Mechanisms underlying spacing effect of memory
Project/Area Number |
25560382
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied health science
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
ENDO Shogo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60192514)
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Co-Investigator(Renkei-kenkyūsha) |
YANAI Shuichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60469070)
ARASAKI Tomoko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 技術員 (90645855)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 記憶 / 学習 / リハビリテーション / 小脳 / 一酸化窒素 / 活性酸素種 / 眼球運動 / 8-ニトロ-cGMP / グアニル化 / 休憩 / 分散学習 |
Outline of Final Research Achievements |
Motor learning is a basis for the physical rehabilitation. The spaced training efficiently forms long-term memory compared to the massed training. The existence of spacing effect in memory mechanisms indicates the importance of the inter-trial-interval (the rest). The mechanisms underlying long-term during the inter-trial-interval, however, is largely unknown. In this research, first, we established the long-term adaptation of optokinetic response as a simple model of motor memory. Then, we demonstrated the 30 and 60 min inter -trial-interval works efficiently for the formation of the long-term adaptation. In addition, we analyzed reactive oxygen species-nitric oxide pathway as a potential system underlying spacing effect and identified components of the pathway in the cerebellum, the center of motor learning.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction.2014
Author(s)
Ulm S, Liu W, Zi M, Tsui H, Chowdhury SK, Endo S, Satoh Y, Prehar S, Wang R, Cartwright EJ, Wang X.
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Journal Title
J Mol Cell Cardiol
Volume: 72C
Pages: 104-116
DOI
Related Report
Peer Reviewed
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[Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013
Author(s)
Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
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Journal Title
BMC Genomics.
Volume: 14(1):
Issue: 1
Pages: 248-248
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction2013
Author(s)
Kujiraoka T, Satoh Y, Ayaori M, Shiraishi Y, Arai-Nakaya Y, Hakuno D, Yada H, Kuwada N, Endo S, Isoda K, Adachi T.
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Journal Title
J Am Heart Assoc
Volume: 2
Issue: 4
DOI
Related Report
Peer Reviewed
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[Presentation] Abnormal neuropathic pain in mice deficient for ERK2 in the central nervous system.2013
Author(s)
Otsubo Y., Satoh Y., Kodama M., Araki Y., Satomoto M., Sakamoto E., Pages G., Pouyssegur J., Endo S., Kazama T.
Organizer
8th “Pain in Europe” Congress
Place of Presentation
Florence, Italy
Related Report
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[Presentation] Deletion of hepatic ERK2 decreased the SERCA2 expressions, which can account for vascular oxidative stress and endothelial dysfunction in metabolic stress.2013
Author(s)
T. Adachi, T. Nanba, Y. Satoh, M. Ayaori, Y. Shiraishi, Y.Arai-Nakaya, D. Hakuno, H. Yada, K. Isoda, S. Endo, T. Kujiraoka
Organizer
11th International symposium on mechanisms on vasodilation,
Place of Presentation
Zurich, Switzerland
Related Report
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