Muscular lipid is associated with a risk factor of arterial stiffness.
| Project/Area Number |
25560378
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURIHARA Toshiyuki 立命館大学, スポーツ健康科学部, 助教 (10454076)
HAMAOKA Takafumi 立命館大学, スポーツ健康科学部, 教授 (70266518)
FUJITA Satoshi 立命館大学, スポーツ健康科学部, 教授 (80451863)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脂肪蓄積 / 有酸素性運動 / 動脈硬化 / 筋細胞内脂肪 / 筋細胞外脂肪 |
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| Outline of Final Research Achievements |
This study aimed to clarify the effect of sex, age and cardiorespiratory fitness level on relationship between arterial stiffness and IMCL or EMCL contents (Experiment 1) and the effect of chronic aerobic exercise on IMCL or EMCL contents with arterial stiffness (Experiment 2). Experiment 1: IMCL and EMCL contents in 237 healthy subjects were evaluated by 1H-MRS. Arterial stiffness was estimated using baPWV. In the middle-aged and older female, baPWV negatively correlated with IMCL content, especially, in the low fitness female (r=-0.54, p<0.001). By contrast, significant positive correlation was observed between baPWV and EMCL in the both genders and fitness levels. Experiment 2: By 8-week aerobic exercise intervention in the middle-aged and older adults, the increase in IMCL content was significantly correlated with the reduction of baPWV. Thus, IMCL and EMCL contents may be a risk factor of arterial stiffness, and this association may be differed by gender, age and fitness level.
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Report
(3 results)
Research Products
(58 results)
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[Journal Article] Low-volume, high-intensity, aerobic interval exercise for sedentary adults: VO2max, cardiac mass, and heart rate recovery.2014
Author(s)
Matsuo T, Saotome K, Seino S, Eto M, Shimojo N, Matsushita A, Iemitsu M, Ohshima H, Tanaka K, Mukai C.
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Journal Title
Eur J Appl Physiol
Volume: 114
Issue: 9
Pages: 1963-1972
DOI
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Peer Reviewed
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[Presentation] Ageing-induced reduction in muscle cross-sectional area is associated with serum C1q concentration.2014
Author(s)
Watanabe S, Sato K, Fujita S, Hasegawa N, Fujie S, Sanada K, Kurihara T, Hamaoka T, Iemitsu M.
Organizer
61th American College of Sports Medicine
Place of Presentation
Orlando, Florida, USA.
Year and Date
2014-05-30
Related Report
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[Presentation] Effects of cardiorespiratory fitness level, age, and sex on intramyocellular and extramyocellular lipid contents.2014
Author(s)
Hasegawa N, Kurihara T, Watanabe S, Sato K, Fujita S, Sanada K, Hamaoka T, Iemitsu M.
Organizer
61th American College of Sports Medicine
Place of Presentation
Orlando, Florida, USA.
Year and Date
2014-05-29
Related Report
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[Presentation] Higher cardiorespiratory fitness attenuates arterial stiffening associated with the estrogen receptor-beta polymorphism in the healthy women.
Author(s)
Hayashi K, Iemitsu M, Murakami H, Sanada K, Kawano H, Gando Y, Kawakami R, Tanaka N, Miyachi, M.
Organizer
18th Annual Congress of the European College of Sport Science
Place of Presentation
National Institute of Physical Education of Catalonia, Barcelona Spain
Related Report
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[Presentation] Ghrelin Leu72Met polymorphism affects a relationship between HDL cholesterol and cardiorespiratory fitness level in middle and older adults.
Author(s)
Kono S, Iemitsu M, Murakami H, Fujie S, Sanada K, Kawano H, Gando Y, Kawakami R, Tanaka N, Miyachi, M.
Organizer
18th Annual Congress of the European College of Sport Science
Place of Presentation
National Institute of Physical Education of Catalonia, Barcelona Spain
Related Report
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[Presentation] Cardiorespiratory fitness affects polymorphism in ADRB3 Trp64Arg-caused increase in common carotid intima-media thikness
Author(s)
Fujie S, Iemitsu M, Murakami H, Sanada K, Kawano H, Gando Y, Kawakami R, Tanaka N, Miyachi, M.
Organizer
Experimental Biology 2013
Place of Presentation
Boston Convention & Exhibition Center, Boston, USA
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