| Project/Area Number |
25560374
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Wayo Women's University |
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Principal Investigator |
MINATO Kumiko 和洋女子大学, 生活科学系, 教授 (70211589)
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| Co-Investigator(Kenkyū-buntansha) |
SHIROYA Youko 和洋女子大学, 生活科学系, 准教授 (80183408)
KUROSAKA Yuka 和洋女子大学, 生活科学系, 助手 (30633002)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 慢性膵炎 / 肥満 / 運動習慣 / 食餌制限 / 膵腺房細胞 / 膵B細胞 / 炎症 / 小胞体ストレス / 膵内外分泌機能 / 膵Ｂ細胞 / 電子顕微鏡像 |
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| Outline of Final Research Achievements |
Chronic pancreatitis is an inflammatory disorder, causing a progressive and irreversible dysfunction of exocrine and endocrine pancreas. Recently, leptin receptor-deficient WBN/Kob-Fatty (WKF) rat was developed for a model of chronic pancreatitis and diabetes with obesity. The purpose of this study was to investigate whether chronic exercise with restricted diet improved the exocrine and endocrine pancreas of WKF rats.
Male 12wks WKF rats had symptoms of pancreatitis and diabetes (hyperglycemia, hyperlipidemia, insulin resistance, fatty pancreas, inflammation, morphological abnormality), but WK rats did not. These results indicated that obesity was a major factor to aggravate pancreatitis and diabetes. Chronic exercise with restricted diet beneficially affected the exocrine and endocrine pancreas in WKF rats through the treatment of obesity.
Pancreatic dysfunction of chronic pancreatitis and diabetes may be improved by adequate exercise habit with restricted diet.
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