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The effects of environmental stresses of high-altitude (i.e., hypoxia and hypothermia) on activation of brown adipose tissue and anti-obesity.

Research Project

Project/Area Number 25560380
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionRitsumeikan University

Principal Investigator

Taguchi Sadayoshi  立命館大学, 総合科学技術研究機構, 教授 (90086819)

Co-Investigator(Kenkyū-buntansha) 松生 香里  東北大学, 医学系研究科, 助教 (60513570)
橋本 健志  立命館大学, スポーツ健康科学部, 准教授 (70511608)
山内 潤一郎  首都大学東京, 人間健康科学研究科, 准教授 (70552321)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords高所 / 低酸素 / 脂質代謝 / 脂肪蓄積 / 肥満 / 代謝特性 / 形態特性 / 運動 / 高所環境 / 低温 / 褐色脂肪 / 白色脂肪 / 褐色脂肪細胞
Outline of Final Research Achievements

This study was conducted to examine the effects of hypoxia and hypothermia on fat metabolism by focusing on UCP1 (Uncoupling protein 1), which is related to brown adipose tissue. We found that hypoxia might not influence the UCP1 expression, while it may inhibit the lipogenesis, thereby reducing the lipid storage in adipocytes.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Spaceflight and Biohistochemical Alterations of Antigravity Soleus Muscle in Spontaneously Hypertensive Rats (SHR) to Dietary Low- and High- Calcium Intake2016

    • Author(s)
      Taguchi S, Ogoh S, Hashimoto T, Yamasaki S, Okamoto H, Yamori Y, Hatton DC and McCarron DA
    • Journal Title

      Journal of Bioanalysis & Biomedicine

      Volume: 8 Issue: 3 Pages: 41-47

    • DOI

      10.4172/1948-593x.1000151

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Specific characterization of regional storage fat in upper and lower limbs of young healthy adults2015

    • Author(s)
      Junichiro Yamauchi, Toshiyuki Kurihara, Maki Yoshikawa, Sadayoshi Taguchi, Takeshi Hashimoto
    • Journal Title

      Springer Plus

      Volume: 4 Issue: 1 Pages: 402-402

    • DOI

      10.1186/s40064-015-1181-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mixed lactate and caffeine compound increases satellite cell activity and anabolic signals for muscle hypertrophy.2015

    • Author(s)
      Oishi Y, Tsukamoto H, Yokokawa T, Hirotsu K, Shimazu M, Uchida K, Tomi H, Higashida K, Iwanaka N, Hashimoto T.
    • Journal Title

      Journal of Applied Physiology

      Volume: 118 Issue: 6 Pages: 742-9

    • DOI

      10.1152/japplphysiol.00054.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 長距離・マラソン選手の腸内環境とコンディションの関連 ー意識調査と外環境の変化に伴う影響についてー2014

    • Author(s)
      松生香里、岡崎和伸、杉田正明
    • Journal Title

      陸上競技研究紀要

      Volume: 10 Pages: 71-86

    • Related Report
      2014 Research-status Report
  • [Journal Article] Modest hypoxia significantly reduces triglyceride content and lipid droplet size in 3T3-L1 adipocytes.2013

    • Author(s)
      Hashimoto T, Yokokawa T, Endo Y, Iwanaka N, Higashida K, and Taguchi S.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 440 Issue: 1 Pages: 43-49

    • DOI

      10.1016/j.bbrc.2013.09.034

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The effect of hypoxia on skeletal muscle characteristic2017

    • Author(s)
      Hashimoto T, Osaki T
    • Organizer
      The 94th Annual meeting of the Physiological Society of Japan
    • Related Report
      2016 Annual Research Report
  • [Presentation] Lactate and Caffeine treatment can increase fat oxidation on resting metabolic rate in rats2016

    • Author(s)
      Kim J, Yoo C-S, Hashimoto T, Tomi H, Kawasaki M, Lim K
    • Organizer
      The 67th Annual meeting of Korean Society of Food Science and Nutrition
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Caffeine and Lactate mixture treatment on gene expressions related to energy metabolism in rat skeletal muscle2016

    • Author(s)
      Yoo C-S, Kim J, Hashimoto T, Tomi H, Kawasaki M, Teramoto N, Lim K
    • Organizer
      The 67th Annual meeting of Korean Society of Food Science and Nutrition
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歩動作時の上肢と下肢: ヒトが4足で歩くと?2015

    • Author(s)
      山内潤一郎, 小池英晃, 清水麻由子, 湯浅健人, 小山桂史, 橋本健志, 田口貞善
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館、和歌山県和歌山市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 高所4000m酸素環境下における活動筋の発汗特性2015

    • Author(s)
      小池英晃, 森田憲輝, 小山桂史, 橋本健志, 田口貞善, 山内潤一郎
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館、和歌山県和歌山市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 高所4000m酸素環境曝露における低強度運動時のエネルギー利用と血中乳酸濃度2015

    • Author(s)
      小池英晃, 森田憲輝, 小山桂史, 橋本健志, 田口貞善, 山内潤一郎
    • Organizer
      第164回日本体力医学会関東地方会
    • Place of Presentation
      桐蔭横浜大学、神奈川県横浜市
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Ambient Particular Matter (pm) Exposure Deteriorates Pulmonary Function in Early Childhood in Shanghai, China2015

    • Author(s)
      Taguchi S, Otsuka M, Suzuki K, Yamasaki S, Kitagawa K, Yin X-J, Ji L, Zhou Y-R, Liu X, and Hashimoto T
    • Organizer
      62th American College of Sport Medicine
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The relationship between subcutaneous fat and intramuscular lipid in human limb.2014

    • Author(s)
      Yoshikawa M, Kurihara T, Taguchi S, Yamauchi J, and Hashimoto T.
    • Organizer
      19th European College of Sport Science
    • Place of Presentation
      Amsterdam(Netherlands)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Exercise-induced response in sweating and body temperature during cycling exercise with moderate intensity.2014

    • Author(s)
      Koike H, Kobayashi K and Yamauchi J.
    • Organizer
      European College of Sport Science (Abstracts)
    • Place of Presentation
      Amsterdam(Netherlands)
    • Year and Date
      2014-07-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Body composition of human limbs by using BIA and MRI.

    • Author(s)
      Maki Yoshikawa, Toshiyuki Kurihara, Sadayoshi Taguchi, Junichiro Yamauchi, Takeshi Hashimoto.
    • Organizer
      18th European College of Sport Science
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト上腕部における皮下脂肪と筋内脂肪の関係

    • Author(s)
      吉川 万紀、栗原 俊之、田口 貞善、山内 潤一郎、橋本 健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      日本教育会館(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] Aging, not inactvity, alters lactate metabolic properties to facilitate lactate oxidation in fast-type skeletal muscle.

    • Author(s)
      Sadayoshi Taguchi, Shinya Masuda, Tatsuro Egawa, Tatsuya Hayashi.
    • Organizer
      Med.Sci.Sports Exerc.
    • Place of Presentation
      Indianapolis, U.S.A.
    • Related Report
      2013 Research-status Report
  • [Presentation] Relation between waist circumference and body mass index in Chinese children and adlescents.

    • Author(s)
      Xiao Jian Yin, Chen Ye Ji, Liu Ji, Qiang Guo, Shi Chang Li, Sadayoshi Taguchi, Toyoho Tanaka.
    • Organizer
      Med.Sci.Sports Exerc.
    • Place of Presentation
      Indianapolis, U.S.A.
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-12-27  

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