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Mechanisms underlying spacing effect of memory

Research Project

Project/Area Number 25560382
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

ENDO Shogo  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60192514)

Co-Investigator(Renkei-kenkyūsha) YANAI Shuichi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60469070)
ARASAKI Tomoko  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 技術員 (90645855)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords記憶 / 学習 / リハビリテーション / 小脳 / 一酸化窒素 / 活性酸素種 / 眼球運動 / 8-ニトロ-cGMP / グアニル化 / 休憩 / 分散学習
Outline of Final Research Achievements

Motor learning is a basis for the physical rehabilitation. The spaced training efficiently forms long-term memory compared to the massed training. The existence of spacing effect in memory mechanisms indicates the importance of the inter-trial-interval (the rest). The mechanisms underlying long-term during the inter-trial-interval, however, is largely unknown. In this research, first, we established the long-term adaptation of optokinetic response as a simple model of motor memory. Then, we demonstrated the 30 and 60 min inter -trial-interval works efficiently for the formation of the long-term adaptation. In addition, we analyzed reactive oxygen species-nitric oxide pathway as a potential system underlying spacing effect and identified components of the pathway in the cerebellum, the center of motor learning.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (12 results) (of which Invited: 1 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Cilostazol improves hippocampus-dependent long-term memory in mice2014

    • Author(s)
      Shuichi Yanai, Yuki Semba, Hideki Ito, & Shogo Endo
    • Journal Title

      Psychopharmacology

      Volume: - Issue: 13 Pages: 2681-2693

    • DOI

      10.1007/s00213-014-3442-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction.2014

    • Author(s)
      Ulm S, Liu W, Zi M, Tsui H, Chowdhury SK, Endo S, Satoh Y, Prehar S, Wang R, Cartwright EJ, Wang X.
    • Journal Title

      J Mol Cell Cardiol

      Volume: 72C Pages: 104-116

    • DOI

      10.1016/j.yjmcc.2014.03.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.2014

    • Author(s)
      P. Srimontri, S. Endo, T. Sakamoto, Y. Nakayama, A. Kurosaka, S. Itohara, Y. Hirabayashi, K Kato.
    • Journal Title

      J Neurochem.

      Volume: 131 Issue: 5 Pages: 675-687

    • DOI

      10.1111/jnc.12838

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The effect of diazepam on mouse PTSD-like behaviors induced by the 2011 Tohoku earthquake.2014

    • Author(s)
      S. Yanai, Y. Semba, and S. Endo.
    • Journal Title

      Behav Sci Res

      Volume: 53 Pages: 27-36

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer’s disease mouse model2014

    • Author(s)
      Setogawa S, Yamaura H, Arasaki T, Endo S, Yanagihara D
    • Journal Title

      Scientific Reports

      Volume: 4:7200 Issue: 1 Pages: 1-10

    • DOI

      10.1038/srep07220

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013

    • Author(s)
      Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
    • Journal Title

      BMC Genomics.

      Volume: 14(1): Issue: 1 Pages: 248-248

    • DOI

      10.1186/1471-2164-14-248

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction2013

    • Author(s)
      Kujiraoka T, Satoh Y, Ayaori M, Shiraishi Y, Arai-Nakaya Y, Hakuno D, Yada H, Kuwada N, Endo S, Isoda K, Adachi T.
    • Journal Title

      J Am Heart Assoc

      Volume: 2 Issue: 4

    • DOI

      10.1161/jaha.113.000361

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deep cerebellar nuclei play an important role in two-tone discrimination on delay eyeblink conditioning in C57BL/6 mice.2013

    • Author(s)
      Sakamoto, T., and Endo, S.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 3 Pages: e59880-e59880

    • DOI

      10.1371/journal.pone.0059880

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 神経可塑性・記憶におけるMEK1/2-ERK1/2の役割、2013

    • Author(s)
      遠藤昌吾
    • Journal Title

      Clinical Neuroscience

      Volume: 31 Pages: 688-691

    • Related Report
      2013 Research-status Report
  • [Journal Article] MAPKカスケード2013

