The influence of lowered intestinal function on mechanism of skeletal muscle atrophy and hypertrophy
| Project/Area Number |
25560377
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Tohoku University (2015)
Tohoku Institute of Technology (2013-2014) |
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Principal Investigator |
Matsuo Kaori 東北大学, 医学(系)研究科(研究院), 助教 (60513570)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | サルコペニア / 腸管機能 / 骨格筋萎縮・肥大 / 腸内細菌 / 骨格筋肥大 / 骨格筋萎縮 / 筋萎縮 / 骨格筋肥大調節因子 |
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| Outline of Final Research Achievements |
Although there is a close relationship between exercise and internal organs, the influence aged or lowered gastrointestinal tract function has on skeletal muscle is not yet clear. Especially, recent study disuse muscle atrophy in the elderly is considered to be muscle atrophy due to aging, so exercises such as muscle training are promoted as a way to prevent sarcopenia. However, attention has been paid to the possibility that the cause of sarcopenia is not just mere skeletal muscle atrophy. Hence, the purpose of this study is (1) to prove the hypothesis that lowered gastrointestinal tract function delays the recovery from muscle atrophy, and (2) to investigate the possibility that the cause of sarcopenia in the elderly is related to lowered digestive function due to aging. These results suggested that after inactivity state by cast fixation (induction of muscle atrophy) that the process of muscle hypertrophy was improved when intake of the probiotics by which maintained gut function.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells.2015
Author(s)
Yamaya M, Shimotai Y, Hatachi Y, Lusamba Kalonji N, Tando Y, Kitajima Y, Matsuo K, Kubo H, Nagatomi R, Hongo S, Homma M, Nishimura H
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Journal Title
Pulm Pharmacol Ther
Volume: 33
Pages: 66-74
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 北海道マラソンにおける調査について2015
Author(s)
杉田正明, 瀧澤一騎, 岡崎和伸, 松生香里, 山口太一, 広川龍太郎, 須永美歌子, 武冨豊, 宗猛, 酒井勝充
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Journal Title
陸上競技研究紀要
Volume: 10
Pages: 150-158
Related Report
Acknowledgement Compliant
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[Presentation] 陸上競技ジュニア選手のスポーツ外傷・障害調査 －第2報－2015
Author(s)
鎌田浩史, 山澤文裕, 鳥居 俊, 櫻庭景植, 向井直樹, 菅原 誠, 前澤克彦, 真鍋知宏, 難波 聡, 田口素子, 松生香里
Organizer
第26回日本臨床スポーツ医学会
Place of Presentation
神戸国際会議場・兵庫
Year and Date
2015-11-08
Related Report
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