • Acquisition Date: 2015-11-16