    • Author(s)
      佐藤泰司、遠藤昌吾
    • Journal Title

      Clinical Neuroscience

      Volume: 31 Pages: 649-649

    • Related Report
      2013 Research-status Report
  • [Presentation] Maintenance of memory functions by chronic administration of cilostazol, a phosphodiesterase 3 inhibitor, in aged mice models.2014

    • Author(s)
      Shuichi Yanai, Kai Kojima, Tomoko Arasaki & Shogo Endo
    • Organizer
      Annual meeting of Society for Neuroscience
    • Place of Presentation
      Washignton D.C., USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cilostazol,a phosphodiesterase 3 inhibitor, improves memories in senescence accelerated mice.2014

    • Author(s)
      S. Yanai, T. Arasaki, and S. Endo.
    • Organizer
      Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Phosphodiesterase 3 inhibitor cilostazol improves conditioned fear in SAM-P8 mice.2014

    • Author(s)
      S. Yanai, K Kojima, T. Arasaki, and S. Endo.
    • Organizer
      Annual meeting of Japan Society for Biomedical Gerontology
    • Place of Presentation
      Obu, Aichi, Japan
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 記憶改善薬のスクリーニングとSAM2014

    • Author(s)
      遠藤昌吾
    • Organizer
      SAM研究協議会研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Allodynia is reduced in mice deficient for ERK2.2014

    • Author(s)
      Y. Satoh, Y. Otsubo, G. Pagès, J. Pouysségur, S. Endo, T. Kazama.
    • Organizer
      2014
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Research-status Report
  • [Presentation] Abnormal neuropathic pain in mice deficient for ERK2 in the central nervous system.2013

    • Author(s)
      Otsubo Y., Satoh Y., Kodama M., Araki Y., Satomoto M., Sakamoto E., Pages G., Pouyssegur J., Endo S., Kazama T.
    • Organizer
      8th “Pain in Europe” Congress
    • Place of Presentation
      Florence, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] Deletion of hepatic ERK2 decreased the SERCA2 expressions, which can account for vascular oxidative stress and endothelial dysfunction in metabolic stress.2013

    • Author(s)
      T. Adachi, T. Nanba, Y. Satoh, M. Ayaori, Y. Shiraishi, Y.Arai-Nakaya, D. Hakuno, H. Yada, K. Isoda, S. Endo, T. Kujiraoka
    • Organizer
      11th International symposium on mechanisms on vasodilation,
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2013 Research-status Report
  • [Presentation] Annormal pain in mice deficient for ERK2 in the central nervous system.2013

    • Author(s)
      Y. Otsubo-iwama, Y. Satoh, S.Endo, G. Pages, J. Pouysegur, T. Yamamoto, Y. Takahashi, T. Kazama
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Deficits in working memory related to obstacle avoidance during locomotion in Alzheimer’s disease mutant mice.2013

    • Author(s)
      S. Setogawa, H. Yamaura, S. Endo, D. Yanagihara.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Deep cerebellar nuclei play an important role in two-tone discrimination on delay eyeblink conditioning in C57BL/6 mice.2013

    • Author(s)
      T. Sakamoto, S. Endo.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Distribution of 8-nitro-cGMP and S-guanylated proteins in cerebellum.2013

    • Author(s)
      S. Endo, M. Nakamura,T. Arasaki,T. Akaike
    • Organizer
      Japan Neuroscience Society
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Cilostazol, a PDE3 inhibitor, improves learning and memory in mice.2013

    • Author(s)
      S. Yanai, Y. Semba, S. Endo.
    • Organizer
      Japan Neuroscience Society
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Book] Brain Aging and Therapeutic Interventions (Thakur and Rattan Ed.)2013

    • Author(s)
      Shogo Endo
    • Total Pages
      296
    • Publisher
      Springer
    • Related Report
      2013 Research-status Report
  • [Remarks] 記憶神経科学、東京都老人研

    • URL

      http://www2.tmig.or.jp/Mn_B/Japanese/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 記憶神経科学、東京都老人研

    • URL

      http://www2.tmig.or.jp/Mn_B/Japanese/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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